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All Journal Indonesian Journal of Global Health research Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Santi Syafril
Universitas Sumatera Utara
Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health

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HUBUNGAN RESISTENSI INSULIN DENGAN DERAJAT KEPARAHAN COVID-19 PADA PASIEN DIABETES MELITUS TIPE 2 Priska Krinanta Ginting; Dharma Lindarto; Santi Syafril
Al-Iqra Medical Journal : Jurnal Berkala Ilmiah Kedokteran Vol 5, No 2 (2022): ILMU KEDOKTERAN
Publisher : Journal Medical Universitas muhammadiyah Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26618/aimj.v5i2.8027

Abstract

Resistensi Insulin (IR) mungkin merupakan faktor kunci potensial di balik derajat keparahan COVID-19 namun di Indonesia sendiri, belum ada data mengenai hubungan resistensi insulin terhadap derajat keparahan COVID-19, khususnya yang menggunakan pemeriksaan HOMA IR. Untuk mengetahui hubungan resistensi insulin dengan derajat keparahan COVID-19 pada pasien Diabetes Melitus tipe 2. Penelitian ini dengan rancangan analitik cross sectional dengan pengambilan data secara prospektif dengan sumber rekam medis yang di rawat inap isolasi RSUP Haji Adam Malik Medan dari bulan Juni 2021 – September 2021 pada pasien yang terdiagnosa COVID-19 dengan komorbid diabetes mellitus yang memenuhi kriteria inklusi dan eksklusi. Untuk analisis resistensi insulin berdasarkan skor HOMA-IR dengan derajat keparahan COVID-19 berdasarkan manifestasi klinis yang muncul (ringan, sedang, berat, dan kritis) dilakukan uji chi square dan dinyatakan bermakna apabila nilai p 0.05. Mayoritas subjek penelitian memiliki skor HOMA-IR 3,8 sebanyak 35 orang, 21 orang (60,0%) di antaranya merupakan COVID-19 derajat berat dan 8 orang (22,9%) di antaranya merupakan COVID-19 derajat sedang, 6 orang (17,1%) di antaranya merupakan COVID-19 derajat kritis. Subjek penelitian yang memiliki skor HOMA-IR 2,6 sebanyak 32 orang, 24 orang (75,0%) di antaranya merupakan COVID-19 derajat sedang, 7 orang (21,9%) di antaranya merupakan COVID-19 derajat berat dan 1 orang (3,1%) di antaranya merupakan COVID-19 derajat kritis. Subjek penelitian yang memiliki skor HOMA-IR 2,6-3,8 sebanyak 7 orang, 4 orang (57,1%) diantaranya merupakan COVID-19 derajat sedang, 2 orang (28,6%) di antaranya merupakan COVID-19 derajat berat dan 1 orang (14,3%) di antaranya merupakan COVID-19 derajat kritis. Terdapat perbedaan yang signifikan antara skor HOMA-IR dengan derajat keparahan COVID-19 secara statistik. 
Corelation Between Uric Acid and Neutrophil Lymphocyte Ratio (NLR) in Controlled and Uncontrolled Type 2 Diabetes Mellitus Immanuel Situmorang; Jelita Siregar; Santi Syafril
Indonesian Journal of Global Health Research Vol 7 No 5 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i5.6986

Abstract

Type 2 diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycemia, often linked to metabolic complications and inflammatory conditions. Uric acid and Neutrophil-Lymphocyte Ratio (NLR) are biomarkers of inflammation and oxidative stress in this condition. This study aims to examine the relationship between uric acid and NLR in controlled and uncontrolled type 2 DM patients. Using an analytical observational design with a cross-sectional approach and consecutive sampling, 112 subjects were divided into controlled (HbA1c < 7%) and uncontrolled (HbA1c ≥ 7%) groups. Data were collected from RSUP H. Adam Malik Medan through laboratory tests for whole blood, uric acid, and HbA1c levels. Pearson or Spearman correlation tests were used to assess relationships between variables with a significance level of p < 0.05. Significant demographic differences were found between groups, with higher uric acid and HbA1c levels in the uncontrolled DM group. Positive correlations were observed between uric acid and NLR, as well as uric acid and HbA1c, in both groups. Additionally, a strong positive association between HbA1c and NLR was found in both groups. Uric acid, NLR, and HbA1c are correlated in both controlled and uncontrolled type 2 diabetes mellitus.
The Correlation Between Visceral Fat Levels and Fasting Blood Glucose in Type 2 Diabetes Patients at Primary Health Facility in Medan Aisy Putri; Dina Keumala Sari; Fitriyani Nasution; Santi Syafril; M. Aron Pase; Jennifer Setiawan
Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI) Vol. 8 No. 1 (2026): Journal of Endocrinology, Tropical Medicine, and Infectious Disease (JETROMI)
Publisher : TALENTA Publisher, Universitas Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jetromi.v8i1.24782

Abstract

Introduction: Type 2 diabetes mellitus (T2DM) is a major metabolic disorder closely linked to visceral adiposity and insulin resistance. Visceral fat is metabolically active and contributes to inflammation and impaired glucose regulation. Evidence regarding the association between visceral fat and fasting blood glucose in primary healthcare populations remains limited. This study aimed to examine the correlation between visceral fat levels and fasting blood glucose among patients with T2DM in a primary care setting. Methods: This cross-sectional analytic study was conducted at a primary healthcare facility in Medan between October and December 2025. Sixty adult patients with confirmed T2DM were recruited using consecutive sampling. Visceral fat levels were measured using bioelectrical impedance analysis, and fasting blood glucose was assessed after an overnight fast using standardized laboratory methods. Sociodemographic and clinical variables were recorded. Data distribution was tested using the Kolmogorov–Smirnov test, and correlation analysis was performed using Spearman’s rho with a significance level of p<0.05. Results: Participants had a median age of 63.5 years, and 61.7% were female. The median body mass index was 25.4 kg/m² and median fasting blood glucose was 154 mg/dL. Both visceral fat and fasting glucose were non-normally distributed (p<0.001). Correlation analysis demonstrated a weak positive association between visceral fat and fasting blood glucose (r=0.173), which was not statistically significant (p=0.186). Discussion: The findings suggest that fasting glycemic status in established T2DM is influenced by multifactorial mechanisms beyond adiposity alone, including treatment effects and disease progression. Conclusion: Although non-significant, the positive trend supports the metabolic relevance of visceral adiposity. Assessment of visceral fat remains important for cardiometabolic risk evaluation in primary care. Keywords: Diabetes Mellitus, Type 2; Visceral Fat; Blood Glucose; Obesity, Abdominal
Co-Authors Aisy Putri dharma Lindarto, dharma Dina Keumala Sari Fitriyani Nasution Immanuel Situmorang Jelita Siregar Jennifer Setiawan M. Aron Pase Priska Krinanta Ginting