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All Journal The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Fransiscus Ari
Department of Internal Medicine, Faculty of Medicine, University of Indonesia Dr. Cipto Mangunkusumo General National Hospital, Jakarta
Medicine & Pharmacology

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Current Prevention and Management of Non Steroid Anti Inflammatory Drugs Associated Gastroenteropathy Fransiscus Ari; Dadang Makmun
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 15, No 3 (2014): VOLUME 15, NUMBER 3, December 2014
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (186.855 KB) | DOI: 10.24871/1532014161-169

Abstract

Non-steroid anti-inflammatory drugs (NSAIDs) are the most frequently used drugs to treat inflammation and are used almost in the whole world. However, NSAID is one of the important causes of gastroenteropathy development. NSAIDs enteropathy is frequently undetected because most of them are asymptomatic and required sophisticated examinations to diagnose. Not only non-selective cyclo-oxygenases (COX) inhibitor that can cause NSAID gastropathy, but selective COX-2 inhibitors may also cause gastrointestinal complications. NSAID gastroenteropathy require further evaluation and it may differ between patients.Currently, there is no effective treatment available to treat gastrointestinal damage associated with NSAIDs administration. Identification of protective factors in gastrointestinal complication due to NSAIDs use is still a serious challenge. In this review, we will discuss the effect of NSAID administration towards gastrointestinal system, also the prevention and management strategies.Keywords: non-steroid anti-inflammatory drugs, gastroenteropathy, COX inhibitor, prevention, treatment
Co-Authors Dadang Makmun