Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Jurnal Ilmiah Farmasi EKSAKTA: Journal of Sciences and Data Analysis INDONESIAN JOURNAL OF PHARMACY Science and Technology Indonesia Jurnal Farmasi Sains dan Komunitas Majalah Farmaseutik Jurnal Ilmiah Manuntung JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Aris Perdana Kusuma, Aris Perdana
Department Of Pharmacy, Universitas Islam Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Earth & Planetary Sciences Environmental Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

Published : 11 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 11 Documents
Search

 1   2 
FORMULASI TABLET EKSTRAK ANGKAK (RED YEAST RICE) DENGAN VARIASI CROSCARMELLOSE SODIUM SEBAGAI PENGHANCUR DAN LAKTOSA SEBAGAI PENGISI Resti, Adestria; Kusuma, Aris Perdana; Fudholi, Achmad
Jurnal Ilmiah Manuntung Vol 3 No 1 (2017): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung akademi farmasi samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (180.856 KB) | DOI: 10.51352/jim.v3i1.95

Abstract

Angkak or better known as Red yeast rice is fermentation rice using a mold Monascus purpureus. Some studies of red yeast rice can lower cholesterol levels in the body because it contains monoakolin K or similliar with lovastatin compound. Generally in community consumption of red yeast rice only with pour in the boilling water so it can causing inconvenience for its customers. This study aims to make a formulation tablet of red yeast rice extract which varied with the levels of croscarmellose sodium 5% -1% (32mg, 26mg, 19,5mg, 13mg, 6,5mg) and lactose (75,75mg, 82.25 mg, 88,75mg , 95,25mg, 101,75mg) in order to get a best physical properties of the tablet including friability and disintegration time. Angkak extract was made by remaseration method using ethanol 75% and the manufacture of tablets using wet granulation method. Stastical test tablet extract angkak using One Way ANOVA with 95% confidence level. Optimum formula obtained by using the Simplex Lattice Design (SLD) using Design Expert version 8.0.7.1 program and statistically tested using one-sample t-test. The results from test showed the proportion of croscarmellose sodium 6.5mg and 101.75mg lactose produces tablets with the best of physical properties of red yeast rice extract.The result is indicate that the combination of croscarmellose sodium and lactose may affect response the physical properties of red yeast rice extract tablets.
Formulation and Evaluation of Kaptopril Tablets Using Threaded Amylum Tubes and HPMC as Fillers and Binders of the Direct Method Ahmad Sastra Kelana; Aris Perdana Kusuma; Oktavia Indrati
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 18, ISSUE 1, February 2018
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/eksakta.vol18.iss1.art2

Abstract

Indonesia is a tropical country which has many potential plants as excipients, likestarches and tubers. Amylum of taro tuber (Colocasia esculenta) has the potential to be developed into excipient but its use is limited. The purpose of this study was to optimize the formulation and to evaluate the characteristics of captopril tablets by using amylum of taro tuber and HPMC modified as filler and binder on direct compression method. Amylum of taro tuber was obtained by extraction process, then combined with HPMC by partial pregelatination and co-process method. Variation of the starch was divided into five formulation. The main test included friability test, hardness test, dissolution test, and assay. The data analysis was done by theoretical approach between the evaluation result and the literature to observe the result of the modification formulation. It indicated that the combination of equal amount of taro amylum and microcrystalline cellulose (MCC) pH 102 (50% : 50%) has the best result among others. Friability percentage was 0.17 ± 0.07%, disintegration time was 12.09 ± 0.52 minutes, assay was 97.88 ± 1.71% and dissolution test results was 90.65 ± 4.81%.
Effervescent Tablet Formulation Melinjo Seed Extract (Gnetum gnemon L.) Using PEG 6000 As Lubricant and Citric Acid - Tartaric Acids As Acid Sources Puput Andi Apsari; Dewi Nur Eka Sari; Aris Perdana Kusuma; Oktavia Indrati
EKSAKTA: Journal of Sciences and Data Analysis VOLUME 18, ISSUE 1, February 2018
Publisher : Fakultas Matematika dan Ilmu Pengetahuan Alam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/Eksakta.vol18.iss1.art4

