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Pengaruh Pemberian Terapi Oksigen Hiperbarik 2,4 ATA Terhadap Kadar C-Reactive Protein (CRP) Darah Mencit Model Rheumatoid Arthritis Tamara, Thalia; Andisari, Hendrata Erry; Mudjiono, Totot
Oceana Biomedicina Journal Vol 2, No 2 (2019): Oceana Biomedicina Journal
Publisher : Universitas Hang Tuah

Latar Belakang: Artritis Rheumatoid/ Rheumatoid Arthritis (RA) adalah suatu penyakit autoimun dengan prevalensi yang terus meningkat dari tahun ke tahun. Angka kematian RA terus meningkat dalam 1 dekade terakhir akibat belum ditemukannya pencegahan dan terapi yang efektif. Terapi oksigen hiperbarik bisa menjadi terapi adjuvant untuk penderita Rheumathoid Arhtritis.Tujuan: Penelitian ini menggunakan Terapi Oksigen Hiperbarik untuk mengurangi reaksi inflamasi pada penderita Rheumatoid Arthritis.Metode: Sampel yang digunakan adalah Mice BALB/C jantan sebanyak 16 ekor yang dibagi menjadi 2 kelompok, yaitu 1) kelompok mencit yang diinduksi menjadi model Rheumatoid Arthritis, 2) kelompok hewan coba yang diinduksi menjadi model Rheumatoid Arthritis dan diberikan terapi HBO 2,4 ATA 3x30 menit selama 10 hari berturut-turut. Pada hari ke-59 dilakukan pemeriksaan C-Reactive Protein menggunakan metode ELISA.Hasil: Hasil rerata kadar C-Reactive Protein antara 2 kelompok yaitu, kelompok mencit model RA yang tidak diterapi HBO memiliki rerata kadar CRP 0.204 Pg/ml, sedangkan kelompok mencit model RA yang diterapi HBO memiliki rerata kadar CRP 0.113 Pg/ml.Kesimpulan: Terdapat pengaruh terapi oksigen hiperbarik terhadap kadar C-Reactive Protein darah mencit model rheumatoid arthritis.Kata kunci: Rheumatoid Arthritis, Terapi Oksigen Hiperbarik, C-Reactive Protein

Pengaruh Pemberian Terapi Oksigen Hiperbarik 2,4 ATA terhadap Kadar C-Reactive Protein (CRP) Darah Mencit Model Rheumatoid Arthritis Thalia Tamara; Hendrata Erry Andisari; Totot Mudjiono
Denta Journal Kedokteran Gigi Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

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Background: Rheumatoid Arthritis (RA) is an autoimmune disease with an increasingprevalence from year to year. RA mortality continues to increase in the last 1 decade due tothe absence of effective prevention and therapy. Hyperbaric oxygen therapy can be anadjuvant therapy for Rheumathoid Arthritis.Objective: This study uses Hyperbaric Oxygen Therapy to reduce the inflammatory reactionin patients with Rheumatoid Arthritis.Method: Samples used are 16 male balb/c mice, divided into 2 groups, 1) group of inducedexperimental animals as models of Rheumatoid Arthritis 2) group of induced experimentalanimals as models of Rheumatoid Arthritis and given 3x30 minutes of 2.4 ATA hyperbaricoxygen therapy for 10 consecutive days. On 59th day, ELISA screening test is performed forC-ReactiveProtein measurement.Result: The average results of C-Reactive Protein levels between 2 groups, are, the group ofmice with rheumatoid arthritis model that was not treated with HBO therapy had an averageCRP level of 0.204 Pg / ml, while the group of mice with rheumatoid arthritis model which istreated with HBO therapy has a mean CRP level of 0.113 Pg / ml.Conclusion: There is an effect of hyperbaric oxygen therapy to C-Reactive Protein level inmice with rheumatoid arthritis model.

Hubungan Pemberian Terapi Oksigen Hiperbarik Terhadap Aktifitas Osteoblastik Dan Osteoklastik Pada Tikus Model Fraktur CALVIN JUSO HANDONO; TOTOT MUDJIONO; ANNISA ULLYA RASYIDA
HANG TUAH MEDICAL JOURNAL Vol 19 No 2 (2022): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v19i2.267

Background : Fracture is a condition where the bone is cut off due to significant pressure which can be in the form of bending, twisting, or pulling due to trauma, work accidents, traffic accidents, as well as degeneration and pathological processes. Fractures can result in loss of productivity and individual disability. One of the adjuvant therapies to accelerate the bone healing process in patients with fractures is hyperbaric oxygen (HBO) therapy. Objective: The purpose of this study was to determine the effect of Hyperbaric Oxygen therapy on the amount of osteoblasts and osteoclasts formed in ratsmodeled with diaphyseal femur fractures. Methods: This research is an experimental study using a post test only control group design. The object of this study is a rat fracture model with TOHB therapy as the independent variable and a fracture model without HBO therapy as a control variable. Results: The results of this study showed positive results on the effect of HBO therapy on the formation of osteoblastic and osteoclastic cells. Conclusion: There was a significant difference in the number of osteoblast and osteoclast in fracture model mice treated with HBO compared to those not treated with HBO. Keywords: HBO therapy, Fracture, Callus, Osteoblast, Osteoclast, Wistar Rat

