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Perbedaan Rasio Neutrofil Limfosit pada Kanker Serviks Tipe Karsinoma Sel Skuamosa dan Tipe Adenokarsinoma Said Nur Ikhsan Fachir; Hariadi Yuseran; F.X. Hendriyono
Homeostasis Vol 5, No 2 (2022)
Publisher : Homeostasis

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Abstract: Cervical cancer is a malignancy and one of the leading causes of death in women. The most common cell types in cervical cancer are squamous cell carcinoma (SCC) (75%) and adenocarcinoma (20%) and the rest are other types (5%). The progression of malignancy can be influenced by the immune system of lymphocytes and neutrophils. The neutrophil lymphocyte ratio is closely related to progression as well as a prognostic marker. A high neutrophil to lymphocyte ratio correlates with a poor patient's prognosis and conversely, the lower the NLR, the better the prognosis. The results obtained 117 research subjects including 88 subjects of cervical cancer type SCC and 29 subjects of adnocarcinoma type cancer recorded at the medical record installation of Ulin Hospital Banjarmasin Period January - December 2019 and as many as 58 subjects (49.7%) met the inclusion criteria including 88 subjects. randomized to 29 subjects (50%) with SCC type and 29 subjects (50%) with adenocarcinoma type. SCC type cervical cancer has a median of 3.37 with a minimum value of 0.77 and a maximum value of 10.98 and adenocarcinoma type has a median of 2.55 with a minimum value of 0.59 and a maximum value of 16.70. The ratio of neutrophil lymphocytes between SCC types and adenocarcinoma types had a p value > 0.05 (0.301). The neutrophil to lymphocyte ratio between types had no significant difference. Keywords: Cervical cancer, NLR, Type SCC and adenocarcinoma Abstrak: Kanker serviks adalah keganasan salah satu penyebab kematian pada wanita. Jenis tipe sel pada kanker serviks paling umum adalah tipe karsinoma sel skuamosa (KSS) (75%) dan tipe adenokarsinoma (20%) dan sisanya merupakan tipe-tipe lain (5%). Progresifitas keganasan dapat dipengaruhi oleh sistem imun limfosit dan neutrofil. Rasio neutrofil limfosit berkaitan erat dengan progresifitas sekaligus penanda prognosis. Rasio Neutrofil Limfosit yang tinggi berkorelasi dengan buruknya prognosis pasien dan sebaliknya semakin rendah RNL maka semakin baik prognosisnya. Hasil penelitian didapatkan 117 subjek penelitian yang meliputi 88 subjek kanker serviks tipe KSS dan 29 subjek kanker tipe adnokarsinoma yang terdata di Instalasi rekam medik RSUD Ulin Banjarmasin Periode Januari – Desember 2019 dan sebanyak 58 subjek (49,7%) memenuhi kriteria inklusi diantaranya 88 subjek di random menjadi 29 subjek (50%) tipe KSS dan 29 subjek (50%) tipe adenokarsinoma. Kanker serviks tipe KSS mempunyai median 3,37 dengan nilai minimun 0,77 dan nilai maksimum 10,98 dan tipe Adenkarsinoma mempunyai median 2,55 dengan nilai minimun 0,59 dan nilai maksimum 16,70. Rasio neutrofil limfosit antar tipe KSS dan tipe adenokarsinoma memiliki nilai p > 0,05 (0,301). Rasio neutrofil limfosit antar tipe memiliki perbedaan yang tidak bermakna. Kata-kata kunci: Kanker serviks, RNL, Tipe KSS dan adenokarsinoma

Perbedaan Rasio Trombosit Limfosit Kanker Serviks Tipe Karsinoma Sel Skuamosa Berdasarkan Diferensiasi Muhammad Eko Fadhli Hendrinanto; Hariadi Yuseran; F.X. Hendriyono
Homeostasis Vol 5, No 2 (2022)
Publisher : Homeostasis

