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All Journal ZAHRA: JOURNAL OF HEALTH AND MEDICAL RESEARCH Journal of Innovative and Creativity
Lathvi Masyithah
Universitas Gunadarma
Dentistry Education Health Professions Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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PENAMBATAN MOLEKUL DAN PREDIKSI UJI TOKSISITAS PADA SENYAWA TURUNAN INHIBITOR GATA-2 SEBAGAI PENINGKAT TRANSKRIPSI ERITROPOIESIS Dona Suzana; Ashfar Kurnia; Dina Melia Oktavilantika; Lathvi Masyithah
ZAHRA: JOURNAL OF HEALTH AND MEDICAL RESEARCH Vol. 2 No. 3 (2022): JULI
Publisher : CV. ADIBA ADISHA AMIRA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (557.652 KB)

Abstract

Anemia is a condition in which the number of red blood cells or the amount of hemoglobin, a protein responsible for transporting oxygen throughout the body, is below normal. The condition of chronic kidney disease causes a decrease in hemoglobin levels in the body so that it affects the proliferation of red blood cells. The search for compounds to stimulate the process of red blood cell proliferation without involving erythropoietin was carried out. Pyrrotiogatain compounds are believed to increase the proliferation of red blood cells, but are reported to have serious toxicity. Then modification of the molecule is carried out to find the effectiveness which has lower toxicity. Several pyritiogartain derivatives have been produced which are effective with molecular tethering and determination of the productive toxicity.
Gambaran Lama Rawat Inap Pasien Pneumonia Balita Berdasarkan Jenis Terapi Antibiotik di Rumah Sakit X Jakarta Lathvi Masyithah; Erischa Putri Diana; Dona Suzana
Journal of Innovative and Creativity Vol. 5 No. 2 (2025)
Publisher : Fakultas Ilmu Pendidikan Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/joecy.v5i2.2588

Abstract

Pneumonia is one of the leading causes of morbidity and mortality in infants in Indonesia. Antibiotic therapy is a key component of its treatment. However, the choice between single antibiotic therapy and combination therapy remains a subject of debate, particularly in relation to efficiency and length of hospital stay. This study aims to compare the length of hospital stay in infants with pneumonia who received single antibiotic therapy and combination antibiotic therapy at Hospital X. The study employs a quantitative observational design with a retrospective approach. Data were collected from medical records of pediatric pneumonia patients during a specific period at Hospital X, with 44 patients receiving single antibiotic therapy and 6 patients receiving combination therapy. Data analysis was performed using the non-parametric Mann–Whitney test to compare hospitalization duration between the two therapy groups. The results of the Mann–Whitney test showed no significant difference in the length of hospital stay between patients receiving monotherapy and combination therapy (p = 0.214; p ≥ 0.05). This indicates that monotherapy provides clinically comparable outcomes to combination therapy in terms of length of hospital stay. Single antibiotic therapy was found to be comparable in effectiveness to combination therapy in terms of length of hospital stay in infants with pneumonia. These results support the application of rational antibiotic therapy principles and provide a basis for the efficient use of antibiotics.
Co-Authors Ashfar Kurnia Dina Melia Oktavilantika Dona Suzana Erischa Putri Diana