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All Journal Indonesian Archives of Biomedical Research (InABR)
Maftuhatun Fista Amalia
Master’s Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta 10430, Indonesia
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Does Cytoglobin Play a Role as Anti-Fibrosis? Maftuhatun Fista Amalia; Sri Widia A. Jusman
Indonesian Archives and Biomedical Sciences Vol 2 No 1 (2022): Indonesian Archives of Biomedical Research (InABR) 2(1): 2022
Publisher : Konsorsium Ilmu Biomedik Indonesia (KIBI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55392/indarcbiores.v2i1.25

Abstract

Cytoglobin (Cygb) is a vertebrate globin protein that is synthesized by fibroblasts and expressed in a variety of organs. Cygb’s function is not fully understood. In contrast, activated fibroblasts (myofibroblasts) are known to produce collagen, which is the major component of the extracellular matrix (ECM) and contributes to abnormal wound healing. There are three phases in wound healing: (1) injury; (2) inflammation; and (3) tissue regeneration. Myofibroblasts will apoptosis throughout the healing phase. If myofibroblasts fail to undergo apoptosis, this might end in fibrosis. This condition induces relative hypoxia in fibrosis. Several investigations have found that overexpression of Cygb serves as an antifibrosis agent by reducing collagen production. The potential involvement of Cygb in avoiding fibrosis in diverse tissues is discussed in this article.  Keywords: Cytoglobin (Cygb), wound healing, anti-fibrosis, collagen
Co-Authors Sri Widia A. Jusman