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All Journal Acta Chimica Asiana Makara Journal of Science
Orie, Kingsley John
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Chemistry

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Synthesis and Complexation of Monotosylated 4-Aminopyridine with Nickel (II) and Iron (II) Ions Orie, Kingsley John; Duru, Remy Ukachukwu; Ngochindo, Raphael I-oro
Makara Journal of Science Vol. 25, No. 3
Publisher : UI Scholars Hub

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Abstract

Tosylated 4-aminopyridine and other sulfonylated compounds of amines comprise a substantial class of pharmaceutical drugs used as antibiotics in the field of medicine. This research aimed at the synthesis of tosylated 4-aminopyridine and the complexation of the tosyated 4-aminopyridine with Ni(II) and Fe(II) ions. The sulfonamide was prepared by the action of tosyl chloride on 4-aminopyridine in an aqueous alkaline medium. The complexes were synthesized by the reaction of Ni(NO3)2.6H2O /Fe(NO3)2.6H2O with sulfonamide derivative. These compounds were characterized through Ultraviolet Visible spectroscopy (UV–Vis), Fourier Transform Infer-Red (FTIR) spectroscopy, Proton Nuclear Magnetic Resonance (1HNMR), Carbon-13 Nuclear Magnetic Resonance (13CNMR) and Electron Spray Ionisation-Mass Spectrometer (ESI-MS) and micro-analysis. The IR spectral data suggested that the sulfonamide derivative acts as a neutral ligand towards Ni (II) and Fe (II). In their complexes, the coordination frequency bands of 1665.55 and 1674.21 cm−1 were assigned to Ni−N and Fe−N bonds, and 1687.70 cm−1 was assigned to free tosylated 4-aminopyridine. This decrease in the frequency band of free imine to coordinated imine complexes indicates that electron transfer occurred from the ligand to the d-orbitals of the metals. The complexation of4-Methyl-N-(pyridin-4-yl)benzene sulfonamide can increase the biological and catalytic potential of the ligand in the pharmaceutical and chemical industries.
Synthesis and characterization of silver nanoparticles using Ocimum gratissimum root extract and their biological activities against some clinical pathogens Nzerema, Chioma Mercy; Nna, Prince Joe; Orie, Kingsley John
Acta Chimica Asiana Vol. 8 No. 2 (2025)
Publisher : The Indonesian Chemical Society, Chapter Nusa Tenggara and The University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/aca.v8i2.267

Abstract

This study investigates the green synthesis of silver nanoparticles (AgNPs) using Ocimum gratissimum root extract, along with their characterization and antibacterial efficacy. Proximal analysis revealed low moisture (8.02 ± 0.11%), crude protein (3.31 ± 0.28%), crude fat (2.01 ± 0.59%), moderate fibre (9.18 ± 0.40%), and ash (5.11 ± 0.91%), indicating a carbohydrate-rich composition. AgNPs were synthesized using the root extract as reducing and stabilizing agent; UV–Vis spectroscopy confirmed their formation with a surface plasmon resonance peak at 425 nm, consistent with spherical nanoparticles (30–100 nm). FTIR identified phenolic and polysaccharide functional groups (O–H, C=O, C–O), while XRD indicated a face-centered cubic (FCC) structure with good crystallinity. SEM micrographs showed mostly spherical particles with minimal aggregation. Antimicrobial activity at 10–20 mg/mL was tested against Proteus mirabilis, Pseudomonas aeruginosa, Bacillus cereus, Aspergillus fumigatus, Candida albicans, and Saccharomyces cerevisiae. The root extract alone showed no activity at 10 mg/mL but exhibited dose-dependent inhibition at higher concentrations (ZOIs: 10.40–15.16 mm). AgNPs displayed stronger broad-spectrum efficacy (ZOIs: 7.12–18.9 mm), often surpassing gentamicin. These findings highlight the potential of O. gratissimum root-derived AgNPs as eco-friendly antibacterial agents against multidrug-resistant organisms.
Co-Authors Duru, Remy Ukachukwu Ngochindo, Raphael I-oro Nna, Prince Joe Nzerema, Chioma Mercy