Abstract

Melinjo seeds (Gnetum gnemon L.) have antioxidant properties one of which is from phenol compounds. However, there is no pharmaceutical dosage form of melinjo seeds especially effervescent tablet. The purpose of this research was to determine the best variation of citric-tartaric acid and PEG 6000 from effervescent tablet of melinjo seed extract. The effervescent tablet of melinjo seed extract were formulated with variation of citric-tartaric acid 25%:75%, 65%:35%, 50%:50%, 20%:80% and PEG 6000 0%, 2%, 3%, up to 5%. The effervescent tablet were made by melting parts of acids and bases, added with extract and other ingredients. The evaluation included flow and powder tapping, tablet hardness, weight variation, friability, and tablet solubility test. The data were analyzed by comparing approaches based on the requirements of Pharmacopeia Indonesia V andUnited States of Pharmacopeia 36.Variations of equal amount of citric-tartaric acid produced hard effervescent tablets with small friability. The unbalanced acid concentration resulted in higher friability. The greater the concentration of citric acid resulted in the longer solubility of the tablet. The addition of PEG 6000 made the flow time of granules quicker, while higher concentrations would increase the hardness of tablets and accelerate the soluble time. Excessively high concentrations resulted in a high degree of friability. Variation of citric-tartaric acid and PEG 6000 influenced physical properties of granule and effervescent tablet extract of melinjo seeds, such as flowability, hardness, friability, and solubility of the tablet.
PREPERATION AND CHARACTERIZATION OF β-CYCLODEXTRIN INCLUSION COMPLEXES ORAL TABLETS CONTAINING POORLY WATER SOLUBLE GLIMIPIRIDE USING FREEZE DRYING METHOD Yandi Syukri; Laryssa Fernenda; Fissy Rizki Utami; Isna Qiftayati; Aris Perdana Kusuma; Rochmy Istikaharah
Indonesian Journal of Pharmacy Vol 26 No 2, 2015
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (793.45 KB) | DOI: 10.14499/indonesianjpharm26iss2pp71

Abstract

Glimepiride is an oral antidiabetic drugs which is practically insoluble in water. The formation of β-cyclodextrin inclusion complex was able to increase the solubility of glimepiride. This study aim to prepare, characterize and formulation of inclusion complex tablets in order to meet the requirement in Pharmacopeia. The inclusion complex were prepared in a molar ratio of 1:1 and 1:2 by freeze drying method, afterthat  characterized include FTIR spectroscopy and scanning electro microscope (SEM). Further, it was formulated into tablets by direct compression technique using primogel and crospovidone as superdisintegrants. The tablets were evaluated include weight uniformity, hardness, friability, disintegration, and dissolution. The dissolution studies of inclusion complex were performed by using USP II apparatus.  The result of FTIR and SEM provided evidence of the formation of complexes after utilizing freeze-drying methods. The tablet evaluation containing inclusion complex glimepiride-β cyclodextrin with primogel and cropovidone as disintegrant showed that increased concentration of disintegrant will increase disintegration time of the tablets. All of formulas meet the requirements in the Pharmacopoeia. The inclusion complex of glimepiride–β cyclodextrin successfully used for enhancing the solubility of glimepiride and the tablets meet the requirement in Pharmacopeia.Keywords: Glimepirid, β-cyclodextrin, primogel, crospovidone
Flexibility of Custom Design over Simplex Lattice Design in Co-Processed Excipient Formulations Aris Perdana Kusuma
Science and Technology Indonesia Vol. 3 No. 1 (2018): January
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (281.126 KB) | DOI: 10.26554/sti.2018.3.1.30-34

Abstract

Custom design is a modeling technique that puts forward the custom formula on the pharmaceutical formula optimization. The components may be adjusted to the formula constraints. However, these designs sometimes do not accommodate all the components used. In addition, its effectiveness is not necessarily optimal when compared with standard designs such as simplex lattice design (SLD). This study used microcrystalline cellulose PH 101 (MCC PH 101), lactose and K30 kollidon which were computerized. Custom design and SLD compared with Design Expert software based on previous research data. Tablet hardness and tapping index were used as test parameters to assess design effectiveness. The optimal formula result obtained was MCC PH 101: lactose: kollidon K30 80% each: 10%: 10% for SLD. This value differs from custom designs that get results in the absence of lactose proportions. Custom design prediction results actually get better value than SLD for tablet hardness and tapping index.
FORMULATION OF CHLORPHENIRAMINE MALEATE TABLETS USING CO-PROCESSED EXCIPIENT AS A FILLER AND BINDER Yandi Syukri; Romdhonah Romdhonah; Anisa Nur Fazzri; Rio Fandi Sholehuddin; Aris Perdana Kusuma
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 16, No 1 (2019)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (465.142 KB) | DOI: 10.24071/jpsc.001717

