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Ian Effendi
Department of Internal Medicine, Faculty of Medicine, Universitas Sriwijaya, Indonesia
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Factors Influence Carotid Intima Thickening Media Thickness in Chronic Kidney Disease Patients Ade Yonata; Zulkhair Ali; Taufik Indrajaya; Ian Effendi; Novadian Suhaimi; Suprapti; Erial Bahar
Biomedical Journal of Indonesia Vol. 6 No. 1 (2020): Vol 6, No 1, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.10539

Abstract

Chronic kidney disease (CKD) is associated with high mortality rates related to cardiovascular complications. Atherosclerosis, arteriosclerosis and vascular calcification conditions are often found in CKD patients. Carotid intima media thickness (cIMT) thickening is one of the parameters of vascular disorders. a cross sectional study was conducted on patients with chronic kidney disease in the Mohammad Hoesin hospital Palembang. Blood samples were examined in the hospital laboratory. CIMT thickening was examined using echocardiography. 55 patients with stage 3-5 of chronic kidney disease were examined. The median cIMT was 0.8 (0.6-1.45) mm. Spearman's correlation analysis showed a significant correlation between triglyceride levels and thickening of cIMT (r = 0.303, p = 0.025). A significant correlation was also shown between phosphate levels and cIMT thickening (r = 0.290, p = 0.032). There were significant correlations of triglyceride levels and phosphate levels on the thickening of cIMT in chronic kidney disease patients at Mohammad Hoesin Hospital Palembang.
Correlation of Serum Sclerostin Levels with Carotid Intima Media Thickness in Chronic Kidney Disease Patients with Hemodialysis Adhi Permana; Ian Effendi; Taufik Indrajaya; Erial Bahar
Biomedical Journal of Indonesia Vol. 6 No. 1 (2020): Vol 6, No 1, 2020
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v6i1.10185

Abstract

Chronic kidney disease is associated with high mortality rates mainly to cardiovascular disease related with mineral and bone disorders. Sclerostin is an inhibitor of Wnt signaling which has the effect of increasing vascular calcification in patients with chronic kidney disease. There are several studies that show different results. Carotid intima media thickness ultrasound examination is a tool to identify atherosclerosis which is part of vascular calcification. The purpose of this study is to look at the correlation of sclerostin with carotid intima media thickness (CIMT) in patients with chronic kidney disease undergoing maintenance hemodialysis. In this cross-sectional study, the sclerostin concentration was measured by an enzymed linked immunosorbent assay. CIMT measurement by ultrasound mode B examination. There were 40 patients in this study. The mean sclerostin level was 256.68 ± 127.76 pg / ml. Sclerostin levels are considered high above 162 pg / ml, there are 30 people. CIMT thickening was present in 11 patients. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing maintenance hemodialysis (r-0.32 p0,847). In multivariate linear regression, hemodialysis vintage is an independent factor that is significantly significant with CIMT. There was no significant correlation of serum sclerostin with CIMT in patients with chronic kidney disease undergoing hemodialysis.
Co-Authors Ade Yonata Adhi Permana Erial Bahar Novadian Suhaimi Suprapti Taufik Indrajaya Zulkhair Ali