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All Journal SRIWIJAYA JOURNAL OF MEDICINE Indonesian Journal of Cancer
PATIYUS AGUSTIANSYAH
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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VEGF-C Serum Level as Predictor Lymph Node Metastasis in Advanced Stage Cervical Cancer PATIYUS AGUSTIANSYAH
Indonesian Journal of Cancer Vol 8, No 3 (2014): Jul - Sep 2014
Publisher : National Cancer Center - Dharmais Cancer Hospital

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (822.343 KB) | DOI: 10.33371/ijoc.v8i3.357

Abstract

The aim of this study to identify correlation between VEGF-C and lymph node metastasis in advanced stage cervicalcancer in Dr. Hasan Sadikin General Hospital Bandung from April to August 2013.Cross sectional study from 30 patients diagnosed with advanced stage Cervical Cancer (IIB IVA). We performedtransperitoneal lymphadenectomy pelvic and para-aortic and measuring VEGF-C serum with ELISA priorchemoradiation.Results : 17/30 patients (56.7%) metastasis to pelvic lymph nodes and 4/30 pastients (13.3%) metastases to para-aorticlymph nodes. VEGF-C > 5333 pg/mL has a metastasis risk to pelvic lymph node 21.6 times with 94% sensitivity; 84.6%specificity; 88.9% positive predictive value; and 84.6% negative predictive value. Meanwhile VEGF-C > 8915.5 pg/mL hasa metastasis risk to para-aortic lymph node 15 times with 75% sensitivity, 100% specificity, 100% positive predictivevalue and 96.3% negative predictive value in advanced stage cervical cancer.Conclusion: a significant correlation between VEGF-C serum level with lymph node metastasis (pelvic and para-aortic)(p < 0.05)
Perioperative and Postoperative Management in Gynecologic Oncologic Patients: A Narrative Review Nurkulis; Patiyus Agustiansyah
Sriwijaya Journal of Medicine Vol. 8 No. 3 (2025): Vol 8, No 3, 2025 (Issue In Progress)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v8i3.353

Abstract

Gynecologic cancers, particularly cervical, ovarian, and endometrial cancers, remain among the leading causes of mortality in women. Surgery, the cornerstone of treatment, is often associated with significant perioperative risks, necessitating careful evaluation and management to optimize outcomes. This review analyses perioperative and postoperative factors influencing morbidity and mortality in gynecologic oncology and evaluates the role of Enhanced Recovery After Surgery (ERAS) protocols in improving outcomes. A literature search by Google Scholar, PubMed, and ScienceDirect identified eight relevant evidence-based studies published within the last decade. Findings demonstrate that ERAS accelerates recovery, reduces complications, and lowers healthcare costs. Key components—such as patient education, multimodal analgesia, bowel function optimization, and early mobilizations significantly enhance postoperative recovery. Patients with comorbid endocrine, cardiovascular, renal, and electrolyte disorders require intensive monitoring and tailored management to prevent complications. Overall, the application of ERAS in gynecologic oncology improves recovery, reduces morbidity, and enhances quality of life, particularly when combined with vigilant monitoring in high-risk patients.
Co-Authors Nurkulis