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All Journal Jurnal Kedokteran Brawijaya JPKMI (Jurnal Pengabdian Kepada Masyarakat Indonesia) Sanus Medical Journal
Irena Ujianti
Departemen Fisiologi, Fakultas Kedokteran, Universitas Muhammadiyah Prof. DR. HAMKA, Tangerang, Indonesia
Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : Sanus Medical Journal

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Pengaruh Pemberian Diet Restriksi Vitamin B12 Pada Tikus: Kajian Insulin dan Glukosa Plasma Imelda Rosalyn; Dewi Irawati SS; Irena Ujianti; Patwa Amani
Sanus Medical Journal Vol. 2 No. 1 (2021): Vol. 2 No. 1 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.5431

Abstract

Background: Deficiency of vitamin B12 remains a health problem in both developed and developing countries. Many journal studies showed an association between deficiency of vitamin B12 and metabolic disorder, one of which is insulin resistance, one of the most significant metabolic diseases. Resistance to insulin may be assessed by changes in plasma glucose and insulin levels. This study explored a possible relationship between vitamin B12 restriction and glucose metabolism. Materials and Methods: This study used an experimental method of 18 male Sprague Dawley rats (Rattus norvegicus, 300-400 gram, age 7-8 months), divided into three groups: control (G1), four weeks treatment group (G2 ) and 12-week treatment group (G3). In the control group, regular feed, the standard diet was given, while the treatment group was assigned vitamin B12, AIN-93M deficiency feed according to the treatment age. Results: Plasma glucose increased in treatment group after 4 weeks (control vs P1= 104.7 ± 5.04 vs 206.8 ± 4.5 p = 0.000) and 12 weeks (control vs P3 = 99.9±6.3 vs 144.7±6.8 p<0.01). Plasma insulin decreased in treatment group after 4 weeks (control vs P1=63.8 ± 1.5 vs 59.9 ± 0.7 p > 0.05) and 12 weeks (control vs P3 = 61.5±0.64 vs 57.4±1 p>0.05). Conclusion: Increased homocysteine deficiency due to dietary vitamin B12 can cause insulin resistance syndrome. As a result, glucose and plasma insulin levels are disrupted Keywords: Homocysteine, vitamin B12 Deficiency, Glucose, Insulin, Insulin Resistance
Analisis Kadar Nrf2 plasma Pada Tikus dengan Defisisensi Vitamin B12 Endin Nokik Stujanna; Irena Ujianti; Etty Farida Mustifah
Sanus Medical Journal Vol. 2 No. 1 (2021): Vol. 2 No. 1 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v1i1.6545

Abstract

Background. Vitamin B12 deficiency is a significant problem, particularly in developing countries. The increasing complexity of the Vitamin B12 molecule, the deficiency condition, causes a complex cell level disorder. The clinical manifestation of vitamin B12 deficiency is anemia, but it is believed that due to the complexity of vitamin B12, there are still other molecular disorders. This study aims to establish the pathway of damage caused by vitamin B12 deficiency in the Nrf2 molecule. Methods. An animal experiment involving 12 male Sprague Dawley rats were randomly divided into control and 16-week treatment. There are two research groups, namely the control group and the treatment group. The control group was given a standard diet, while the treatment group was assigned a vitamin B12 deficiency diet. At the end of treatment, The levels of vitamin B12 in the liver tissue and plasma NRF2 were measured. Statistical Analysis. Nrf2 and vitamin B12 levels were statistically analyzed using the Student's T-test, and the correlation between vitamin B12 and Hb was analyzed using the Spearmen test. Data that cannot use by Independent T-test were tested using the Mann Whitney test. Results/Conclusion. There was no significant difference between the control and treatment groups on plasma Nrf2 levels (4.02 ± 0.59 pg/ml vs 3.34 ± 0.55 pg/ml; p = 0.07) and tissue vitamin B12 (0.0035 ± 0.0016 µg/ml vs 0.0030 ± 0.0006 µg/ml ; p = 0.8). Keywords: Nrf2 Plasma, Defisiensi, Vitamin B12
Difficulties Differentiating Between Basal Cell Carcinoma and Trichoepithelioma: A Case Report Zahra Nurusshofa; irena ujianti
Sanus Medical Journal Vol. 2 No. 2 (2021): Vol. 2 No. 2 (2021): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v2i2.7371

Abstract

Background. Basal cell carcinoma (BCC) is the most common type of malignant skin tumor with basal cell differentiation. Trichoepithelioma (TE), however, is a rare benign skin tumor with follicular differentiation. Both types of tumor have commonalities in terms of clinical and histopathological features. Some cases, in fact, require ancillary studies to distinguish between the two. Confusing the two tumors may result in different future outcomes for the patient, due to their vastly different prognoses and treatments. This case report outlines two different cases, and discusses how to distinguish between the two types of tumor without the use of an ancillary study.Method. We examined the cases of one patient with basal cell carcinoma and one patient with trichoepithelioma, comparing their clinical manifestations and characteristic histological features.Results. Trichoepithelioma and BCC share several overlapping histopathological features. Trichoepithelioma and BCC share several overlapping histopathological features. The TE in this case report also exhibited a nodular pattern, connection to the epidermis, stromal cleft, and prominent nuclear palisading, which are more commonly found in BCC. However, scanty mitotic activity, the presence of non-atypia cells, and symmetry of the lesion, are favor TE.Conclusion. Differentiation between BCC and TE is only possible using cytomorphological assessment with a high-power field of view.
Examining Oxygen Saturation and Peak Volume Correlation in Respiratory Disorders: A Study at PCM/PCA Ciledug Rizni Fitriana; Irena Ujianti; Teguh Haryo Sasongko; Takashi Yashiro
Sanus Medical Journal Vol. 5 No. 2 (2023): Sanus Medical Journal
Publisher : Universitas Muhammadiyah Prof. Dr. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/sanus.v5i2.14488

Abstract

This cross-sectional study sought to determine the correlation between oxygen saturation and peak flow meter readings, taking into account hemoglobin levels. Participants aged 55 years and over were examined using direct measurement methods, with hemoglobin measured via the strip test method, and oxygen saturation and peak flow meter values assessed using a pulse oximeter and peak flow meter, respectively. Analysis of the collected data from 12 subjects, averaged 63 years old, revealed a significant correlation between oxygen saturation (average 96.6%) and peak flow volume (average 223.3 mL/mnt) (r=0.727, p=0.007). The findings suggest that this relationship is more potent in individuals with respiratory disorders or under certain environmental risk factors. Nonetheless, in healthier contexts, the correlation may be weaker or absent, emphasizing the need for further research to enhance the management of respiratory and lung disorders
Co-Authors Agus Rahmadi Ananda Putri Bety Semara Lakhsmi Bety Semara Lakshmi Dewi Irawati SS Endin Nokik Stujanna Endin Nokik Stujanna Etty Farida Mustifah Fahrozi Fahrozi Ibnu Albantani Imelda Rosalyn Nofrizal Nofrizal Patwa Amani Rizni Fitriana Takashi Yashiro Teguh Haryo Sasongko Wawang S Sukarya Zahra Nurusshofa Zahra Nurusshofa Zahra Nurusshofa