Garuda - Garba Rujukan Digital

Ermi Girsang

Public Health Department, Faculty Of Medicine Universitas Prima Indonesia Medan, Indonesia

Author-ID : 5334997

Nursing Public Health

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Articles

Hepatoprotective Effectiveness Test of Salam Leaf Extract in Anthracyclin-Induced Rats Hariyento Halim; Ermi Girsang; Ali Napiah Nasution
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 1 (2022): February 2022
Publisher : CV. Inara

Cancer is the most often diagnosed disease in the world and the top cause of death. Doxorubicin is a widely used systemic therapy, although its efficacy is limited by dose-related toxicity, including haematological suppression, organotoxicity, and hepatotoxicity. Bay leaf is a commonly utilised plant in the community for treating and preventing many diseases because it includes secondary metabolites that are antioxidants such as phenolics, alkaloids, saponins, steroids, triterpenoids, and tannins. The purpose of this work is to characterise EEDS, identify its secondary metabolite content, and test its nephroprotective effect in doxorubicin-induced rats using SGPT and SGOT levels and liver histology. This is a laboratory experimental investigation using rats and comprises of treatment groups receiving 0.5% of CMC-Na, Nature E, or EEDS at doses of 100 mg/kgBW, 300 mg/kgBW, or 500 mg/kgBW, respectively, followed by doxorubicin. The results indicated that EEDS had 21.64 % water soluble material, 1.79 % total ash, 9.98 % water, 45.38 % ethanol soluble extract, and 0.39 % acid insoluble ash. EEDS included alkaloids, flavonoids, tannins, glycosides, saponins, and steroids/triterpenoids, as determined by phytochemical screening. EEDS doses of 100 mg/kgBW, 300 mg/kgBW, and 500 mg/kgBW can significantly lower SGPT by 34%; 52,46%; 59,31% and SGOT levels by 27,05%; 43,96%; 50,07% and can improve the liver histopathology of doxorubicin-induced rats by reducing pyknotic degeneration, inflammatory cell infiltration, bleeding, steatosis and sinusoidal dilatation with an effective dose of 500 mg/kgBW with a significant difference with the doxorubicin group followed by 0.5% CMC Na. The key to bay leaf ethanol extract has hepatoprotective activity.

Coriander Seed Extract ( Coriandum Sativum L ) as an antioxidant Irza Haicha Pratama; Ermi Girsang; Tan Suyono
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 1 (2022): February 2022
Publisher : CV. Inara

Diabetes mellitus (DM) is a disease characterized by hyperglycemia, lipoprotein abnormalities, increased basal metabolic rate, enzyme deficiency, and high oxidative stress. This research is an experimental study that aims to explore coriander seed extract (Coriandrum sativum L) using Post-Test Only Control Group Design. This study to was conducted to see the antioxidant potential (DPPH, ABTS, LC-MS/MS) of coriander seed extract (Coriandrum sativum L). Based on the test results, coriander seed extract contains very high phytochemicals, one of which is alkaloid compounds, and in vitro test results found DPPH antioxidant with an average IC50 value of 14.33 g/mL and at the lowest concentration (6.25 g/mL). g/mL), CSE also showed the highest antioxidant activity against ABTS trapping with an average IC50 value of 74.07 g/mL and the results of LC-MS/MS obtained samples of coriander extract containing 0.00009% chlorogenic acid and quercetin compounds. of 0.00012%.

Analysis of Service Factors that Influence the Bed Occupancy Rate in the Inpatient Room of Royal Prima Medan General Hospital Wiwin Dwi Handayani; Tan Suyono; Sri Lestari Nasution; Ermi Girsang
International Journal of Health and Pharmaceutical (IJHP) Vol. 2 No. 1 (2022): February 2022
Publisher : CV. Inara

The government has a responsibility to ensure that every citizen gets health services. Minimum Service Standards Indicators aim to be a benchmark of achievement in hospital performance. The indicator that is often used is the Bed Occupancy Rate (BOR). The state of the inpatient installation is an internal determinant of increasing satisfaction from consumers (patients). The aim of the research is to help local governments to improve the level of public health. As well as helping Royal Prima General Hospital Medan provide the best health services, and high quality standards. This research is a quantitative analytical-observational study with a cross sectional approach. Performed at the private public hospital Royal Prima Medan. Primary and secondary data collection was carried out in March-May 2021. Data analysis used a quantitative analysis approach; Data editing, data coding, univariate analysis, bivariate analysis.This analysis was carried out by using the Analysis of Variance (ANOVA) test on the program IBM SPSS. The research subjects came from inpatient room respondents from grades 1, 2, and 3. Based on the results of the study, the attitude of medical personnel was significant (P=0.04) towards services. Medical and medical services were not significant (P=0.13) on health services. Public facilities and infrastructure are significant (P=0.03) on health services. Distance and location of settlements are not significant (P=0.18) to health services. In conclusion, the attitude of medical personnel and public facilities affects the patient's interest. Meanwhile, distance, residential location, and medical services did not affect the patient's interest. Suggestions from this research are to improve the performance of medical personnel and hospital workers, by conducting training and training gradual coaching, to support more conducive health services at Royal Prima General Hospital Medan

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