This research is about operational audit of medical inventory management at Dedy Jaya Hospital Brebes aimed to assess the effectiveness of the  medical inventory management, indentified weaknesses, gave recommendation and improve medical inventory management in pharmacy installation Dedy Jaya hospital Brebes. The research method used qualitative descriptive research methods. The research data is conducted by field studies through interview, observations and documentations. The analysis of data that used in the research was the qualitative analysis methods. The scope of research is focused on inventory management only as a medicine that includes 24 hour pharmacy service, planning, procurement and reception supplies pharmateuical, medicine storage, management of medicine expiration, the officer who reviewed medicine orders, waiting time, pharmaceutical supplies provisioning request from room service to the warehouse, distribution from warehouse to service unit and other units. Based on the results of the research note that medical inventory management at Dedy Jaya Hospital Brebes has been running effectively because all aspect of management of medical supllies have been conducted in accordance with existing regulations but there are still some flaws that can weaken the operational activities of the company itself. Medical inventory management  at Dedy Jaya Hospital Brebes is already running in accordance with existing policy. Based on the results of the audit finding over weakness of medical inventory management at Dedy Jaya Hotel, researchers provide recommendations and improvements that can be made as consideration so that the company can be more effective in carrying out its operational activities in particular for medical inventory management.  Keywords : Operational Audit, Effectiveness, Inventory, and Management