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All Journal Narra J
Kuldeep Dhama
Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, India
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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A comprehensive review on pharmacologic agents, immunotherapies and supportive therapeutics for COVID-19 Khan Sharun; Ruchi Tiwari; Mohd I. Yatoo; Senthilkumar Natesan; Dewi Megawati; Karam P. Singh; Izabela Michalak; Kuldeep Dhama
Narra J Vol. 2 No. 3 (2022): December 2022
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v2i3.92

Abstract

The emergence of coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected many countries throughout the world. As urgency is a necessity, most efforts have focused on identifying small molecule drugs that can be repurposed for use as anti-SARS-CoV-2 agents. Although several drug candidates have been identified using in silico method and in vitro studies, most of these drugs require the support of in vivo data before they can be considered for clinical trials. Several drugs are considered promising therapeutic agents for COVID-19. In addition to the direct-acting antiviral drugs, supportive therapies including traditional Chinese medicine, immunotherapies, immunomodulators, and nutritional therapy could contribute a major role in treating COVID-19 patients. Some of these drugs have already been included in the treatment guidelines, recommendations, and standard operating procedures. In this article, we comprehensively review the approved and potential therapeutic drugs, immune cells-based therapies, immunomodulatory agents/drugs, herbs and plant metabolites, nutritional and dietary for COVID-19.
Celiac disease: Pathogenesis, disease management and new insights into the herbal-based treatments Pooja Mittal; Disha Arora; Smriti Parashar; Rajat Goyal; Amir Khan; Hitesh Chopra; Dinesh K. Mishra; Rupesh K. Gautam; Kuldeep Dhama
Narra J Vol. 3 No. 2 (2023): August 2023
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v3i2.147

Abstract

Celiac disease (CD) is a gluten intolerance autoimmune disorder which its symptoms involve the gastrointestinal tract and sometimes the other organs. It is one of the most prevalent health problems rising in many populations as statistics show that in every 100 people about one person is suffering from CD. It has been observed that the persons who genetically contain the human leukocyte antigen (HLA) DQ2 and HLA DQ8 genes involved in the immune system haplotypes are more prone to develop an allergy to gluten. The only treatment currently available for CD is a strict gluten-free diet. However, recent research has shown promising new insights into the herbal-based treatments of CD. New insight on CD is now offering various prospects to manage its treatment, diagnosis, and serving in the development of advanced therapies. Several herbs and botanical extracts have demonstrated anti-inflammatory, immunomodulatory, and gut-healing properties that make them potential candidates for the management of CD. Here, we provide an updated review on pathogeneses and managements of CD. In particular, we summarize the current understandings of herbal-based treatments for CD and highlights their potential benefits.
Co-Authors Amir Khan Dewi Megawati Dinesh K. Mishra Disha Arora Hitesh Chopra Izabela Michalak Karam P. Singh Khan Sharun Mohd I. Yatoo Pooja Mittal Rajat Goyal Ruchi Tiwari Rupesh K. Gautam Senthilkumar Natesan Smriti Parashar