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Iryani Iryani
Jurusan Kimia, Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas Negeri Padang, Jl. Prof. Dr.Hamka Padang
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology

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Uji Bioaktivitas Antidiabetes Ekstrak Etil Asetat dari Kulit Buah Jengkol (Pitecellobium jiringa (Jack) Prain ex King) pada Mencit Putih (Mus musculus L) Jantan Elfi Yenti; Iryani Iryani; Erda Sofjeni
Jurnal Periodic Jurusan Kimia UNP Vol 2, No 2 (2013)
Publisher : Departemen Kimia FMIPA UNP

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (262.609 KB) | DOI: 10.24036/p.v2i2.3028

Abstract

Diabetes mellitus is a metabolic disease characterized by blood glucose level that exceed normal limits (hyperglycemia). Treatment of this disease can be done with medicall and herbs. Among the herbal treatment is to use plants such as pandanus pandan wangi, sambiloto, rind mahkota dewa and rind jengkol (Pithecellobium jiringa (Jack) Prain ex King) which has antidiabetic effect. We have done a research of  antidiabetic bioactivity of ethyl acetate extract from the rind jengkol on white male mice. The goal of research to determine the effect of ethyl acetate extract of the rind jengkol in decreasing blood glucose levels of the male  white mice (Mus musculus L.), and to determine the dose and timing of the ethyl acetate extract in  lowing blood glucose level to the olwest point. Research was conducted with on experimental study with a completely randomized design (CRD) with two factor variation is doses of ethyl acetate extract (125, 250, and 500 mg / kg mice) and treatment time (60,90,120, and 150 minutes). This study uses a glucose tolerance test. Blood glucose level of mice were measured using a Glucose Multicheck NESCO ®. Data were statistically analyzed using analysis of variants (ANOVA), followed by Duncan's multiple reng test. The result showed that the ethyl acetate extract of the rind jengkol on white male mice gives the effect on decreasing the mean blood glucose level, which Fcalculated> Ftable. Fcalculated is 10.93, while the F table is 4.77 (0.01 α). Dose of ethyl acetate extract rind jengkol that gives the highest blood glucose level drop is 500 mg / kg with a treatment time of ethyl acetate extract of rind jengkol 150 minutes.
Uji Bioaktivitas Ekstrak Etil Asetat Kulit Manggis (Garcinia mangostana L.) sebagai Antidiabetes pada Mencit Putih (Mus musculus L.) Jantan Sri Hastuti Siregar; Iryani Iryani; Erda Sofjeni
Jurnal Periodic Jurusan Kimia UNP Vol 2, No 2 (2013)
Publisher : Departemen Kimia FMIPA UNP

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.686 KB) | DOI: 10.24036/p.v2i2.3038

Abstract

Diabetes mellitus represents a disease marked with blood glucose level that exceeding situation of normal boundary ( hiperglikemia). Treatment of this disease can be done with medicall and alternativety. Medication of alternativety by using materials of flora owning effect of hipoglikemia like ethyl acetate extract of mangosteen rind (Garcinia mangostana L.). This study about activity determination of antidiabetes ethyl acetate extract of mangosteen rind. This study to know influence giving of ethyl acetate extract mangosteen rind to degradation of blood glucose level of the white male mice (Mus musculus L.), and to determine effective treatment time and dose to blood glucose level of the white male mice. Glucose blood levels determined with glucose tolerance method use appliance of NESCO Multicheck Glucose®. Dose variation ethyl acetate extract of mangosteen rind the used 125, 250 and 500 mg/kg BW with time variation of 60, 90, 120, and 150 minutes. The decreasing blood glucose of analysed statistically by using analysis of variant (ANOVA) and followed by Duncan’s multiple reng test. The decreasing result of examination of KGD (blood glucose level) with dose 125, 250 and 500 mg/kg BW give effect of blood glucose levels  meaning, where calculated F value > critical F value. Price of calculated F value is 6,25, while critical F value is 4,77 (0,01 α). Dose of ethyl acetate extract mangosteen rind that gives the highest blood glucose level 20,4 % is 500 mg/kg BW with time a time of ethyl acetate extracts of mangosteen rind 150 minutes.
Co-Authors Elfi Yenti Erda Sofjeni Sri Hastuti Siregar