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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya SRIWIJAYA JOURNAL OF MEDICINE
Desi Oktariana
Departement of Clinical Pathology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Quality of Life Based on Autologous Serum Skin Test Result in Chronic Spontaneous Urticaria Patients Mahvira Chow Liana Herman Adil; Nopriyanti; Desi Oktariana; Yuli Kurniawati; Gita Dwi Prasasty
Sriwijaya Journal of Medicine Vol. 4 No. 1 (2021): Vol 4, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v4i1.94

Abstract

Several studies regarding the quality of life of chronic spontaneous urticaria patients based on Autologous Serum Skin Test (ASST) results have shown a variety of results. This study aims to determine the correlation between the quality of life and ASST results in chronic spontaneous urticaria patients at Dermatology and Venereology (DV) Outpatient Clinic of Dr. Mohammad Hoesin Hospital Palembang. This analytic observational study with a cross-sectional design used secondary data in the form of medical records. 76 samples met the inclusion criteria from 110 samples of chronic spontaneous urticaria patients at DV outpatient clinic. The distribution of chronic spontaneous urticaria patients was highest in the 17-25 year age group (23.7%) and the female group (64.5%). The majority of chronic spontaneous urticaria patients had negative ASST results (52.6%). The effect of chronic spontaneous urticaria on the decline in quality of life was mostly moderate (35.5%). The bivariate analysis between DLQI score and ASST results with a value of p = 0.307 or p> 0.05 showed no significant correlation between the quality of life and ASST results.
Prevalence and Sensitivity Pattern of Gram-negative Bacilli Multidrug-Resistant (MDR) In Mohammad Hoesin Hospital Palembang Vena Sabputri Sutrisno; Mastiar Endang Frida Siahaan; Desi Oktariana; Phey Liana; Lusia Hayati
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 9 No. 1 (2022): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universi
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v9i1.188

Abstract

Antibiotic resistance is one of the most serious global health crisis and threats in human life today. Multidrug-resistant is a condition obtained when bacteria are resistant to at least one of the agents of 3 or more antimicrobial categories. Cases of multi-resistant gram-negative bacilli infection continue to increase so that the use of standard antibiotics is non-susceptible leading to increased morbidity and mortality. Therefore, this study aims to find out which antibiotics are still sensitive as empirical therapy. This retrospective descriptive research uses secondary data in the form of the status of patients infected with A. baumannii, P. aeruginosa, E. coli and K. pneumoniae at the Central Laboratory Installation of Mohammad Hoesin Hospital Palembang during the period January 2020 – June 2020. The samples in this study were all medical records of inpatients who met the inclusion criteria. Data is processed and analyzed univariately using Microsoft Excel 2020 and IBM SPSS Statistics Version 26 to determine the frequency distribution of each variable studied. Prevalence of MDR gram-negative bacilli at Mohammad Hoesin Hospital Palembang was MDR A. baumannii (66.5%), MDR P. aeruginosa (34.6%), ESBL-E. coli (61.3%), CRE-E. coli (2.7%), ESBL-K. pneumoniae (51.7%) and CRE-K. pneumoniae (20.1%). Based on the inpatient room, prevalence of MDR gram-negative bacilli is found in intensive care compared to non-intensive care rooms. Based on specimen type, MDR gram-negative bacilli isolates are often found in all types of specimens namely sputum, blood, pus, swab, others. Based on sensitivity patterns, Enterobacteriaceae producing ESBL isolates are sensitive to carbapenem, amikacin, tigecyclin and nitrofurantoin, while in CRE isolates are sensitive to tigecycline. MDR A. baumannii is sensitive to tigecycline and amikacin, but MDR P. aeruginosa is only sensitive to amikacin. The prevalence of MDR gram-negative bacilli is the highest in the intensive inpatient rooms and varies in specimen type. Antibiotics that are sensitive to the entire MDR gram negative bacilli is tigecycline, except MDR P. aeruginosa is sensitive to amikacin.
Identification of -2849 IL-10 Gene Promoter Polymorphism in Leprosy Patient Desi Oktariana; Arina P. Jatmiko; Mutiara Budi Azhar
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 9 No. 3 (2022): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universi
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v9i3.294

Abstract

Leprosy is a chronic granulomatous disease. Leprosy is caused by M. leprae. However, not all exposure to M. leprae causes the disease. The condition of the host immune system determines the pathogenesis of leprosy. Interleukin-10 work as a pro- and anti-inflammatory cytokine. Polymorphism in the IL-10 gene promoter affects the amount of IL-10 secretion. The amount of IL-10 secretion determines the body’s response to M. leprae. The purpose of this study was to determine the distribution of -2849 IL-10 gene promoter polymorphism in leprosy patient at RSUP dr. Mohammad Hoesin Palembang. This research is an observational descriptive study with cross sectional design. Polymorphism identification was performed using PCR-RFLP. A total of 50 samples were identified. Most of the leprosy patients at RSUP dr. Mohammad Hoesin for the period January – February were < 50 years old (73.47%), male (66%), MB leprosy (92%), and came from Malay-South Sumatra ethnicity (53.06%). The genotype frequency distribution was GG 93.88%, AG 6.12%, and AA 0%. The frequency of allele G was 96.94% and allele A 3.06%. The majority of leprosy patients at RSUP dr. Mohammad Hoesin had wild-type genotypes.
Co-Authors Arina P. Jatmiko Gita Dwi Prasasty Lusia Hayati Mahvira Chow Liana Herman Adil Mastiar Endang Frida Siahaan Mutiara Budi Azhar Nopriyanti Phey Liana Vena Sabputri Sutrisno Yuli Kurniawati