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Nyoman Suci W, Nyoman Suci
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Pengaruh suplementasi spirulina terhadap beberapa parameter sindrom metabolik (studi di puskesmas lebdosari kota semarang) Sakti, Mayta; SS, Darmono; W, Nyoman Suci
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 3, No 2 (2015)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (447.583 KB) | DOI: 10.14710/jgi.3.2.94-100

Abstract

Latar belakang : Sindrom metabolik adalah kumpulan kelainan metabolik lipid maupun non-lipid yang merupakan faktor risiko penyakit kardiovaskuler, meliputi obesitas sentral, dislipidemia, hipertensi, dan hiperglikemia kronis. Spirulina mengandung beberapa bahan aktif terutama phycocyanin dan β karoten yang memiliki aktivitas antioksidan dan antiinflamasi. Suplementasi spirulina mempunyai aktivitas biologis seperti mencegah penyakit akibat perlemakan hati, menurunkan kadar glukosa darah, profil lipid, serta menurunkan tekanan darah.Tujuan : Menganalisis pengaruh suplementasi spirulina terhadap beberapa parameter sindrom metabolik meliputi tekanan darah (TD), kadar glukosa darah puasa (GDP), kadar trigliserida (TG), dan kadar kolesterol HDL.Metode : Desain penelitian ini adalah quasi experimental dengan control group design. Subjek sejumlah 39 pasien dibagi menjadi kelompok kontrol (n=19) dan kelompok perlakuan (n=20) secara acak. Intervensi berupa suplementasi spirulina sebanyak 3 gram selama 4 minggu. Kadar GDP, kadar TG, kadar kolesterol HDL, dan TD diukur sebelum dan sesudah intervensi. Hasil : Kadar GDP pada kelompok kontrol menurun secara signifikan (p=0.000), tetapi tidak ada perubahan pada TD, kadar TG, dan kadar kolesterol HDL. Kadar GDP (p=0,005), TG (p=0.040), dan TD sistolik (p=0.010) menurun secara signifikan tetapi perubahan kadar kolesterol HDL (p=0,970) dan TD diastolik (p=0,655) tidak signifikan pada kelompok perlakuan.Simpulan : Suplementasi spirulina selama 4 minggu menurunkan kadar glukosa darah, kadar TG, serta TD sistolik. Namun, tidak berpengaruh pada kadar kolesterol HDL dan TD diastolik.
Pengaruh pemberian rumput laut sargassum sp terhadap kadar hemoglobin dan feritin serum Yuniarti, Anita; Hadisaputro, Soeharyo; W, Nyoman Suci
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 5, No 1 (2016)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.139 KB) | DOI: 10.14710/jgi.5.1.7-13

Abstract

Background : Anemia is a global phenomenon involving developing countries. Fifty percent of anemia cases is caused by iron deficiency. Indonesia is a tropical country that is rich in various kinds of marine plants and still not used optimally.Sargassum sp is one of high iron contains seaweed but still less utilized. Objectives: the aim of this study was to analyze the influence of Sargassum sp on hemoglobin and serum ferritin level. Methods : a simple randomized with pre and posttest control group design was used in this study. Sixteen Wistar male rats were divided into 2 groups (1) control (2) treatment and fed with Sargassum sp 0,49 g for 14 days. During the treatment pre and post hemoglobin and serum ferritin was measured. Results : : iron level in Sargassum sp was 122,37mg/g and Pb level was 0,00009%. In the treatment group hemoglobin level was significantly increased 5,24 mg/dl (p<0,05) and serum ferritin was increased 4,20 µg/ml (p>0,05). Conclusion : sargassum sp increased hemoglobin level on anemic wistar rat but not in serum ferritin significantly. 
Pengaruh pemberian jus mangga terhadap profil lipid dan malondialdehyde pada tikus yang diberi minyak jelantah Zaki, Ibnu; Johan, Andrew; W, Nyoman Suci
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 3, No 2 (2015)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.212 KB) | DOI: 10.14710/jgi.3.2.108-115

