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All Journal Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Jurnal Jamu Indonesia
Septiana Laksmi Ramayani
Prodi DIII Farmasi, Politeknik Katolik Mangunwijaya
Agriculture, Biological Sciences & Forestry Medicine & Pharmacology Other

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PENGARUH METODE EKSTRAKSI TERHADAP KADAR TOTAL FENOLIK, KADAR TOTAL FLAVONOID DAN AKTIVITAS ANTIOKSIDAN EKSTRAK DAUN MENGKUDU (Morinda citrifolia L.) Septiana Laksmi Ramayani; Eka Amalia Permatasari; Indah Novitasari; Maryana Maryana
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol 18, No 01 (2021): Jurnal Ilmu Farmasi & Farmasi Klinik
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (97.368 KB) | DOI: 10.31942/jiffk.v18i01.4898

Abstract

ABSTRACT Excessive Reactive Oxygen Species (ROS) can cause hypertension. Prevention of the risk of hypertension is consume an antioxidant. Noni (Morinda citrifolia L). is a plant that empirically proven to lower blood pressure and has antioxidant activity. Antihypertensive activity of noni leaves is influenced by phenolic and flavonoid compounds. The extraction method affects the levels of compound in extracts. The aims of study is determine the effect of the extraction method on the total phenolic level, total flavonoid level and antioxidant activity of noni leaf extract. The extraction methods are maceration, Microwave Assisted Extraction and Soxhlet. The results showed that the different extraction methods affected the total phenol level, total flavonoid level and antioxidant activity of the noni leaf extract. The Soxlet method provides the highest total phenolic level, total flavonoid level and antioxidant activity than other extraction methods. Keywords: Noni leaf extract, extraction method, total phenolic level, total flavonoid level and antioxidant activity
The effect of Material to Solvent Ratio to The Flavonoid Content and Free Radical Scavenging Activity of Extract of Morinda Citrifolia L Leaves Septiana Laksmi Ramayani; Fitria Rohmawati; Yasmine Savira Rahmadani
Jurnal Jamu Indonesia Vol. 7 No. 2 (2022): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v7i2.245

Abstract

The flavonoid compound in Noni leaves (Morinda citrifolia) are efficacious as free radical scavengers. This research aimed to know the influence of the ratio of materials and a solvent (M:S=1:10; M:S=1:15; M:S=1:20) on the flavonoid content and free radical scavenging activity of extract of noni leaves. Extraction was carried out using the Microwave Assisted Extraction method and the free radical scavenging activity were determined by 1,1-diphenyl-2-picrylhydrazyl (DPPH). The results showed that the material-solvent ratio had a significant effect on the yield, total flavonoid content, and free radical scavenging activity. The material to solvent ratio 1: 20 resulted in the highest yield, total flavonoid content, and free radical scavenging activity compared to other solvent-solvent ratios.
Co-Authors Eka Amalia Permatasari Fitria Rohmawati Indah Novitasari Maryana Maryana Yasmine Savira Rahmadani