Pengaruh Pemberian Terapi Oksigen Hiperbarik 2,4 ATA terhadap Kadar C-Reactive Protein (CRP) Darah Mencit Model Rheumatoid Arthritis Thalia Tamara; Hendrata Erry Andisari; Totot Mudjiono
Oceana Biomedicina Journal Vol 2 No 2 (2019): Oceana Biomedicina Journal Volume 2 Issue (No) 2 July - December 2019
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/obj.v2i2.33

Background: Rheumatoid Arthritis (RA) is an autoimmune disease with an increasingprevalence from year to year. RA mortality continues to increase in the last 1 decade due tothe absence of effective prevention and therapy. Hyperbaric oxygen therapy can be anadjuvant therapy for Rheumathoid Arthritis.Objective: This study uses Hyperbaric Oxygen Therapy to reduce the inflammatory reactionin patients with Rheumatoid Arthritis.Method: Samples used are 16 male balb/c mice, divided into 2 groups, 1) group of inducedexperimental animals as models of Rheumatoid Arthritis 2) group of induced experimentalanimals as models of Rheumatoid Arthritis and given 3x30 minutes of 2.4 ATA hyperbaricoxygen therapy for 10 consecutive days. On 59th day, ELISA screening test is performed forC-ReactiveProtein measurement.Result: The average results of C-Reactive Protein levels between 2 groups, are, the group ofmice with rheumatoid arthritis model that was not treated with HBO therapy had an averageCRP level of 0.204 Pg / ml, while the group of mice with rheumatoid arthritis model which istreated with HBO therapy has a mean CRP level of 0.113 Pg / ml.Conclusion: There is an effect of hyperbaric oxygen therapy to C-Reactive Protein level inmice with rheumatoid arthritis model.

Implant Failure and Acetabular Protrusion Post Austin Moore Prosthesis: A Case Report Bagus Meurah Suropati; Bagus Wibowo Soetojo; Rakha Rahmatullah Ibrahim; Totot Mudjiono
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.22978

Implant failure and acetabular protrusion are significant complications following Austin Moore prosthesis insertion, particularly in elderly patients with hip fractures. Total hip arthroplasty (THA) offers superior outcomes compared to hemiarthroplasty (HA) but comes with its own set of challenges. Understanding the risk factors and implications of these complications is crucial for choosing effective management. In this article, we report a 76-year-old woman who presented with severe left hip pain post-fall, eight years after HA with an Austin Moore prosthesis due to a trochanter fracture. The patient was able to walk with a walker before the fall. Physical examination revealed tenderness and limited range of motion. Radiographic imaging confirmed acetabular protrusion and AMP neck fracture. Conversion to THA using a hybrid system was performed successfully, with the patient exhibiting no post-operative complications. This case report showed that implant failure and acetabular protrusion pose complex challenges, exacerbated by patient demographics, implant design, and bone quality. THA emerges as a preferred option due to its superior outcomes, although conversion from HA is associated with increased risks. Early diagnosis and intervention, as well as a multidisciplinary approach and careful consideration of patient-specific factors, are crucial for optimizing patient outcomes and quality of life.

Implant Failure and Acetabular Protrusion Post Austin Moore Prosthesis: A Case Report Suropati, Bagus Meurah; Soetojo, Bagus Wibowo; Ibrahim, Rakha Rahmatullah; Mudjiono, Totot
Qanun Medika - Jurnal Kedokteran FK UMSurabaya Vol 9 No 01 (2025): Qanun Medika Vol 09 No 01 January 2025
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/jqm.v9i01.22978

Implant failure and acetabular protrusion are significant complications following Austin Moore prosthesis insertion, particularly in elderly patients with hip fractures. Total hip arthroplasty (THA) offers superior outcomes compared to hemiarthroplasty (HA) but comes with its own set of challenges. Understanding the risk factors and implications of these complications is crucial for choosing effective management. In this article, we report a 76-year-old woman who presented with severe left hip pain post-fall, eight years after HA with an Austin Moore prosthesis due to a trochanter fracture. The patient was able to walk with a walker before the fall. Physical examination revealed tenderness and limited range of motion. Radiographic imaging confirmed acetabular protrusion and AMP neck fracture. Conversion to THA using a hybrid system was performed successfully, with the patient exhibiting no post-operative complications. This case report showed that implant failure and acetabular protrusion pose complex challenges, exacerbated by patient demographics, implant design, and bone quality. THA emerges as a preferred option due to its superior outcomes, although conversion from HA is associated with increased risks. Early diagnosis and intervention, as well as a multidisciplinary approach and careful consideration of patient-specific factors, are crucial for optimizing patient outcomes and quality of life.

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