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All Journal e-CliniC Glosains: Jurnal Sains Global Indonesia
Shienty Gaspersz
Universitas Sam Ratulangi
Health Professions

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Bullous Pemphigoid Treated with Corticosteroid: A Case Report Dwi M. Trisnowati; Hyacintha P. Budi; Shienty Gaspersz; Meilany Durry
e-CliniC Vol. 10 No. 2 (2022): e-CliniC
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.v10i2.41403

Abstract

Abstract: Bullous pemphigoid (BP) is an autoimmune disease clinically characterized by pruritic, large, tense subepidermal bullae over normal skin, erythematous or urticarial plaques. The pathogenesis related to the immune system towards BP antigen 180 and 230. Mild lesions may be treated with topical corticosteroid but the more extensive lesions are treated with oral corticosteroids. We reported a case of 58-year-old man came with clear fluid-filled blisters on the body since a week ago. Dermatological examination revealed multiple vesicle-bullae, filled with clear fluid, tense walls. Nikolsky sign and Asboe-Hansen sign were negative. Histopathological examination supported the diagnosis of BP. Diagnosis was established based on anamnesis, and physical and histopathological examinations. The patient was treated with systemic corticosteroid due to the consideration of the extensive lesions. Methylprednisolon was given intravenously at a dose of 43.75 mg per day which was then replaced orally for tapering off. The dose reduction of 4 mg per week was carried out according to the clinical improvement. In conclusion, this case improved after being treated with systemic corticosteroid for approximately 2-3 months.Keywords: bullous pemphigoid; corticosteroid Abstrak: Pemfigoid bulosa (PB) merupakan penyakit bula autoimun ditandai dengan pruritus dan bula subepidermal besar berdinding tegang di atas kulit yang normal, eritematosa atau plak urtikaria. Patogenesisnya berhubungan dengan sistem kekebalan tubuh yaitu respons imun terhadap antigen BP 180 dan 230. Penatalaksanaan untuk lesi ringan diberikan kortikosteroid topikal, sedangkan untuk lesi luas dengan kortikosteroid sistemik. Kami melaporkan seorang laki-laki berusia 58 tahun dengan keluhan lepuh-lepuh berisi cairan jernih pada hampir seluruh tubuh sejak satu minggu lalu. Pada pemeriksaan fisik ditemukan vesikel-bula, multipel, berisi cairan jernih, dinding tegang. Pemeriksaan tanda Nikolsky dan Asboe-Hansen negatif. Pemeriksaan histopatologik mendukung diagnosis PB. Tatalaksana yang diberikan berupa kortikosteroid sistemik karena pertimbangan lesinya yang luas. Metilprednisolon diberikan secara intravena dengan dosis 43,75 mg per hari yang kemudian diganti pemberian per oral saat tapering off. Penurunan dosis 4 mg metilprednisolon per minggu dilakukan sesuai dengan perbaikan kondisi klinis. Simpulan kasus ini ialah pemfigoid bulosa yang mengalami perbaikan setelah diterapi dengan kortikosteroid sistemik selama kurang lebih 2-3 bulan.Kata kunci: pemfigoid bulosa; kortikosteroid
Serum Vitamin D Levels and Severity of Male Androgenetic Alopecia in North Sulawesi: A Cross-Sectional Study Thigita Aga Pandaleke; Aryani Adji; Shienty Gaspersz; Dwayne Giovano Pandaleke; Paulus Mario Christopher
Glosains: Jurnal Sains Global Indonesia Vol. 7 No. 3 (2026): Glosains: Jurnal Sains Global Indonesia
Publisher : Sekolah Tinggi Agama Islam Kuningan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59784/glosains.v7i3.748

Abstract

Background: Androgenetic alopecia (AGA) is the most prevalent type of nonscarring hair loss in men, leading to progressive miniaturization of hair follicles and shortened hair growth cycles. Recent evidence indicates the importance of vitamin D and vitamin D receptor-mediated signaling in regulating hair follicle function. Nevertheless, studies investigating this relationship among Indonesian men remain limited. Objective: To investigate the relationship between serum vitamin D levels and the severity of AGA using the Hamilton–Norwood classification in men. Methods: This cross-sectional analytical study included 30 male patients aged 18–70 years who visited a tertiary referral hospital in North Sulawesi and were diagnosed with AGA. AGA severity was classified as mild, moderate, or severe according to the Hamilton–Norwood classification. Serum vitamin D concentrations were assessed, and Spearman’s rank correlation test was used to evaluate the association between vitamin D levels and AGA severity, with p < 0.05 considered statistically significant. Results: The patients’ mean age was 40.27 ± 11.40 years, and the mean duration of AGA was 8.87 ± 6.58 years. The overall mean serum vitamin D level was 26.56 ± 11.36 ng/mL, with the majority (80%) of subjects classified as vitamin D deficient. A progressive decrease in vitamin D levels was observed with increasing AGA severity (mild: 36.34 ± 14.27 ng/mL; moderate: 22.77 ± 4.90 ng/mL; severe: 20.54 ± 5.09 ng/mL). Statistical analysis revealed a significant negative correlation between serum vitamin D levels and AGA severity (r = −0.57; p = 0.001). Conclusions: In this cross-sectional study, lower serum vitamin D concentrations were significantly associated with greater AGA severity (r = −0.57; p = 0.001). These findings suggest a potential role of vitamin D in the pathogenesis of AGA; however, causality cannot be established based solely on this study design.
Co-Authors Aryani Adji Dwayne Giovano Pandaleke Dwi M. Trisnowati Hyacintha P. Budi Meilany Durry Paulus Mario Christopher Thigita Aga Pandaleke