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All Journal Journal of Dentomaxillofacial Science
Gostry A. Dohude
Department of Oral and Maxillofacial Surgery, Faculty of Denstistry Universitas Sumatera Utara, Medan, Indonesia
Dentistry

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Local anaesthetic inhibition of lidocaine on the growth of streptococcus mutans in vitro Gostry A. Dohude; Mulyani Rahmah
Journal of Dentomaxillofacial Science Vol. 7 No. 2 (2022): (Available online: 1 August 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v7i2.1382

Abstract

Objective: This study aims to determine the effectiveness of lidocaine of local anaesthetic agent in inhibiting the growth of streptococcus mutans bacteria. Material and Methods: This type of research is a laboratory experimental with a post test only control group design. Microorganism used was streptococcus mutans and cultured at the Microbiology Laboratory of the Pharmacy, Universitas Sumatera Utara. The local anaesthetic tested was a solution of lidocaine diluted with NaCl 0.9% to 0.5%, 1%, and 2%. The antibacterial activity test was carried out using diffusion method by dripping 25 µl of lidocaine (0.5%, 1%, 2%), positive control (amoxicillin), and negative control (NaCl 0.9%) on disc paper, then placed on nutrient agar, and incubated. After 24 hours, the inhibition zone formed around the disc paper was observed. Results: Lidocaine showed antibacterial activity with the inhibition zone of 0.5%, 1%, 2% concentration was 6.98 mm, 7.66 mm, 8.36 mm. Then the data was analyzed using the One-way ANOVA test. From these results, there was a significant difference in the mean of the inhibitin zone (p < 0.05) between 0.5%, 1%, and 2% lidocaine, positive control, and negative control. Conclusion: Lidocaine has antibacterial activity against Streptococcus mutans bacteria with an effective concentration of 2%.
Co-Authors Mulyani Rahmah