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All Journal Indonesian Journal of Cancer Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia
TRI APRILIAWAN, TRI
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Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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Akurasi Kadar Lysophosphatidic Acid Plasma dan Ca125 Serum Penderita Tumor Ovarium Jenis Epitel untuk Prediktor Keganasan Ovarium APRILIAWAN, TRI; ASKANDAR, BRAHMANA
Indonesian Journal of Cancer Vol 8, No 2 (2014): April-Juni 2014
Publisher : "Dharmais" Cancer Center Hospital

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Abstract

This study was conducted to determine and compare the sensitivity, specificity, positive predictive value and negative predictive value between CA125, Lysophosphatidic Acid Plasma (LPA) and combination of LPA - CA125 in patients with ovarian mass.This study was a analytic observational cross sectional studies, with 56 subjects who had ovarian tumors, who had the inclusion and exclusion criteria research, in Department of Obstetrics and Gynecology FK-Unair/dr. Soetomo Hospital, Surabaya. After that, patients performed surgery, and histopatology examination of operation specimens in this hospital. Inclusion criteria for this study were patients with epithelial ovarian tumors from Anatomical Pathology examination. The 56 study subjects , we were divided into 2 groups based on histopatological examination, one group with 31 subjects we classified into epithelial type malignant ovarian tumors study group, while the other group consist of 25 subjects we classified into epithelial type benign ovarian tumors study group.Sensitivity, specificity, positive predictive value, negative predictive value of CA125 was 87.1%; 28%; 60%; and 63.8%. Sensitivity, specificity, positive predictive value, negative predictive value LPA was 51.6%; 76%; 72.7%; and 55,9%. And sensitivity, specificity, positive predictive value, negative predictive value combination LPA - CA125 was 45.2%; 92%; 87.5%; and 57.5%. And in this study we get the CA125 cut-off at 50 u/mL gives better results than 35 u/mL, whereas the LPA cut-off 2.5 ?M still the best, although the Kappa analysis results for both are not significant.In this study, plasma LPA level patients with ovarian tumor can not be used as a tumor marker for epithelial malignant ovarian cancer. CA125 levels can be used as a tumor marker for epithelial malignant ovarian cancer, while combination of CA125 levels and LPA levels increase the specificity but does not increase the sensitivity. This was contrast with previous studies that the sensitivity and specificity of plasma LPA is excellent and they proposed use LPA plasma as a tumor marker.
Haruskah Plasenta Perkreta disertai Lakuna Bizarre? Yusuf, Dwiyanarsi; Khonsa, Oni; Apriliawan, Tri; Lisnawati, Yuyun
Majalah Kedokteran Indonesia Vol 69 No 8 (2019): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.69.8-2019-189

Abstract

Background: Placenta percreta is a life-threatening condition that requires multidisciplinary management. The incidence of placenta percreta increases with increasing incidence of cesarean section. Antenatal diagnosis is an important point to prevent morbidity and mortality in both mother and baby. Ultrasonography (USG) is one of the relatively cheaper and easier modalities for diagnosing placenta percreta. Objective: To identify the optimal ultrasonographic criteria for the diagnosis of placenta percreta.Methods: We followed 2 cases, which performed antenatal care (ANC). Both patients then performed an ultrasound examination according to the placenta accrete index (PAI) method. The ultrasound assessment findings are then compared with intraoperative clinical findings and histological features. Results: From two cases, we did not find any Bizarre lacuna, but a thin retroplacental myometrial layer was found accompanied by loss of clear zone. The findings on ultrasonography are in accordance with intraoperative findings and histological features, where the appearance of the placenta percreta is clearly visible.Conclusion: It is different from the assessment of PAI, where the presence of lacuna is the biggest predictive factor for placenta adhesiva, in both cases, a thin myometrial layer of retroplacenta accompanied by a clear clear zone, although no lacuna was found, sufficiently describe the placenta percreta
Karakteristik Klinik dan Analisis Faktor Risiko yang Berperan pada Derajat Keparahan Invasi Plasenta Abnormal di RSUP Persahabatan pada Tahun 2015-2018 Feharsal, Yuri; Lisnawati, Yuyun; Pudyastuti, Sri; Khonsa, Oni; Apriliawan, Tri; Botefilia, Botefilia; Nurfauziah, Nadia; Agustin, Kindy
Majalah Kedokteran Indonesia Vol 69 No 6 (2019): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.69.6-2019-195

Abstract

Background: Morbidly adherent placenta is a condition which placenta adheres and invades deeply into the myometrium and, in some cases, until uterine serosa, thus contribute to peri-partum hemorrhage and significant maternal mortality.Purpose: To identify prevalence, clinical characteristics and their odds ratio to increasing se-verity of morbidly adherent placenta case in RSUP Persahabatan from 2015 to 2018.Methods: Cohort retrospective study.Results: From 2015 to 2018, prevalence of morbidly adherent placenta was around 0.8%. The risk factors which contribute to increasing severity of morbidly adherent placenta were: age above 35 years (OR 1.6, 95% CI 0.41-6.24) and history of Caesarean section more than 2 times (OR 1.63, 95% CI 0.41-6.46). The presence of increasing severity of morbidly adherent placenta were related to volume of blood loss more than 1000 ml during surgery (OR 2.13, 95% CI 0.52-8.76). Conclusion: The prevalence of morbidly adherent placenta at Persahabatan General Hospital in 2015-2018 was 0.8%. Age, history of Caesarean section more than 2 times, volume of blood loss, and duration of surgery were not statistically associated with adherent placenta case.
Co-Authors Agustin, Kindy Askandar Tjokroprawiro Botefilia, Botefilia Khonsa, Oni Lisnawati, Yuyun Nurfauziah, Nadia Sri Pudyastuti Yuri Feharsal Yusuf, Dwiyanarsi