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All Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Sriwijaya Journal of Surgery Bioscientia Medicina : Journal of Biomedicine and Translational Research
Irsan Saleh
Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience

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Correlation of IL-17 Serum Levels with Carotid Intima-Media Thickness and Degree of Disease Activity in Rheumatoid Arthritis Patients at Dr. Mohammad Hoesin General Hospital Palembang, Indonesia Lingga Gumelar; Hermansyah; Radiyati; Taufik Indrajaya; Zulkhair Ali; Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 12 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i12.623

Abstract

Background: Rheumatoid arthritis (AR) is an autoimmune disease characterized by chronic and progressive systemic inflammation, in which the joints are the main target. AR has long been associated with increased cardiovascular risk. Vascular inflammation plays an important role in atherosclerosis. In AR, there is an increase in IL-17, which accelerate the formation of atherosclerosis. In Indonesia alone, there is no data that publishes the correlation between IL-17 levels with carotid IMT and the severity of AR. Methods: This type of research is a descriptive observational study with a correlation test approach. A total of 31 subjects participated in this study who were AR patients and calculated a DAS score of 28. Carotid IMT was measured by high-resolution carotid Doppler ultrasound B-mode ultrasound machine (PHILIPS, iE33) equipped with an 11 MHz linear array transducer. IL-17 was measured by the ELISA method. Data analysis was performed with a correlation test with SPSS software version 25. Results: There was a strong positive correlation between IL-17 and the degree of disease activity in AR (DAS28 score) with r = 0.657; p = 0.0001; n=31. There was no significant correlation between carotid IMT and IL-17 levels (r= 0,207; p=0,264; n=31). Conclusion: There is a strong positive correlation between IL-17 and the degree of AR disease activity. There was no significant correlation between carotid IMT and IL-17 levels.
Correlation of IL-17 Serum Levels with Carotid Intima-Media Thickness and Degree of Disease Activity in Rheumatoid Arthritis Patients at Dr. Mohammad Hoesin General Hospital Palembang, Indonesia Lingga Gumelar; Hermansyah; Radiyati; Taufik Indrajaya; Zulkhair Ali; Irsan Saleh
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 12 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i12.623

Abstract

Background: Rheumatoid arthritis (AR) is an autoimmune disease characterized by chronic and progressive systemic inflammation, in which the joints are the main target. AR has long been associated with increased cardiovascular risk. Vascular inflammation plays an important role in atherosclerosis. In AR, there is an increase in IL-17, which accelerate the formation of atherosclerosis. In Indonesia alone, there is no data that publishes the correlation between IL-17 levels with carotid IMT and the severity of AR. Methods: This type of research is a descriptive observational study with a correlation test approach. A total of 31 subjects participated in this study who were AR patients and calculated a DAS score of 28. Carotid IMT was measured by high-resolution carotid Doppler ultrasound B-mode ultrasound machine (PHILIPS, iE33) equipped with an 11 MHz linear array transducer. IL-17 was measured by the ELISA method. Data analysis was performed with a correlation test with SPSS software version 25. Results: There was a strong positive correlation between IL-17 and the degree of disease activity in AR (DAS28 score) with r = 0.657; p = 0.0001; n=31. There was no significant correlation between carotid IMT and IL-17 levels (r= 0,207; p=0,264; n=31). Conclusion: There is a strong positive correlation between IL-17 and the degree of AR disease activity. There was no significant correlation between carotid IMT and IL-17 levels.
Prognotic Test for Mortality and Morbidity Using Procalcitonin and C-Reactive Protein Values in Elderly Patients Post Hip Joint Arthroplasty at Dr. Mohammad Hosein General Hosital Palembang Nur Rachmat Lubis; Diah Mirlia; Irsan Saleh
Sriwijaya Journal of Surgery Vol. 3 No. 2 (2020): Sriwijaya Journal of Surgery
Publisher : Surgery Department, Faculty of Medicine Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/sjs.v2i2.28

Abstract

Background: Pelvic arthroplasty in the elderly is increasingly being performed, along with the increasing life expectancy in Indonesia. However, postoperative mortality must be taken into account. Methods: Prospective cohort study of mortality and morbidity up to 30 days in 38 patients who met the inclusion criteria. The observation of changes in the value of Procalcitonin and C-Reactive Protein was carried out preoperatively, after surgery on day 2 and after surgery on day 7. Results: There was no mortality. There was 18% redness output in the analyzed surgical wound. The cut off of Procalcitonin used Fisher's Exact test (RR = 3.088, p = 0.207), while the cut off of C-Reactive Protein used Fisher's Exact test (RR = 1.647, p = 0.678). Conclusion: There was no significant relationship between procalcitonin levels and C-reactive protein and postoperative redness.
Co-Authors Diah Mirlia Hermansyah Lingga Gumelar Nur Rachmat Lubis Radiyati Taufik Indrajaya Zulkhair Ali