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All Journal Homeostasis: Jurnal Mahasiswa Pendidikan Dokter
Oky Susianto
RSUD Ulin
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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Kadar Protein C-Reaktif Pasien Sepsis dan Non-Sepsis di Ruang Rawat Intensif RSUD Ulin Banjarmasin Nurmalita Insani Haq; Oky Susianto; Rahmiati Rahmiati
Homeostasis Vol 3, No 3 (2020)
Publisher : Homeostasis

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Abstract

Abstract: Sepsis is a high mortality disease with a in intensive care unit. CRP is expected to be a marker of sepsis. CRP is an acute phase biomarker which the increase is induced by proinflamatory cytokines. The purpose of this study was to determine sepsis and nonsepsis patients in the ICU based on qSOFA scores, CRP levels and patient outcomes in the period August - October 2019. This research was a descriptive observational prospect with repeated measurement of CRP levels. The sampling technique used was consecutive sampling. The study population was all patients in the intensive care unit of Ulin General Hospital Banjarmasin in the period August - October 2019. The diagnosis of sepsis was made using the qSOFA score. CRP levels were measured on ICU admission and 3 days after respectively. The results of this study included of 25 patients, consisted of 14 sepsis patients and 11 nonsepsis patients. The CRP level average of sepsis patients was at H0 (35.07 ± 31.53); H1 (15.85 ± 15.54); H2 (19.28 ± 18.25) and H3 (12.54 ± 14.8). Keywords: CRP, mortality, sepsis. Abstrak: Sepsis merupakan penyakit dengan angka kematian yang tinggi di ruang rawat intensif. CRP diperkirakan dapat menjadi salah satu penanda diagnosis sepsis. CRP merupakan biomarker fase akut yang peningkatannya diinduksi oleh sitokin proinflamasi. Tujuan penelitian ini yaitu mengetahui gambaran pasien sepsis dan nonsepsis di ICU berdasarkan skor qSOFA, kadar CRP dan luaran pasien pada periode Agustus – Oktober 2019. Jenis penelitian ini adalah observasional deskriptif yang bersifat prospektif, dengan pengukuran berulang terhadap kadar CRP. Teknik sampling yang digunakan adalah consecutive sampling. Populasi penelitian adalah seluruh pasien di ruang rawat intensif RSUD Ulin Banjarmasin pada periode Agustus – Oktober 2019. Penegakkan diagnosis sepsis dilakukan menggunakan skor qSOFA. Pengukuran kadar CRP dilakukan saat pasien masuk ICU dan 3 hari setelahnya secara berturut-turut. Hasil penelitian ini terdiri dari 25 pasien, dengan 14 pasien sepsis dan 11 pasien non sepsis. Rata-rata kadar CRP pasien sepsis pada H0 (35.07±31.53); H1 (15.85±15.54); H2 (19.28±18.25) dan H3 (12.54±14.8). Kata-kata kunci: CRP, mortalitas, sepsis.
Jumlah Eosinofil Pasien Sepsis dan Nonsepsis di Ruang Rawat Intenif RSUD Ulin Banjarmasin Marisa Izza Mawaddah; Oky Susianto; Rahmiati Rahmiati
Homeostasis Vol 3, No 3 (2020)
Publisher : Homeostasis

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (264.175 KB)

Abstract

Abstract: Eosinophils are an immunomodulator which is routine to check in every hospital because it is cheap and easy to do. Eosinophils are ideal biomarkers of sepsis and nonsepsis. The use of qSOFA can describe quantitatively and objectively to identify sepsis patients earlier. So that high sepsis cases and treatment costs can be reduced. The purpose of this study was to determine sepsis and nonsepsis patients in the ICU based on qSOFA scores, the number of eosinophils and outcomes of patients treated at the ICU RSUD Ulin Banjarmasin in the August-October 2019 period. The design of the study was a descriptive observational. In this study found 31 participants who met with consecutive sampling techniques. The number of sepsis patients was 16 people and nonsepsis patients was 15 people. The average of eosinophils of sepsis patients was 30 cells/mm3 (T0), 78.18 cells/mm3 (T1), and 184.55 cells/mm3 (T2). While nonseptic patients was 24.57 cells/mm3 (T0), 42.00 cells/mm3(T1), and 107.33 cells/mm3 (T2). In sepsis, 68.75% of patients survived and 31.25% died. Whereas the output of 100% nonseptic patient survives. Keyword: eosinophils, ICU, qSOFA, outcome, sepsis Abstract: Eosinofil merupakan immunomodulator yang rutin diperiksa di setiap rumah sakit karena biayanya murah dan mudah dilakukan. Sehingga menjadi biomarker sepsis dan nonsepsis yang ideal. Penggunaan qSOFA secara kuantitatif dan objektif dapat mengidentifikasi pasien sepsis lebih dini. Sehingga kejadian dan biaya perawatan sepsis yang tinggi dapat ditekan. Tujuan penelitian ini adalah untuk menentukan pasien sepsis dan nonsepsis di ICU berdasarkan skor qSOFA, jumlah eosinofil dan luaran pasien yang dirawat di ICU RSUD Ulin Banjarmasin periode Agustus-Oktober 2019. Rancanga penelitian ini deskriptif observasional. Didapatkan 31 partisipan dengan teknik pengambilan sampel consecutive dengan 16 orang sepsis dan 15 orang nonsepsis. Rerata jumlah eosinofil pasien adalah 30 sel/mm3 (T0), 78,18 sel/mm3 (T1), dan 184,55 sel/mm3 (T2). Sedangkan pasien nonsepsis adalah 24,57 sel/mm3 (T0), 42,00 sel/mm3 (T1), dan 107,33 sel/mm3 (T2). Luaran pasien sepsis 68,75% bertahan hidup dan 31,25% meninggal dan luaran pasien nonsepsis 100% bertahan hidup. Kata-kata kunci: eosinofil, ICU, luaran, qSOFA, sepsis
Co-Authors Marisa Izza Mawaddah Nurmalita Insani Haq Rahmiati Rahmiati