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All Journal Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Selli Muljanto
Universitas Lambung Mangkurat
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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GAMBARAN KADAR HORMON FT4 DAN TSH PADA ANAK SINDROM NEFROTIK DI RSUD ULIN BANJARMASIN Larissa Faisa Faisa; FX Hendriyono; Selli Muljanto
Homeostasis Vol 2, No 3 (2019)
Publisher : Homeostasis

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Abstract:. One of the complications of nephrotic syndrome is hypothyroidism. Hypothyroidism in nephrotic syndrome is caused by glomerular filtration damage and proximal tubule dysfunction which causes the FT4 loss into urine. Hypothyroidism in children can cause delay in growth and disruption of the body's metabolism. The aim of this study was to describe the hormone levels of FT4 and TSH in children with nephrotic syndrome in relapsing phase and steroid-resistant nephrotic syndrome in Ulin General Hospital Banjarmasin in the period January 2017 - August 2018. The study sample consisted of 12 pediatric nephrotic syndrome patients who had met the inclusion criteria. The research is the descriptive research with a retrospective cross sectional approach. Result shown that of 12 patients consisting of 6 NS in relapsing phase and 6 SRNS, the overall FT4 levels were 20.31 ± 7.72, and TSH 4.5 ± 4.3 The mean FT4 levels in relapsing were 17.34 ± 3 and in SRNS 17.34, while TSH levels in relapsing  4.9 ± 5.3 and in SRNS 4.03 ± 3.42. This shows overall levels of FT4 and TSH normal, so it can be concluded that in children with relapsing and resistant nephrotic syndrome in Ulin General Hospital Banjarmasin don’t have hypothyroidism. Keywords: FT4 level, TSH level, relaps nephrotic syndrome, steroid resistant nephrotic syndrome (SRNS) Abstrak: Salah satu komplikasi dari sindrom nefrotik adalah hipotiroid. Hipotiroid pada sindrom nefrotik disebabkan karena adanya kerusakan filtrasi glomerulus dan disfungsi tubulus proksimal yang menyebabkan FT4 terbuang lewat urin. Hipotiroid pada anak dapat menyebabkan keterlambatan tumbuh kembang dan gangguan metabolisme tubuh. Tujuan dari penelitian ini untuk mengetahui gambaran kadar hormon FT4 dan TSH pada anak sindrom nefrotik relap dan sindrom nefrotik resisten steroid di RSUD Ulin Banjarmasin periode Januari 2017 – Agustus 2018. Sampel penelitian terdiri dari 12 orang pasien anak sindrom nefrotik yang telah memenuhi kriteria inklusi. Penelitian yang dilakukan bersifat deskriptif dengan pendekatan cross sectional  retrospektif. Hasil penelitian menunjukan dari 12 orang pasien SN, terdiri dari 6 orang SN relaps dan 6 orang SNRS secara keseluruhan rerata kadar FT4 20,31 ± 7,72, dan TSH 4,5 ± 4,3. Rerata kadar FT4 pada SN Relaps 17,34±3 dan pada SNRS 17,34, sedangkan kadar TSH pada SN Relaps 4,9± 5,3 dan pada SNRS 4,03± 3,42.  Hal ini menunjukan secara keseluruhan kadar FT4 dan TSH normal, sehingga dapat disimpulkan pada anak sindrom nefrotik relaps dan resisten di RSUD Ulin Banjarmasin tidak mengalami hipotiroid Kata-kata kunci: Kadar FT4, kadar TSH, sindrom nefrotik relap, sindrom nefrotik resisten steroid
GAMBARAN KADAR KALSIUM TOTAL DAN VITAMIN D PADA ANAK SINDROM NEFROTIK DI RSUD ULIN BANJARMASIN Nurul Muth Mainnah; FX Hendriyono; Selli Muljanto
Homeostasis Vol 2, No 3 (2019)
Publisher : Homeostasis

