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All Journal IJOEP : International Journal of Ecophysiology The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
Taufik Sungkar
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Agriculture, Biological Sciences & Forestry Medicine & Pharmacology

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The Comparison of Serum Malondialdehyde Level Between H. pylori Positive and H. pylori Negative Gastritis Patients Laura Dairi; Gontar Alamsyah Siregar; Taufik Sungkar
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy Vol 19, No 1 (2018): VOLUME 19, NUMBER 1, April 2018
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (365.671 KB) | DOI: 10.24871/19120183-6

Abstract

Background: Helicobacter pylori is the most common cause of chronic gastritis in the world, meanwhile gastritis caused by non-steroidal anti-inflammatory drugs (NSAIDs) is the most encountered type of gastritis.Increased free radicals caused by Helicobacter pylori can cause damage in gastric mucous. Tissue damage due to free radicals can be examined by measuring malondialdehyde compound. There are many studies thatproves the increased malondialdehyde in gastritis, but those studies commonly done in animal experimentation and malondialdehyde examination in gastric mucous.Method: This is a cross-sectional study of 40 dyspepsia patients who came to endoscopic unit of Adam Malik General Hospital Medan and networking hospitals by using Rome III criteria. Further examination with gastroscopy and biopsy was done to determine gastritis. H. pylori examination was done by using Campylobacterlike organism test (CLO) test. Serum malondiasldehyde level was examined with high performance liquid chromatography (HPLC) method.Results: From total of 40 patients,24 (60%) were men and 16 (40%) were women with an average age of 47years, the majority of the ethnic was Bataknese (57.5%). From 20 patients with H.pylori (+), the average levelof malondialdehyde was 1.58 umol/mL while in 20 other patients with H. pylori (-), malondialdehyde level was 1.19 umol/mL with p value 0.013.We found the mean serum levels of malondialdehyde was higher in H. pyloripositive gastritis than H. pylori negative.Conclusion: Serum Malondialdehyde level was significantly higher in patient with positive H. pylori gastritiscompared to H. pylori negative gastritis.
Gastrointestinal Problems in HIV/AIDS Patients Zulkhairi Zulkhairi; Imelda Rey; Taufik Sungkar; Lukman Hakim Zain
The Indonesian Journal of Gastroenterology, Hepatology, and Digestive Endoscopy VOLUME 14, NUMBER 3, December 2013
Publisher : The Indonesian Society for Digestive Endoscopy

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (270.147 KB) | DOI: 10.24871/1432013150-153

Abstract

Background: Gastrointestinal (GI) and hepatobiliary disorders are the most common complaints in patients with HIV/AIDS disease. These fundamental problems have not yet been addressed and remains a rewarding area for research. Data about the problems are scarce, especially in Indonesia. This study was aimed to identify gastrointestinal problems in HIV/AIDS patients who were hospitalized in Adam Malik Hospital, Medan.Method: A descriptive study was conducted based on medical records data from non-ambulatory HIV/AIDS patients who had GI problems and who were hospitalized in Internal Medicine wards of Adam Malik Hospital,Medan from 2010-2012. Spearman rank test was used to evaluate the correlation between CD4 level and GI problems among 68 patients with CD4 data.Results: We found 647 HIV/AIDS patients, i.e. 524 (80.9%) male and 123 (19.1%) female patients. Gastrointestinal problems were found in 315 (48.7%) patient among them. Oral candidiasis was the mostcommon case found in 306 (97.1%), which was followed by chronic diarrhea 73 (23.2%), oral candidiasis with chronic diarrhea 64 (20.3%), dyspepsia 22 (6.9%), non-cirrhotic ascites 20 (6.3%), acute diarrhea 8 (2.5%), hepatomegaly 8 (2.5%), dysphagia 6 (1.9%), chronic hepatitis C virus 6 (1.9%), chronic hepatitis B virus 4 (1.3%), GI bleeding 3 (0.9%), and acute hepatitis A virus 1 (0.3%). Unfortunately, we found that therewas only 68 data of CD4. Results of statistical tests showed a significant correlation between CD4 level and gastrointestinal problems (p = 0.04).Conclusion: Oral candidiasis is the most common gastrointestinal problems in HIV/AIDS patients hospitalized in Internal Medicine Wards of Adam Malik Hospital.Keywords: gastrointestinal, HIV/AIDS, oral candidiasis,CD4
Antimicrobial Properties of Pliek U as Traditional Acehnese Fermented Spices Fauzi Satria; Tri Widyawati; Taufik Sungkar
International Journal of Ecophysiology Vol. 6 No. 1 (2024): International Journal of Ecophysiology
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/ijoep.v6i1.15987

Abstract

The high prevalence of antimicrobial resistance globally has increased the burden of disease. The phenomenon demands urgency to explore new antimicrobial drugs, one of which is sourced from natural ingredient, spices. Pliek U, as one of the spices traditionally processed by Acehnese, has attracted researchers to explore its potential source for antimicrobial substances. The objective of this literature review is to explore the characteristic, production, chemical composition, and antimicrobial mechanism of Pliek U. A literature search was carried out on PubMed, Science Direct, Springer Link, and Google Scholar using the keywords "Pliek U”, “Coconut Flesh”, and “Antimicrobial”. The articles obtained were then screened based on predetermined criteria. The results of the analysis were displayed in tabular and narrative form. The final result was 8 main articles and 10 additional articles after screening 65 articles obtained from the database. Pliek U powder is traditionally produced and has unique characteristics that make it easy to recognize. Pliek U mechanism of action based on the chemical composition and the role of lactic acid bacteria in the fermentation process. Analysis shows that Pliek U is a promising antimicrobial source, so it needs to be researched and developed further in the pre-clinical to clinical phases.
Co-Authors Fauzi Satria Gontar Alamsyah Siregar Imelda Rey Laura Dairi Lukman Hakim Zain Munadi Munadi Tri Widyawati