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All Journal Amerta Nutrition World Nutrition Journal
Ida Nurwati
Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia
Health Professions Medicine & Pharmacology Nursing Public Health Other

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Red Rice Bran Extract Intervention Ability to Improve Lipid Profile and Malondialdehyde Levels in Type 2 Diabetes Mellitus Model Rats Isniati Dwijayanti; Brian Wasita; Ida Nurwati
Amerta Nutrition Vol. 6 No. 4 (2022): AMERTA NUTRITION
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v7i4.2022.404-413

Abstract

Background: Diabetes mellitus accompanied by oxidative stress can cause cardiovascular complications. Red rice bran extract contains antioxidants that have the potential to prevent oxidative stress and improve hyperlipidemia in patients with type 2 diabetes mellitus. Objectives: Analyzing the effect of red rice bran extract on lipid profile and malondialdehyde levels in a diabetes mellitus rat model. Methods: Pretest-Posttest Control Group Design. Thirty-five male Wistar Albino rats were divided into 5 groups, namely, negative control, positive control given acarbose as much as 1.8 mg/200gr/day, and 3 treatment groups given red rice bran extract, 165, 330, 660 mg/kg/day for 21 days, respectively. Results: There was a change in lipid profile and MDA levels (p<0.05) after the treatment of bran extract with doses of 165, 330, and 660 mg/kg BW/day. Red rice bran extract at a dose of 660 mg/kg BW/day can be an alternative to acarbose in reducing cholesterol, LDL, and MDA levels, as well as elevating HDL levels in type 2 diabetes mellitus rats. Conclusions: Red rice bran extract can significantly improve lipid profile and malondialdehyde levels in the type 2 diabetes mellitus rat model. Red rice bran extract at a dose of 660 mg/kg BW/day might be used as an alternative to acarbose in improving lipid profiles and MDA levels.
A scoping review : Potential nutraceutical values of bioactive compounds and antioxidant activity in durian seed – An exotic tropical plant Siti Aisyah; Dhani Redhono Harioputro; Ida Nurwati
World Nutrition Journal Vol. 8 No. 2 (2025): WNJ. Volume 08 Issue 2, February 2025
Publisher : Indonesian Nutrition Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25220/WNJ.V08.i2.0001

Abstract

Background: Durian is a tropical fruit with a unique flavour and intense aroma. All parts of durian are reported to have many health benefits, especially the seeds. The seeds are known to have higher antioxidant activity and phytochemical compound than the pulp. Durian seeds are food waste that has the potential to be reused in the food and health industry. Objective: This article provides information on the presence of bioactive compounds, antioxidant activity, and the potential use of durian seeds as therapeutic agents. Methods: The study used a scoping review with four databases: Google Scholar, PubMed, DOAJ, and ScienceDirect. Scoping is needed to complete the article, summarize scientific data, and as a future reference regarding the nutraceutical potential of durian seeds. Results: A total of 6 articles were reviewed based on the screening results. The bioactive compounds found in these articles are phenolics, flavonoids, α-tocopherol, terpenoids, saponins, anthraquinones, and several flavonoid classes such as catechin, rutin, isoquercitrin, quercitrin. Total phenolic content (TPC) and antioxidant activity were highest in the Chanee durian seed cultivar compared to the Monthong type and various other cultivars from several countries. Conclusion: Durian seeds as food waste seem to have potential as a nutraceutical. Known as food waste that is rarely utilized, based on several studies, durian seeds have several benefits, one of which is to overcome various diseases. Further research needs to be done to prove that durian seeds can be helpful in the food industry as well as in pharmaceutical and cosmetic applications.
Co-Authors Brian Wasita Dhani Redhono Harioputro Isniati Dwijayanti Siti Aisyah