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All Journal International Journal of Electrical and Computer Engineering Media Penelitian dan Pengembangan Kesehatan Medical Journal of Indonesia
Rahyussalim Rahyussalim, Rahyussalim
Departemen Medik Orthopaedi Dan Traumatologi RSCM-FKUI Jakarta, Indonesia
Computer Science & IT Decision Sciences, Operations Research & Management Electrical & Electronics Engineering Medicine & Pharmacology Public Health

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Preservasi Kolum Posterior dengan Menggunakan Teknik Debridement Invasi Minimal pada Penderita Spondilitis Tuberkulosis Torakal Umur 2 Tahun Rahyussalim, Rahyussalim; Kurniawati, Tri; Setiawaty, Vivi
Media Penelitian dan Pengembangan Kesehatan Vol 25, No 2 Jun (2015)
Publisher : Badan Penelitian dan Pengembangan Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (829.249 KB)

Abstract

Spondilitis tuberkulosis merupakan penyakit infeksi tulang belakang yang disebabkan olehMycobacterium tuberculosis. Penyakit ini dapat ditemukan di semua lapisan masyarakat dan di berbagaiusia. Spondilitis tuberkulosis pada anak dapat mengakibatkan deformitas yang merupakan masalahserius. Hal ini disebabkan karena anak-anak memiliki sistem imun yang rentan infeksi pada tulang yangsedang bertumbuh. Destruksi korpus vertebra yang masif dan kolum posterior yang masih intak menjadialasan untuk mempertahankan struktur dan menjaga kestabilan tulang belakang pada anak. Kondisiini perlu dipertimbangkan dalam menentukan modalitas penatalaksanaan. Pada teknik konvensionalpendekatan anterior menjadi pilihan dalam upaya mencapai lesi tulang belakang, karenanya dilakukantindakan debridement, evakuasi abses dan pemasangan strut graft untuk menyangga tulang belakang.Dalam perkembangannya teknik ini menimbulkan masalah lain pada anak yaitu kolapsnya korpusvertebra. Dengan pendekatan posterior teknik konvensional melakukan laminektomi untuk mencapailesi korpus vertebra yang berada di anterior, cara ini pun berpotensi mengakibatkan semakin tidakstabilnya tulang belakang. Pendekatan ini dapat menyebabkan kelainan postural. Paper ini melaporkanhasil evaluasi terhadap penderita spondilitis tuberkulosis anak usia 2 tahun yang telah dilakukan teknikpreservasi kolum posterior dengan debridement invasi minimal. Hasil evaluasi hingga 1 tahun setelahpenatalaksanaan memperlihatkan bahwa teknik yang digunakan memberikan stabilitas tulang belakangyang baik selain masa pemulihan yang lebih singkat dan perdarahan yang lebih sedikit.
X-ray radiation effect of C-arm on adipose tissue-mesenchymal stem cell viability and population doubling time Rahyussalim, Ahmad J.; Pawitan, Jeanne A.; Kusnadi, Alam R.; Kurniawati, Tri
Medical Journal of Indonesia Vol 25, No 1 (2016): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (851.947 KB) | DOI: 10.13181/mji.v25i1.1335