Abstract

Latar belakang : Pemberian minyak jelantah menyebabkan peningkatan profil lipid (kolesterol total, trigliserida, kolesterol LDL) dan Malondialdehyde(MDA) darah serta menurunkan kolesterol HDL. Jus mangga mengandung serat, vitamin C, E dan betakaroten yang berpotensi memperbaiki profil lipid dan menurunkan MDA.Tujuan :menganalisis pengaruh jus mangga terhadap profil lipid dan MDA tikus yang diberi minyak jelantah.Metode : Penelitian eksperimental dengan randomized controlled pre-post test design. Tikus Sprague Dawley di bagi acak menjadi tiga kelompok yaitu kelompok K diberi Aquades, kelompok P1 diberi minyak jelantah, dan kelompok P2 diberi minyak jelantah, jus mangga). Pemberian jus mangga diberikan 1x/hari peroral selama 14 hari. Kolesterol total, LDL, HDL diukur dengan metoda CHOD-PAP. Kadar Trigliserida diukur dengan metoda GPO-PAP. Analisis kadar MDA darah dengan metoda TBARS.Hasil : Terjadi peningkatan kolesterol total, trigliserida, LDL dan MDA serta penururnan HDLdarah setelah pemberian minyak jelantah. Pemberian jus mangga secara bermakna menurunkan kolesterol total, trigliserida, LDL dan MDA darah serta meningkatkan HDL. Rerata perubahan setelah pemberian jus mangga pada P2 kolesterol total -72,90±9,33 mg/dl,trigliserida -39,29±8,13 mg/dl, LDL -8,71±3,05mg/dldan MDA -4,25±0,52. Rerata Peningkatan HDL 13,70±4,16 mg/dl.Simpulan : Pemberian jus mangga menurunkan kolesterol total, trigliserida, LDL, MDA dan meningkatkan HDL.
Pengaruh suplementasi seng dan vitamin B6 terhadap kadar hemoglobin, hematokrit dan indeks eritrosit pasien malaria vivax yang anemia Sofiyetti, Sofiyetti; Dharmana, Edi; Rahfiludin, M. Zen; W, Nyoman Suci; Afifah, Diana Nur
Jurnal Gizi Indonesia (The Indonesian Journal of Nutrition) Vol 5, No 1 (2016)
Publisher : Department of Nutrition Science, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (509.713 KB) | DOI: 10.14710/jgi.5.1.20-25

Abstract

Background: Zinc supplementation decrease the risk of malaria parasitaemia, increasing ferritin serum level and hemoglobin in patients with malaria. Zinc influence the activity of aminolevulinic acid dehydratase (ALAD) an enzymes that catalizes heme synthesize. Vitamin B6 in pyridoxal 5-phosphate (PLP) from has a role in alpha-aminolevulinic acid (ALA) formation, which is the precursor of heme in hemoglobin. PLP also inhibit the growth of the malaria parasite.Objective: The objective was to analyze the effect of zinc and vitamin B6 supplementation on hemoglobin level, hematocrit and erythrocyte indexs (MCV, MCH and MCHC) of anemic Plasmodium vivax malaria patients.Methods: Double Blind Randomised Controlled Trial with pre and post test design. 30 subjects were divided into two groups: the suplementation group were given zinc 1x10 mg/day with vitamin B6 1x5 mg/day and the control group were given a placebo for 30 days. Data analysis by paired t-test, independent t-test and Mann Whitney.Results: There was an increase in Hb levels in the suplementation group (p=0.0001), the control group (p=0.001) and there was a significant difference on the increase between the two groups (p=0.020). Hematocrit significant increase only in the suplementation group (p=0.0001). There were no differences on erythrocyte index parameter in both groups.Conclusion: Zinc and vitamin B6 supplementation of for 30 days increase the hemoglobin level, hematocrit and there were no effect on erythrocyte indexs of anemic Plasmodium vivax malaria patients.
Co-Authors Andrew Johan Darmono SS Diana Nur Afifah, Diana Nur Edi Dharmana Mayta Sakti, Mayta Mohammad Zen Rahfiludin Soeharyo Hadisaputro Sofiyetti, Sofiyetti Yuniarti, Anita Zaki, Ibnu