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All Journal Trends in Infection and Global Health
Arli Aditya Parikesit
Department of Bioinformatics School of Life Sciences Indonesia International Institute for Life Sciences Jl. Pulomas Barat Kav.88 Jakarta 13210 Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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3D molecular structure analysis of NS2B/NS3 proteases derived from dengue virus and Zika virus Arli Aditya Parikesit; Stefanus Bernard
Trends in Infection and Global Health Vol 2, No 1 (2022): June 2022
Publisher : School of Medicine, Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24815/tigh.v2i1.25485

Abstract

Both dengue and Zika viruses have infected millions of people worldwide, urging the development of efficacious drugs and vaccines to fight the infection. Unfortunately, current research is yet to elucidate the structural proteomics comparison of the NS2B/NS3 from both viruses. Therefore, the main objective of this study was to comparatively study the structural proteins between dengue and Zika viruses by leveraging standard homology modelling tools. Our data provide 3D molecular structure overviews of NS2B/NS3 derived from the foregoing viruses. Sequence alignment indicated that the viruses share a 56% similarity rate of protein structures. However, in terms of function, both have NS2B that is pivotal for the activation of NS3 proteases.
Co-Authors Stefanus Bernard