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Dwi Retnoningrum
Department of Clinical Pathology, Faculty of Medicine, Universitas Diponegoro
Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology

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Correlation between Interleukin-17 Levels with C-Reactive Protein and Neutrophil Lymphocyte Ratio in Sepsis Dwi Retnoningrum; Muchlis Achsan Udji Sofro; Setyo Gundi Pramudo; Satrio Adi Wicaksono; Andaru Dahesihdewi
Journal of Biomedicine and Translational Research Vol 8, No 2 (2022): August 2022
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v8i2.15323

Abstract

Background: Sepsis is a condition in systemic infection associated with organdysfunction. Interleukin-17 is a pro-inflammatory cytokine produced by Th-17 cells. C-reactive protein and neutrophil-lymphocyte ratio (NLR) have been widely used asmarkers of inflammation. The relationship between IL-17 as a proinflammatorycytokine with CRP and NLR has not been reported.Objective: This study aims to prove the correlation between IL-17 with CRP and NLRin septic patients.Methods: Analytical observational study with a cross-sectional approach was carriedout on 40 septic patients in July–December 2020. IL-17 levels were obtained by theELISA method while CRP levels were obtained using the immunoturbidimetric method.NLR was the result of dividing the absolute number of neutrophils and lymphocytesfrom the automatic hematology analyzer. Correlation between variables was performedusing Spearman correlation test.Results: The median levels of IL-17, CPR, and NLR were 363.55 (11.4-1695.80)pg/mL, 13.25 (0.43-53.87) mg/L, and 12.00 (2.26–48.5), respectively. The Spearmancorrelation test between IL-17 levels and CRP obtained p = 0.019, r = 0.37, and NLR p= 0.425, r = 0.13.Conclusion: There is a weak positive correlation between IL-17 levels and CRP inseptic patients. There is no correlation between IL-17 levels and NLR in septic patients.
Renoprotective Effect Of Sambiloto (Andrographis Paniculata) Leaf Extract On Lipopolysaccharide – Induced Septic Rats Adhika Bastian Bagas Prananta; Nyoman Suci Widyastiti; Ariosta Ariosta; Dwi Retnoningrum; Rezya Salsabela; Vega Karlowee; Neni Susilaningsih
Journal of Biomedicine and Translational Research Vol 9, No 1 (2023): April 2023
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v9i1.17286

Abstract

Background: Associated with sepsis is the illness known as acute kidney injury (AKI). AKI may be mediated by uric acid, and blood creatinine levels can be utilized to diagnose the condition to measure kidney function. Sambiloto (Andrographis paniculata) is a traditional medicine that has flavonoid compounds that can reduce creatinine levels and Xanthine Oxidase Inhibitors which can reduce uric acid levels.Objective: Septic model rats generated by lipopolysaccharide were used to test the effects of sambiloto (Andrographis paniculata) leaf extract on serum creatinine and uric acid levels (LPS).Methods: This study was experimental employing 25 rats split into 5 groups as the post-test alone control group: healthy control with standard feed (HC), negative control with LPS injection(NC), Treatment (T)1 (A.Paniculata 200 mg/kgBW+LPS), T2(A.paniculata 400 mg/kgBW+LPS), and T3(A.paniculata 500mg/kgBW+ LPS). A.paniculata leaf extract was given via oral gavage on day 8-21. Intraperitoneal injection of LPS 5 mg/kgBW was given on day 22. On the 25th day, the blood serum was analyzed for creatinine levels using Jaffe method and uric acid was analyzed using the enzymatic photometric method. One-way analysis of variance (Kruskal-Wallis) and the Kruskal-Wallis test were used to evaluate the data.Results: The mean creatinine levels of HC,NC,T1,T2,T3 were 0.7±0.01;3.5±0.04;2.9±0.03;1.9±0.05; 1.3 ±0.04 mg/dl respectively. The mean uric acid levels of HC.NC.T1.T2.T3 were 1.7±0.05;8.2±0.11; 4.5±0.03;4.0±0.12;3.0±0.19 mg/dl respectively. There were significant differences (p<0.05) in creatinine levels in groups T2(p=0.031) and T3(p=0.001) to NC group and serum uric acid levels in groups T1(p<0.001), T2(p<0.001), and T3(p<0.001) to NC group which creatinine and uric acid levels were lower than NC group.Conclusion: Andrographis paniculata leaf extract has renoprotective effect against AKI in LPS-induced septic ratsKeywords: Andrographis paniculata, creatinine, uric acid, lipopolysaccharide, AKI, sepsis
Co-Authors Adhika Bastian Bagas Prananta Ariosta Ariosta MARIA BINTANG Muchlis Achsan Udji Sofro Neni Susilaningsih Nyoman Suci Widyastiti Rezya Salsabela Satrio Adi Wicaksono Setyo Gundi Pramudo Vega Karlowee