Abstract

Background: Adipose tissue derived mesenchymal stem cells (AT-MSCs) are relatively easy in isolation procedure compared to bone marrow-derived. Minimally invasive MSC injections need C-arm as guidance that potentially influence the cell viability and doubling time. This study aimsed to determine the effect of C-arm X-ray exposure on AT-MSC viability and population doubling time (PDT).Methods: This experimental study used cryopreserved adipose tissue derived MSCs stored in Stem Cell Medical Technology Integrated Service Unit Cipto Mangunkusumo Hospital. Cells were thawed, propagated, and exposed to varying doses of C-arm X-ray radiation. Stem cell viability was measured, and then the cells were cultured to assess their PDT. Generalized linear models test was used to compare cell viability between post-thaw, post-propagation, post-radiation, post-culture post-radiation, and control and between radiation dose groups. Kruskal-Wallis test assessed PDT between various radiation doses in post-radiation groups. Wilcoxon test was used to assess PDT between pre-radiation and post-radiation groups.Results: Mean confluence period of adipose MSCs post- irradiation was 4.33 days. There was no statistically significant difference in MSC viability after X-ray exposure between pre- and post-irradiation groups (p=0.831). There was no correlation between post-irradiation viability and radiation dose (p=0.138, r=0.503). There were no significant differences in PDT between pre- and post-culture post-irradiation groups and between various radiation doses in post-irradiation groups (p=0.792).  Conclusion: MSC viability and PDT were not influenced by radiation exposure up to 32.34 mgray.
The potential of carbonate apatite as an alternative bone substitute material Rahyussalim, Ahmad Jabir; Supriadi, Sugeng; Marsetio, Aldo Fransiskus; Pribadi, Pancar Muhammad; Suharno, Bambang
Medical Journal of Indonesia Vol 28, No 1 (2019): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (339.221 KB) | DOI: 10.13181/mji.v28i1.2681

Abstract

Bone reconstructive surgery has become a common procedure, and bone transplantation has become the second most frequently performed tissue transplantation procedure worldwide. Therefore, the need for bone substitute materials has increased. Artificial bone substitutes exhibit osteoconductive properties and feature several advantages, including abundant resources, low cost, and low donor site morbidity. Carbonate apatite (CO3Ap) is a calcium phosphate ceramic that can be used as a synthetic bone graft. The carbonate content of this ceramic is similar to that of bone apatite. In this review, we show that carbonate apatite can be degraded given its chemical reactivity in a weakly acidic environment and through osteoclast resorption. Moreover, it is osteoconductive and promotes bone tissue formation without fibrotic tissue formation. Additionally, microstructural analysis revealed that new bone tissue is formed within the bone graft itself.
Computed tomography image analysis for Indonesian total hip arthroplasty designs Talitha Asmaria; Dita Ayu Mayasari; Alfensa Dinda Gestara Febrananda; Nadiya Nurul; Ahmad Jabir Rahyussalim; Ika Kartika
International Journal of Electrical and Computer Engineering (IJECE) Vol 12, No 6: December 2022
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/ijece.v12i6.pp6123-6131

Abstract

Total hip arthroplasty purposes to replace a hip joint damaged by an artificial hip joint. However, the developed products that already exist in the market lead to the mismatch between the hip implant equipment and the patient’s bone morphometric. Besides causing complications, the mismatch also continues to the dislocation effects, fracture, osteolysis, and thigh pain. This paper aims to design a customized hip implant based on real patient data, particularly for Indonesian patient, limited to the acetabular components and stem parts. The computed images were analyzed to estimate the patient proximal femur morphometric; those are the femoral head diameter, neck-shaft angle, mediolateral width, anteroposterior width, neck length and neck width. The experiment has succeeded in designing the acetabular shell with the thickness of 3 mm, the acetabular liner with the thickness of 6 mm, the femoral head between 22.4 to 24.8 mm, the short stem in both the right for 110.656 mm and left femur bone for 111.49 mm; that fit the patient's femur bone. Overall, the proposed steps in designing the customized hip implant in this work, based on image analysis on medical imaging data, can be a standard to be applied for other patient-needs hip arthroplasty implants.
Co-Authors Alam R. Kusnadi, Alam R. Alfensa Dinda Gestara Febrananda Bambang Suharno Dita Ayu Mayasari, Dita Ayu Ika Kartika Jeanne A. Pawitan Marsetio, Aldo Fransiskus Nadiya Nurul Pribadi, Pancar Muhammad Sugeng Supriadi, Sugeng Talitha Asmaria Tri Kurniawati, Tri Vivi Setiawaty