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Abstract: Cervical cancer is the second leading cause of death in women after breast cancer in Indonesia. Cervical cancer has several types of cells, the most common cell type is squamous cell carcinoma (75%), followed by adenocarcinoma (20%) and the rest are other types (5%). The degree of differentiation of cancer cells is the result of microscopic assessment of cancer cells based on the number of cancer cells undergoing mitosis, the similarity of the shape of the cancer cells to the original cells and the homogeneity of the cancer cells. The platelet to lymphocyte ratio (PLR) is related to the degree of cell differentiation. The progression of cervical cancer is influenced by the degree of cell differentiation. The higher of PLR, the worse degree of differentiation of the cancer cells and if the lower of the PLR, the better the degree of differentiation of the cancer cells. The results showed that 88 research subjects were recorded at the medical record installation of RSUD Ulin Banjarmasin and only 46 subjects (52%) met the inclusion criteria including 12 subjects (26%) well differentiated, 28 subjects (61%) moderately differentiated and 6 subjects (13%) ) is poorly differentiated. The mean for well-differentiated SCC obtained a value of 155.6 while the mean for poorly-differentiated SCC obtained a value of 269.9. The median for SCC with moderate differentiation was 208.4, the minimum value was 36.2 and the maximum value was 492.1. The ratio of platelets to lymphocytes between differentiations had no significant difference. Keywords: cervical cancer, degree of cell differentiation, PLR Abstrak: Kanker serviks merupakan salah satu penyebab kematian kedua pada wanita setelah kanker payudara di Indonesia.Kanker serviks mempunyai beberapa tipe sel, tipe sel yang terbanyak adalah tipe karsinoma sel skuamosa (75%), diikuti oleh tipe sel adenokarsinoma (20%) dan sisanya merupakan tipe lain sebanyak (5%). Derajat diferensiasi sel kanker adalah hasil dari penilaian mikroskopis sel kanker berdasarkan jumlah sel kanker yang mengalami mitosis, kemiripan bentuk sel kanker dengan sel asal dan susunan homogenitas dari sel kanker. Rasio trombosit limfosit (RTL) berhubungan dengan derajat diferensiasi sel. Progresivitas kanker serviks dipengaruhi derajat diferensiasi sel. Semakin tinggi RTL maka semakin buruk juga derajat diferensiasi dan sebaliknya semakin rendah RTL maka semakin baik derajat diferensiasi. Hasil penelitian didapatkan 88 subjek penelitian yang terdata di Instalasi rekam medik RSUD Ulin Banjarmasin dan hanya 46 subjek (52%) memenuhi kriteria inklusi diantaranya 12 subjek (26%) berdiferensiasi baik, 28 subjek (61%) berdiferensiasi sedang dan 6 subjek (13%) berdiferensiasi buruk. Rerata untuk KSS diferensiasi baik didapatkan nilai 155,6 sedangkan rerata untuk KSS diferensiasi buruk didapatkan nilai 269,9. Median untuk KSS diferensiasi sedang didapatkan nilai 208,4, nilai minimum didapatkan 36,2 dan nilai maksimum didapatkan 492,1. Rasio trombosit limfosit antar diferensiasi memiliki perbedaan yang tidak bermakna. Kata-kata kunci: kanker serviks tipe KSS, derajat diferensiasi sel, RTL

Perbedaan Rasio Neutrofil Limfosit Kanker Serviks Tipe Karsinoma Sel Skuamosa Berdasarkan Diferensiasi Ghaitsa Zahira Shofa; Hariadi Yuseran; F.X. Hendriyono
Homeostasis Vol 5, No 2 (2022)
Publisher : Homeostasis