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Abstract: Complications nephrotic syndrome (NS) include hypocalcaemia and vitamin D deficiency. That are due to increased glomerular permeability of protein. This study aimed to describe the total calcium and vitamin D levels in children with relapse NS, steroid-dependent NS and steroid-resistant NS (SRNS) at Ulin General Hospital Banjarmasin on January 2017-August 2018. This research method with a retrospective cross-sectional approach. There were 21 subjects consisted of relapse NS (38.1%), steroid dependent NS (33.3%) and SRNS (28.6%) were selected by purposive sampling according to inclusion criteria. The results of the study on NS children at Ulin General Hospital Banjarmasin were found to have a mean total calcium levels of 9.35±1.55 mg/dL and a mean vitamin D levels of 19.85±8.79 ng/mL. Furthermore, the mean total calcium levels in relapse NS was 9.43±1.72 mg/dL, steroid dependent NS 9.46±1.29 mg/dL and SRNS 9.12±1.83 mg/dL and the mean vitamin D levels in relapsed NS 19.56±6.17 ng/mL, steroid-dependent NS 21.73±10.46 ng/mL, SRNS 18.03±10.79 ng/mL. It can be concluded that in children with relapse NS, steroid-dependent NS and SRNS at Ulin General Hospital Banjarmasin have a normal mean total calcium levels and decreased a mean of vitamin D levels. Keywords: nephrotic syndrome, relapse nephrotic syndrome, steroid-dependent nephrotic syndrome,   steroid-resistant nephrotic syndrome, total calcium, vitamin D. Abstrak: Komplikasi sindrom nefrotik (SN) diantaranya hipokalsemia dan defisiensi vitamin D. Hal tersebut disebabkan meningkatnya permeabilitas glomerulus terhadap protein. Penelitian ini bertujuan untuk mengetahui gambaran kadar kalsium total dan vitamin D pada pasien SN relaps, SN dependen steroid dan SN resisten steroid (SNRS) di RSUD Ulin Banjarmasin periode Januari 2017-Agustus 2018. Metode penelitian dengan pendekatan cross sectional retrospektif. Didapatkan 21 subjek terdiri dari SN relaps (38,1%), SN dependen steroid (33,3%) dan SNRS (28,6%) dipilih melalui purposive sampling yang memenuhi kriteria inklusi. Hasil penelitian pada pasien SN anak didapatkan rerata kadar kalsium total 9,35±1,55 mg/dL dan rerata kadar vitamin D 19,85±8,79 ng/mL. Selanjutnya rerata kadar kalsium total pada SN relaps 9,43±1,72 mg/dL, SN dependen steroid 9,46±1,29 mg/dL dan SNRS 9,12±1,83 mg/dL serta rerata kadar vitamin D pada SN relaps 19,56±6,17 ng/mL, SN dependen steroid 21,73±10,46 ng/mL, SNRS 18,03±10,79 ng/mL. Dapat disimpulkan pada pasien SN relaps, SN dependen steroid dan SNRS di RSUD Ulin Banjarmasin memiliki rerata kadar kalsium total yang normal dan rerata kadar vitamin D yang menurun. Kata-kata kunci: sindrom nefrotik, sindrom nefrotik relaps, sindrom nefrotik dependen steroid, sindrom nefrotik resisten steroid, kalsium total, vitamin D
PERBEDAAN KADAR KOLESTEROL TOTAL DAN TRIGLISERIDA PADA ANAK SINDROM NEFROTIK RELAPS DAN REMISI DI RSUD ULIN BANJARMASIN Siti Annisa Rezki; FX Hendriyono; Selli Muljanto
Homeostasis Vol 2, No 3 (2019)
Publisher : Homeostasis

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Abstract

Abstract: Hyperlipidemia is one of an important characteristics of nephrotic syndrome (NS). This study aims to determine the differences between total cholesterol and triglyceride levels in childrens with relapse and remission NS in Ulin General Hospital Banjarmasin from January 2017 - August 2018. A total of 26 childrens with NS were selected by purposive sampling method according to inclusion criteria. Among these, 15 childrens were in relapse and 11 childrens were in remission. Hypercholesterolemia were found in 93% of childrens with relapse NS and in 27% of childrens with remission NS, while hypertriglyceride were found in 67% of childrens with relapse NS and in 36% of childrens with remission NS. The mean total cholesterol levels in childrens with relapse NS is 374±38 mg/dL, was higher than those in remission, which is 168±12 mg/dL. The mean triglyceride levels in childrens with relapse NS is 267±186 mg/dL, also higher than those in remission, which is 130±78 mg/dL. The results of the analysis using an unpaired T test with a confidence level of 95%. This study can concluded that there were significant differences between total cholesterol (p = 0,000) and triglyceride levels (p = 0,030) in children with relapse and remission NS. Keywords: relaps nephrotic syndrome, nephrotic syndrome, remission, total cholesterol, triglyceride Abstrak: Hiperlipidemia merupakan karakteristik penting pada sindrom nefrotik (SN). Penelitian ini bertujuan untuk mengetahui perbedaan kadar kolesterol total dan trigliserida pada anak SN relaps dan remisi di RSUD Ulin Banjarmasin periode Januari 2017 – Agustus 2018. Sebanyak 26 anak SN yang terbagi atas 15 SN relaps dan 11 SN remisi dipilih secara purposive sampling sesuai kriteria inklusi. Didapatkan kejadian hiperkolesterolemia sebanyak 93% pada SN relaps dan 27% pada SN remisi, sedangkan kejadian hipertrigliseridemia sebanyak 67% pada SN relaps dan 36% pada SN remisi. Rerata kadar kolesterol total dan trigliserida pada SN relaps lebih tinggi dari SN remisi. Rerata kadar kolesterol total pada SN relaps adalah 374±38 mg/dL dan SN remisi adalah 168±12 mg/dL. Rerata kadar trigliserida pada SN relaps adalah 267±186 mg/dL dan SN remisi adalah 130±78 mg/dL. Hasil analisis menggunakan uji T tidak berpasangan dengan tingkat kepercayaan 95%. Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa terdapat perbedaan bermakna antara kadar kolesterol total (p=0,000) dan trigliserida (p=0,030) pada anak SN relaps dan remisi. Kata-kata kunci: sindrom nefrotik relaps, sindrom nefrotik, remisi, kolesterol total, trigliserida
Co-Authors FX Hendriyono Larissa Faisa Faisa Nurul Muth Mainnah Siti Annisa Rezki