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All Journal ISM (Intisari Sains Medis) : Jurnal Kedokteran
Santi Syafril
Departemen Ilmu penyakit Dalam, Fakultas Kedokteran Universitas Sumatera Utara/RSUP Haji Adam Malik Medan, Indonesia
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Hubungan kadar serum gamma-glutamyl transferase dengan profil lipid pada Diabetes Melitus-Tipe 2 (DM-2) terkontrol dan tidak terkontrol di Rumah Sakit Umum Pusat Haji, Adam Malik Medan, Indonesia Furiyani Furiyani; Santi Syafril; Burhanuddin Nst
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (240.652 KB) | DOI: 10.15562/ism.v10i3.426

Abstract

Background: Diabetes mellitus is a group of metabolic diseases with characteristics of hyperglycemia that occur due to impaired insulin secretion, insulin work, or both whereas also impaired lipid peroxidation caused by oxidative stress. Gamma-glutamyl transferase (GGT) is an enzyme on the surface of the cell membrane that is responsible for the catabolism of glutathione which acts as a marker of oxidative stress. This study aims to determine the relationship of serum GGT levels with lipid profiles in controlled and uncontrolled type 2 DM.Method: A cross-sectional study was conducted at H. Adam Malik General Hospital Medan from September - November 2018 among 60 patients with type 2 DM grouped according to HbA1c <7% controlled and HbA1C > 7% uncontrolled. GGT levels and lipid profiles examined using enzymatic calorimetry and HbA1c with Immunoturbidimetry method. The relationship of serum GGT levels with lipid profiles in controlled DM-2 was tested using the Pearson correlation test whereas controlled DM-2 correlation test using the Spearman's correlation test using SPSS version 21 for Windows.Results: Most of respondents were males with HbA1C levels <7% (53.3%) and HbA1C ≥ 7% (60.0%). There was no difference in the mean age and serum GGT levels between uncontrolled DM-2 or controlled DM-2 group (P = 0.260 and P = 0.520, respectively). There was no association between serum GGT levels and lipid profiles in the controlled type 2 DM group and uncontrolled type 2 DM. (r=P> 0.05).Conclusion: There is no significant relationship between serum GGT levels and lipid profiles in controlled and uncontrolled type 2 DM groups.
Hubungan kadar TNF-α dengan HOMA-IR pada pasien diabetes mellitus tipe-2 di Rumah Sakit Umum Pusat Haji Adam Malik, Medan, Indonesia Poltak Poltak; Santi Syafril; Ratna Akbari Ganie
Intisari Sains Medis Vol. 10 No. 3 (2019): (Available online: 1 December 2019)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.393 KB) | DOI: 10.15562/ism.v10i3.467

Abstract

Background: The homeostatic assessment (HOMA) of the first cell-β (B) and insulin (IR) function is used to determine insulin sensitivity and cell-β function of insulin plasma concentrations and fasting glucose. High extracellular glucose levels will trigger an increase in ROS production (which in turn will increase the formation of Reactive Oxygen Species) expression of TNF α (Tumor Necrosis Factor-α) and exacerbate oxidative stress. The study aimed to determine the relationship between TNF α and HOMA-IR in type 2 DM.Method: A cross sectional study was conducted at the H. Adam Malik General Hospital Medan from December-February 2018 in 43 patients with type 2 DM. Fasting insulin levels were examined using Celuminescence Microparticle Immunoassay and fasting glucose levels with Enzymatic and TNF α methods with the Elisa method. The relationship of the characteristics of TNF α levels with HOMA-IR in type 2 DM using the Kolmogorov Smirnov test used the Spearman's rank correlation test with SPSS version 20 for windows.Results: The total sample was 43 samples of patients with type 2 diabetes mellitus. Most of the respondents were male (62.8%) and had a median age of 57 (39-87) years. In this study, the TNF-alpha levels were 87.28 (18.43-846.05) pg/ml. While the HOMA-IR level was 3.36 (0.41-25.82). There was no significant correlation between serum TNF α levels and HOMA-IR in type 2 DM patients (P> 0.05).Conclusion: There is no significant relationship between TNF α levels and HOMA-IR in type 2 DM patients.
Co-Authors Burhanuddin Nst Furiyani Furiyani Poltak Poltak Ratna Akbari Ganie