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Arila Atalia
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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POTENSI SUPLEMENTASI SMALL-QUANTITY LIPID-BASED NUTRIENT PRENATAL DAN POSTNATAL SEBAGAI PENCEGAHAN ANEMIA DEFISIENSI BESI PADA ANAK DI BAWAH USIA DUA TAHUN Muhammad Yusuf; Arila Atalia; Avisa Cetta Cresma
Essence of Scientific Medical Journal Vol 20 No 1 (2022): Volume 20 No. 1 (Januari - Juli 2022) Essential: Essence of Scientific Medical J
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/ESTL.2022.v20.i01.p05

Abstract

Introduction: Iron Deficiency Anemia (IDA) is considered a public health problem in Indonesia. The main consequences of IDA in infants include increased risk of permanent cognitive and psychomotor impairments that can lead to decreased quality of life in adulthood. Recommendations for iron supplementation for pregnant women and infants have uncomfortable side effects leading to poor adherence. Small Quantity Lipid-Based Nutrient Supplement (SQ-LNS) was developed as a novel iron fortification approach for pregnant and lactating women and children. The objective of this literature review is to analyze the effectiveness of SQ-LNS supplementation to prevent IDA in infants under two years of age. Methods: A Literature review was constructed with PICOS criteria and the clinical trial data were extracted from “PUBMED”, “Cochrane”, and “Europe-PMC” databases, matching the inclusion criterias. Results and Discussion: 10 studies were included in the literature review. IDA biomarkers such as Hemoglobin, serum Ferritin, and soluble transferrin receptor (sTfR) were significantly better in the SQ-LNS groups compared to control. Thus, the prevalence of anemia, iron deficiency, and iron deficiency anemia were lower in the SQ-LNS groups compared to control. SQ-LNS also optimized the level of Hepcidin and enhanced the growth and development of infants, represented by higher length-for-age z scores, weight-for-age z scores, locomotor development scores, and lower prevalence of stunting. Conclusion: SQ-LNS supplementation for pregnant women, nursing mothers, and children under two years of age has the potential to optimize Hb levels, serum Ferritin, sTfR, as well as prevent IDA in children and support child growth and development.
Potensi dan Keamanan Penggunaan Magnetic Resonance Imaging-Guided Focused Ultrasound Sebagai Terapi Penyakit Parkinson Avisa Cetta Cresma; Arila Atalia; Salsabila Farradisya
Essence of Scientific Medical Journal Vol 20 No 2 (2022): Volume 20 No. 2 (Juli - Desember 2022) Essential: Essence of Scientific Medical
Publisher : Kelompok Ilmiah Hippocrates Fakultas Kedokteran Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/essential.v20i2.84411

Abstract

Pendahuluan: Penyakit Parkinson (PP) merupakan penyakit neurodegeneratif kompleks yang terdiri dari berbagai gejala motorik dan non-motorik seiring dengan perkembangan penyakit. Peningkatan beban sosial ekonomi dan konsekuensi yang besar memerlukan penanganan tepat yang harus disesuaikan dengan prioritas dan kebutuhan masing-masing individu. Kombinasi gejala progresif PP dan efek samping pengobatan juga dapat menyebabkan penurunan kualitas hidup. Terapi yang seimbang dalam manajemen gejala dan menghindari efek samping pengobatan diperlukan dalam mengelola PP. Metode: Tinjauan ini merangkum uji klinis yang memenuhi kriteria inklusi dari hasil pencarian yang dilakukan di PUBMED, Cochrane, ScienceDirect, dan EuropePMC, dan disusun menggunakan kriteria PICOS. Pembahasan: Sebanyak 14 studi dimasukkan dalam tinjauan literatur. Fungsi motorik dan kualitas hidup pasien menunjukkan peningkatan yang signifikan setelah penggunaan prosedur MRgFUS. Namun, MRgFUS juga menyebabkan banyak kejadian buruk pada pasien baik karena kerangka stereotaktik atau gejala neurologis. Simpulan: MRgFUS merupakan terapi non-invasif yang memiliki potensi tinggi untuk meningkatkan fungsi motorik dan meningkatkan kualitas hidup pasien PP, tetapi dapat menyebabkan sejumlah kejadian buruk, baik selama prosedur maupun setelah prosedur.
Co-Authors Avisa Cetta Cresma MUHAMMAD YUSUF Salsabila Farradisya