Abstract

Co-Processed Excipient (CPE) is technological innovation for tablet preparation through the direct compression method with a quick and straight forward manufacturing process because it improves the compressibility and flowability. This research aimed to formulate and evaluate of chlorpheniramine maleate tablets using spray dried CPE as filler and binder. The spray dried CPE containing MCC PH 101, and Kollidon K30 was made into tablets through a direct compression method. Meanwhile, Ludipress and Avicel PH 102 were used as filler-binder comparators. All the prepared tablet formulations were then evaluated for weight variation, hardness, friability, disintegration time, content uniformity of active ingredient, and dissolution test. The physical properties of tablets with CPE as a filler and binder produced an average weight of 151.65 1.53 mg, 5.92 0.38 kg of hardness, 0.06 0.051% friability, 520.00 2.00 seconds of disintegration time, and 99.24 0.15% content uniformity of active ingredient. The comparators indicated better disintegration time than CPE (p0.05), while the dissolution test showed that more than 80% (Q) of the amount of active ingredient was dissolved in 30 minutes. CPE could be successfully used to prepare tablet dosage form, and the tablets had fulfilled the standards of pharmacopoeia.
PENGARUH SODIUM STARCH GLYCOLATE (SSG) SEBAGAI PEMBAWA TERHADAP PENINGKATAN DISOLUSI IBUPROFEN MENGGUNAKAN METODE FREEZE DRYING Riyan Hariyadi; Teuku Nanda Saifullah Sulaiman; Aris Perdana Kusuma
Majalah Farmaseutik Vol 8, No 2 (2012)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (581.513 KB) | DOI: 10.22146/farmaseutik.v8i2.24071

Abstract

Ibuprofen merupakan obat analgetika antipiretik dan anti inflamasi yang mempunyai kelarutan praktis tidak larut dalam air dan termasuk dalam BCS KELAS II. Salah satu pendekatan yang digunakan untuk meningkatkan kelarutan adalah menggunakan teknik dispersi padat. Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh SSG terhadap peningkatan disolusi ibuprofen menggunakan metode freeze drying. Metode yang digunakan yaitu dispersi padat dengan pembawa sodium starch glycolate menggunakan metode freeze drying. Variasi kadar Ibuprofen:sodium starch glycolate yang digunakan yaitu 1:0 (kontrol); 1:1(F1); 1:2 (F2); 1:3 (F3); 1:4 (F4). Peningkatan disolusi ibuprofen dianalisis menggunakan profil disolusi dan Q60. Data yang diperoleh dari uji disolusi dianalisis dengan pendekatan secara teoritis dan statistik menggunakan one way ANOVA kemudian dilanjutkan t-test dengan taraf kepercayaan 95%. Berdasar foto morfologi SEM, dispersi padat ibuprofen-SSG (F2) metode freeze drying menunjukkan bentuk yang amorf. Adanya interaksi antara ibuprofen dengan SSG terlihat dari pergeseran pita kromatogram. Dispersi padat formula II mengalami penurunan nilai entalpi dengan nilai 37,79 J/g pada termogram DSC. Dispersi padat ibuprofen-SSG (F2) metode freeze drying menunjukkan profil disolusi yang tinggi dibandingkan dengan campuran fisik dan ibuprofen tunggal. Perbandingan ibuprofen-SSG dengan profil disolusi paling tinggi yaitu 1:2 dengan nilai Q60 64,81 ±1,42%.
Formulation peel-off gel mask of Impatiens balsamina l. as an antibactery against Staphylococcus aureus Fitriani Mahyun; Aris Perdana Kusuma; Hady Anshory
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 3, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jkki.vol9.iss3.art6

Abstract

Background: Acne is a skin disorder characterised by inflammation, accompanied by a blockage of the oil glands in the skin. One of the causes of acne is Staphylococcus aureus bacteria. Many plants have been widely studied as an antibacterial agent, including Garden Balsam Leaf (Impatiens balsamina L.) which could be formulated in a peel-off gel preparation.Objective : The purpose of this research was formulating an antibacterial peel-off gel mask with a variation of viscosity enhancing agent hydroxypropyl methylcellulose (HPMC), as well as testing its antibacterial activity on Staphylococcus aureus.Methods : HPMC 1-2% was formulated in peel-off gel mask of Garden Balsam leaf extract. Physical properties such as viscosity, pH, spreadability, and drying time were tested, while antibacterial activity test was conducted by the agar-diffusion method.Results : The viscosity of the entire formula was > 20,000 cP, pH 6, drying time > 20 minutes, and spreading power > 6 cm. Also, the peel-off gel mask also showed antibacterial activity on Staphylococcus aureus with average inhibition zone were > 10 mm, which indicated strong antibacterial inhibitory power.Conclussion : The concentration variation of HPMC had a significant effect on all physical properties test. HPMC 1.5% in the preparation showed the most optimum results.
Characterization, formulation and evaluation of glibenclamide with ß-cyclodextrin inclusion complexes tablets Yandi Syukri; Farida Ulfa; Asih Lestari; Lelita Ayu Saputri; Rochmy Istikharah; Aris Perdana Kusuma
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 3, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss3.art3

