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in silico Study Reveals Potential Docking Sites of δ 2-isoxazolines derivates for Inhibiting Russell’s Viper PLA2 Toxin Tsaniyah Nur Kholilah; Nashi Widodo; Nia Kurniawan
Journal of Tropical Life Science Vol. 11 No. 1 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.01.06

Abstract

Snake venom phospholipase A2s (svPLA2s) has been known as the most abundant component and predominant cause of Russell’s viper envenomation. Limitation to serum therapy and considerable pharmacological interest led the researcher to synthesized multi-toxic PLA2 inhibitors, δ2-isoxazolines derivate. Although δ2- isoxazolines derivate already proved inhibitor activity in Group II svPLA2 with known IC50, their mechanism of action remains unveiled. Our recent study investigated their inhibitory activity via molecular docking. The virtual screening revealed that the ligand with diverse structures tied to the relatively same active site region. The result sheds light on the significance of His48 and Asp49 as part of the pro-inflammatory eliciting region. ADME analysis was also performed to filter and identify the best potential inhibitor acceptable for human use. This moiety leads to finding a better therapeutic strategy of svPLA2 inhibitors both as an alternative to serum anti-venom treatment.
Varanus salvator As an Indicator of Turtle Nesting Season at Ngagelan Beach, Alas Purwo National Park (TNAP), Indonesia: A Conservatiom Effort Siti Roudlotul Hikamah; Hariyanto Hariyanto; Nia Kurniawan
Al-Kauniyah: Jurnal Biologi Vol 16, No 2 (2023): AL-KAUNIYAH JURNAL BIOLOGI
Publisher : Department of Biology, Faculty of Science and Technology, Syarif Hidayatullah State Islami

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/kauniyah.v16i2.26962

Abstract

AbstractVarious turtle conservation efforts continue to be carried out, including protecting the eggs from predators. The study aimed to describe the behavior of turtles laying eggs using Varanus salvator as an indicator. The research was conducted at Ngagelan Beach, Alas Purwo National Park (TNAP), and around the Semi Natural Turtle Hatchery (PPSA), Banyuwangi, Indonesia. The research was conducted from January to December 2019. The type of research is quantitative and qualitative. The study results indicated that Varanus salvator visited this area only during the turtle nesting season. Lepidochelys olivacea dominates the types of turtles that land in TNAP. 1,056 L. Olivacea, 6 Chelonia mydas, Eretmochelys imbricata, and Dermochelys coriacea landed only one animal to lay eggs. Landing occurs from April to August, with peak landing in June. Varanus salvator was found roaming the area starting April, peaking in the second week of August and decreasing in October. Differences in landing time and arrival behavior of Varanus salvator are related to the incubation period of 40–50 days of turtle eggs. The smell of turtle eggs and dead hatchlings beckons V. salvator to this area. This behavior is because Varanus salvator has a strong sense of smell, detected by frequent tongue flicking.AbstrakBerbagai upaya konservasi penyu terus dilakukan, salah satunya melindungi telur dari pemangsa. Tujuan penelitian untuk mendeskripsikan perilaku penyu bertelur menggunakan Varanus salvator sebagai indikator serta upaya konservasii. Penelitian dilakukan di Pantai Ngagelan, Taman Nasional Alas Purwo (TNAP), dan di sekitar Penangkaran Penyu Semi Alami (PPSA), Banyuwangi, Indonesia. Penelitian dilakukan bulan Januari-Desember 2019. Jenis penelitian adalah kuantitatif dan kualitatif. Data yang diperoleh dianalisis secara deskriptif kulitatif dan korelasi. Hasil penelitian menginformasikan bahwa V. salvator mengunjungi daerah ini hanya pada musim penyu bertelur; mereka melakukan perjalanan ke daerah lain ketika bukan musim penyu bertelur. Lepidochelys olivacea mendominasi jenis penyu yang mendarat di TNAP. Sebanyak 1.056 L. Olivacea, 6 Chelonia mydas, Eretmochelys imbricata, dan Dermochelys coriacea masing-masing hanya satu satwa mendarat untuk bertelur. Pendaratan terjadi pada bulan April hingga Agustus, puncak pendaratan pada bulan Juni. V. salvator ditemukan berkeliaran di daerah ini mulai bulan April, memuncak pada minggu kedua Agustus dan menurun bulan Oktober. Perbedaan waktu pendaratan dan perilaku kedatangan V. salvator berkaitan dengan masa inkubasi telur penyu berkisar antara 40–50 hari. Bau telur penyu dan tukik mati mengundang V. salvator ke kawasan ini. Perilaku ini karena V. salvator memiliki indera penciuman yang kuat, terdeteksi oleh lidah yang sering dijentikkan.