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Abstract: Cervical cancer has several cell types, squamous cell carcinoma, adenocarcinoma and others. The level of progression of cervical cancer is determined by the degree of cell differentiation, which is classified into well, moderate and poor differentiation. The neutrophil lymphocyte ratio (NLR) can assess the progression of cervical cancer. The higher the NLR, the higher the level of progression and the worse the degree of cell differentiation. This research is an analytical study using secondary data. The results obtained were 88 cervical cancer subjects with squamous cell carcinoma type and only 41 subjects (46,6%) included in inclusion criteria of this study. In this study, there were 9 subjects of cervical cancer squamous cell carcinoma type with well-differentiated (22,0%), 26 subjects with moderately differentiated (63,5%) and 6 subjects with poorly differentiated (14,5%). The results of NLR for cervical cancer squamous cell carcinoma type well-differentiated has a mean of 1,5 with standard deviation of 1,2. The results of NLR for cervical cancer squamous cell carcinoma type moderately-differentiated has a mean of 3,4 with standard deviation of 2,3. The results of NLR for cervical cancer squamous cell carcinoma type poorly-differentiated has a mean of 5,5 with standard deviation of 3,7. Conclusion from this study is there was a significant difference of NLR in cervical cancer squamous cell carcinoma type in each differentiation. Keywords: cervical cancer squamous cell carcinoma type; well, moderately and poorly differentiated; NLR Abstrak: Kanker serviks mempunyai beberapa tipe sel, yaitu tipe karsinoma sel skuamosa, adenokarsinoma dan lain-lain. Tingkat progresivitas kanker serviks ditentukan dengan derajat diferensiasi sel, yang dibedakan menjadi diferensiasi baik, sedang dan buruk. Rasio neutrofil limfosit (RNL) dapat menilai progresivitas kanker serviks. Semakin tinggi RNL, maka semakin tinggi juga tingkat progresivitasnya dan derajat diferensiasi selnya semakin buruk. Penelitian ini bersifat studi analitik dengan menggunakan data sekunder. Hasil penelitian diperoleh 88 subjek kanker serviks tipe karsinoma sel skuamosa dan hanya 41 subjek (46,6%) yang memenuhi kriteria inklusi penelitian. Pada penelitian ini, terdapat 9 subjek kanker serviks tipe karsinoma sel skuamosa diferensiasi baik (22,0%), 26 subjek diferensiasi sedang (63,5%) dan 6 subjek diferensiasi buruk (14,5%). Hasil data RNL pada kanker serviks tipe karsinoma sel skuamosa diferensiasi baik memiliki rerata 1,5 dengan simpang baku 1,2. Hasil data RNL pada kanker serviks tipe karsinoma sel skuamosa diferensiasi sedang memiliki rerata 3,4 dengan simpang baku 2,3. Hasil data RNL kanker serviks tipe karsinoma sel skuamosa diferensiasi buruk memiliki rerata 5,5 dengan simpang baku 3,7. Kesimpulannya terdapat perbedaan bermakna RNL pada kanker serviks tipe karsinoma sel skuamosa antar diferensiasi. Kata-kata kunci: kanker serviks tipe karsinoma sel skuamosa; derajat diferensiasi baik, sedang dan buruk; RNL

Perbedaan Rasio Trombosit Limfosit pada Kanker Serviks Tipe Karsinoma Sel Skuamosa dan Adenokarsinoma Bella Aprilia Damayanti; Hariadi Yuseran; F.X. Hendriyono
Homeostasis Vol 5, No 2 (2022)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (229.779 KB)

Abstract: Cervical cancer is an abnormal cell growth that leads to malignancy in the cervix. Cervical cancer has several cell types including squamous cell carcinoma (SCC) and adenocarcinoma type. The progression of cervical cancer is influenced by many factors, including platelets and the immune system, namely lymphocytes. The ratio of platelets to lymphocytes affects the progression and prognostic markers of cervical cancer. This study aims to determine whether there are differences in RTL in cervical cancer type SCC and adenocarcinoma. The results showed that 58 subjects with cervical cancer, 29 subjects with SCC type and 29 subjects with adenocarcinoma type. The mean RTL value for cervical cancer with SCC type was 196.4 and standard deviation was 105.3 and the mean RTL value for adenocarcinoma type was 163.9 and standard deviation was 59.0. The conclusion of this study is that there is a significant difference in RTL in cervical cancer type SCC and adenocarcinoma with p = 0.000. Keywords: cervical cancer, SCC, adenocarcinoma, RTL Abstrak: Kanker serviks merupakan pertumbuhan sel abnormal yang mengarah pada keganasan di leher rahim. Kanker serviks memiliki beberapa tipe sel diantaranya ada tipe karsinoma sel skuamosa (KSS) dan tipe adenokarsinoma. Progresivitas kanker serviks dipengaruhi banyak faktor, diantaranya trombosit dan sistem imun yaitu limfosit. Rasio trombosit limfosit mempengaruhi progresivitas dan penanda prognostik pada kanker serviks. Penelitian ini bertujuan untuk mengetahui apakah ada perbedaan RTL pada kanker serviks tipe KSS dan adenokarsinoma. Hasil penelitian didapatkan 58 subjek kanker serviks, 29 subjek tipe KSS dan 29 subjek tipe adenokarsinoma. Hasil rerata nilai RTL pada kanker serviks tipe KSS adalah 196,4 dan simpang baku105,3 dan rerata nilai RTL pada tipe adenokarsinoma adalah 163,9 dan simpang baku 59,0. Kesimpulan penelitian ini adalah terdapat perbedaan bermakna RTL pada kanker serviks tipe KSS dan adenokarsinoma dengan p=0,000. Kata – kata kunci : kanker serviks, KSS, adenokarsinoma, RTL

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