Abstract

Background: Glibenclamide is an oral antidiabetic drug which is practically insoluble in water. Formation of ß-cyclodextrin inclusion complex was able to increase glibenclamide solubility. Objective: Aims of this study are to characterize, formulate and evaluate  inclusion complex tablets of glibenclamide to meet the requirements in Pharmacopeia.Methods: Inclusion complex was prepared in a 1: 1 and 1: 2 molar ratio  by spray drying method. Characterization were performed by using Fourier Transform Infrared (FTIR) spectroscopy and Scanning Electron Microscope (SEM). Further, it was formulated into tablets by direct compression technique using primojel and crospovidone as disintegrants.   Uniformity weight, hardness, friability, disintegration, and tablets were evaluated include dissolution. Dissolution studies of inclusion complex were performed by using United States Pharmacopeia (USP) II apparatus.  Drug concentration dissolution was determined with high pressure liquid chromatography (HPLC).Results: Result of FTIR and SEM provided evidence of  glibenclamide and ß-cyclodextrin complex formation after using spray drying methods. The tablet evaluation with primojel and crospovidone as disintegrant showed that increase concentration of disintegrant would increase disintegration time of the tablets. All of the formulas meet the requirements in the Pharmacopoeia.Conclusion: The inclusion complex of glibenclamide–ß cyclodextrin successfully used for enhancing the solubility of glibenclamide. The tablets meet the requirements in Pharmacopeia.
The role of pharmacists at the implementation of transformational leadership in the hospital central sterilization Nugroho, Dwi Agung Nugroho; Kusuma, Aris Perdana
Jurnal Ilmiah Farmasi Vol. 20 No. 2 (2024): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol20.iss2.art8

Abstract

Background: Pharmacists in hospitals have a role that is not only limited to the pharmacy installation and management but also contributes to the Central Sterile Supply Department (CSSD) installation. The issue of sterilization and cleanliness of instruments and linen in hospitals is the responsibility of the CSSD to support the sustainability of quality services in hospitals. Although related to sterility, most of the staff of the installation CSSD in Indonesia are high school graduates with minimal health knowledge and are often transferred from other installations due to problems. Some hospitals combine CSSD with laundry; in contrast to the pharmacy installation, which actively involves pharmacists and pharmaceutical technical personnel, compliance with regulations and provisions is more highly respected compared to personnel in the CSSD installation.Objective: This study aims to analyze the application of transformational leadership style in CSSD installation in hospitals while highlighting the lack of leadership studies in pharmacy and the effectiveness of leadership in managing installation performance in hospitals with non-health personnel.Methods: The methods used include direct observation, interviews, and questionnaires with samples consisting of installation leaders and staff CSSD in hospitals. We explore the factors influencing and challenges faced in implementing transformational leadership in a hospital CSSD environment.Results: The questionnaire results showed that the transformational leadership scores of the leaders were high, and most employees were satisfied with the implementation of transformational leadership. Some management concepts have been applied to improve performance, but many have not been able to provide change due to a lack of response from employees.Conclusion: A leader in CSSD installation must be flexible in adopting a leadership style that suits the situation and conditions; the application of leadership style must consider internal factors such as human resources quality and organizational structure as well as external factors that are hospital management and budget support.
Co-Authors Achmad Fudholi Ahmad Sastra Kelana Anisa Nur Fazzri Asih Lestari Dewi Nur Eka Sari Farida Ulfa Fissy Rizki Utami Fitriani Mahyun Hady Anshory Ifa Nurazizah Isna Qiftayati Laryssa Fernenda Lelita Ayu Saputri Nugroho, Dwi Agung Nugroho Oktavia Indrati, Oktavia Puput Andi Apsari Resti, Adestria Resti, Adestria Rio Fandi Sholehuddin Riyan Hariyadi Rochmy Istikaharah Rochmy Istikharah Romdhonah Romdhonah Suparmi Teuku Nanda Saifullah Sulaiman Yandi Syukri