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A Rare and Fatal Pulmonary Cryptococcosis in HIV/AIDS: Chronological Clinical Decline in a Middle-Aged Male Ediyono, Ediyono; Wijaya, Rike Andy; Al Amin, Yoga Dian Pratama
Jurnal sosial dan sains Vol. 5 No. 10 (2025): Jurnal Sosial dan Sains
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/jurnalsosains.v5i10.32534

Abstract

Cryptococcosis represents a life-threatening opportunistic fungal infection with significant mortality rates among immunocompromised individuals, particularly those with advanced HIV/AIDS. While cryptococcal meningitis dominates the literature, pulmonary involvement remains underrecognized despite its prognostic significance. This case report aims to document the clinical presentation, diagnostic challenges, and fatal outcome of pulmonary cryptococcosis caused by the rare species Cryptococcus laurentii in a severely immunosuppressed HIV-positive patient, and to emphasize the importance of early bronchoscopic investigation and antifungal therapy. We report the case of a 44-year-old Indonesian male with a history of HIV/AIDS who presented with progressive shortness of breath, persistent cough, and intermittent fever over two weeks. He was non-adherent to antiretroviral therapy (ART) and had a CD4 count of fewer than 50 cells/mm³. Chest radiography showed bilateral infiltrates, and sputum culture grew Cryptococcus laurentii. Despite the initiation of broad-spectrum antibiotics and antifungal agents, his respiratory status deteriorated rapidly. Antifungal susceptibility testing confirmed sensitivity to amphotericin B, flucytosine, and fluconazole, yet the patient developed progressive respiratory failure. He ultimately succumbed to refractory hypoxemia on day 23 of hospitalization. This case highlights the diagnostic challenge of pulmonary cryptococcosis in advanced HIV, particularly with rare non-neoformans species. A high index of suspicion and early mycological investigation, including culture and species-level identification, are critical for timely diagnosis. This report contributes to the limited literature on C. laurentii pulmonary infections in Southeast Asia and underscores the importance of adherence to ART, as well as the need for early consideration of fungal infections in severely immunosuppressed patients presenting with atypical pulmonary findings.
INTERNALISASI NILAI-NILAI SPIRITUAL PADA DIRI SISWA DI SMPN 2 KOTA BENGKULU Ediyono, Ediyono
Al-Bahtsu: Jurnal Penelitian Pendidikan Islam Vol 3, No 2 (2018): Al-Bahtsu: Jurnal Penelitian Pendidikan Islam
Publisher : UIN Fatmawati Sukarno Bengkulu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29300/btu.v3i2.1388

Abstract

This research  describes the condition of students’ spiritual attitudes,  methods used by Master and the constraints and support  of the internalization process  of spiritual value itself. This research  used qualitative  descriptive  and  interactive  method with observation, documentation, observation and interview. The result of the research  is that before the internalization of these spiritual values,  the condition of understanding and  religious practice  is still far from being expected. Meanwhile,  after the in- ternalization  is performed, the result of difference is increase  the awareness of students  to implement  and practice the worship, especially mandatory prayer  in congregation. Morals and  behaviors are increase  and  the respect  for teachers  also increase  so that  this affects the increase  in student  achievement itself. Methods  used  include  Teacher  Role Improvement Method,  Guid- ance  and  Counseling Method,  Tauladan Method,  Cultural  Method,  and  Tabligh Method.  While the inhibiting  factors are  the background of family conditions  and the limited role of teachers  in conducting guidance and learning.  The supporting factor is the application of K-13 curriculum  which is very compatible with the activities of spiritual values in the students.  The teachers awareness in giving tauladan to their students  also increase