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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Bioscientia Medicina : Journal of Biomedicine and Translational Research
Athuf Thaha
Lecturer of Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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The Role of Oxidative Stress in Atopic Dermatitis Nopriyati; Rina Novriani; Athuf Thaha; Sarah Diba; Yulia Farida Yahya; Inda Astri Aryani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 11 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i11.603

Abstract

Atopic dermatitis (AD) is a chronic skin inflammation found in children with a varied course caused by external and internal factors. The incidence of AD in industrialized countries is 10-20% in children and 1-3% in adults. The main etiopathogenesis of AD is genetic and skin barrier disorders, immunologic disorders, and environment. Oxidative stress (SO) is the accumulation of reactive oxygen species (ROS) that exceeds the defense capacity of the body's antioxidant system. Uncontrolled ROS production plays a major role in various skin diseases. Oxidative stress can damage the deoxyribonucleic acid (DNA) of keratinocytes through lipid oxidation, as well as disrupt skin barrier function, increase the production of proinflammatory cytokines and worsen AD lesions. The main objectives of this literature review are to determine the role of oxidative stress in AD and antioxidants as adjunctive therapy.
The Role of Oxidative Stress in Atopic Dermatitis Nopriyati; Rina Novriani; Athuf Thaha; Sarah Diba; Yulia Farida Yahya; Inda Astri Aryani
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 11 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i11.603

Abstract

Atopic dermatitis (AD) is a chronic skin inflammation found in children with a varied course caused by external and internal factors. The incidence of AD in industrialized countries is 10-20% in children and 1-3% in adults. The main etiopathogenesis of AD is genetic and skin barrier disorders, immunologic disorders, and environment. Oxidative stress (SO) is the accumulation of reactive oxygen species (ROS) that exceeds the defense capacity of the body's antioxidant system. Uncontrolled ROS production plays a major role in various skin diseases. Oxidative stress can damage the deoxyribonucleic acid (DNA) of keratinocytes through lipid oxidation, as well as disrupt skin barrier function, increase the production of proinflammatory cytokines and worsen AD lesions. The main objectives of this literature review are to determine the role of oxidative stress in AD and antioxidants as adjunctive therapy.
Co-Authors Inda Astri Aryani Nopriyati Rina Novriani Sarah Diba Yulia Farida Yahya