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All Journal Jurnal Pendidikan Kimia Indonesia Biology, Medicine, & Natural Product Chemistry Jurnal Penelitian Pendidikan IPA (JPPIPA) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Medical Sains : Jurnal Ilmiah Kefarmasian
Laili Nailul Muna
UIN Sunan Kalijaga
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Health Professions Materials Science & Nanotechnology Medicine & Pharmacology Physics Public Health

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Chemistry Craft and Entrepreneurship Practicum Module Based on Semi-Solid Preparations as a Learning Resource for High School Students Luthfiana Dewi; Laili Nailul Muna
Jurnal Pendidikan Kimia Indonesia Vol. 6 No. 2 (2022)
Publisher : Universitas Pendidikan Ganesha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jpki.v6i2.44325

Abstract

The learning activities applied are still dominated by textbooks, so additional learning resources are needed to support more creative and innovative learning activities. This study aims to create a semi-solid preparation-based chemical practicum module for craft and entrepreneurship (PKWU) as a learning resource for SMA/MA students. The type of research used is development research (R&D) with the 4D development model. The research subjects included one material expert, a media expert, four reviewers, and ten SMA/MA MIPA students. Quality assessment was carried out using a Likert scale questionnaire sheet and a Guttman scale questionnaire. The analysis technique uses quantitative and qualitative analysis. The results of the assessment show that material experts are 90.77% in the Very Good category, product ratings by media experts are 96.7% in the Very Good category, and the reviewer's assessment (chemistry teacher) gets an average score of average with a percentage of 90.25% in the Very Good category. The results of student responses to the module show a percentage of 95%. The results show that the PKWU practicum module based on semisolid preparations is feasible to use as an alternative learning resource in increasing student understanding. This research implies that teachers are expected to be able to use practicum modules that can facilitate students in carrying out practicum activities.
Formulasi dan Uji Sifat Fisik Sediaan Ekstrak Etanolik Gel Ekstrak Kulit Lemon berbasis Karbomer 940 Laili Nailul Muna
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 4, No 1 (2023): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v4i1.11307

Abstract

Penuaan kulit merupakan proses biologi yang terjadi pada sel seiring bertambahnya waktu, hal ini dapat disebabkan karena paparan radikal bebas dari sinar UV. Kulit buah lemon mengandung Vitamin C yang mampu mengurangi derajat eritema serta mempunyai aktivitas antioksidan yang mampu menghambat radikal bebas. Penggunaan secara tradisional membutuhkan persiapan yang lama, sehingga diperlukan sediaan dengan formulasi khusus agar lebih praktis dan awet. Sediaan gel dipilih karena memberikan rasa nyaman di kulit. Tujuan penelitian adalah membuat formulasi dan menguji sediaan terhadap parameter sifat fisik gel ekstrak etanolik kulit buah lemon dengan perbandingan rasio basis Carbomer 940. Formula dalam pembuatan sediaan gel mempengaruhi hasil uji sifat fisik gel. Pada penelitian ini dilakukan 2 formula gel dengan perbandingan rasio basis carbomer 940 pada formula satu sebesar  0,5% dan  formula dua sebesar 1,5%. Selanjutnya dilakukan uji sifat fisik sediaan yakni homogenitas, organoleptis, pH, daya sebar, daya lekat, dan kemampuan proteksi. Hasil penelitian menunjukkan bahwa pada hasil uji sifat fisik sediaan homogenitas dan pH menunjukkan hasil yang baik. Pada pengujian daya sebar dan daya lekat tidak memenuhi kriteria, sedangkan pada pengujian kemampuan proteksi hanya formula dua yang memperlihatkan hasil proteksi.
The Influence of the Discovery Learning Learning Model on Critical Thinking Abilities and Student Learning Outcomes in Buffer Solution Material Sri Ayuningsih; Laili Nailul Muna
Jurnal Penelitian Pendidikan IPA Vol. 9 No. 11 (2023): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i11.4469

Abstract

This research aims to determine the effect of the discovery learning model on critical thinking skills and student learning outcomes in buffer solution material for class XI MIPA at SMA Negeri 1 Kejobong. This research uses a quasi-experimental type of research which was carried out in March – April 2023. The sampling technique used was cluster random sampling. The population consists of three classes XI MIPA, totaling 101 students. The samples used were class XI MIPA 1 as an experimental class with a total of 31 students and class XI MIPA 2 as a control class with a total of 34 students. The instruments used were critical thinking ability questionnaires and multiple choice questions. The results of this research indicate that the use of the discovery learning model in learning buffer solution material can improve critical thinking skills and student learning outcomes. This is evident from the average critical thinking ability score of experimental class students of 58.32 while the control class is 55.29. The average value of student learning outcomes for the experimental class was 84.77 and the control class was 79.53. The conclusion from the results of this research is that there is an influence of the discovery learning model on critical thinking skills and student learning outcomes in buffer solution material for class XI MIPA at SMA Negeri 1 Kejobong.
The Influence of the Discovery Learning Learning Model on Critical Thinking Abilities and Student Learning Outcomes in Buffer Solution Material Sri Ayuningsih; Laili Nailul Muna
Jurnal Penelitian Pendidikan IPA Vol 9 No 11 (2023): November
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i11.4469

Abstract

This research aims to determine the effect of the discovery learning model on critical thinking skills and student learning outcomes in buffer solution material for class XI MIPA at SMA Negeri 1 Kejobong. This research uses a quasi-experimental type of research which was carried out in March – April 2023. The sampling technique used was cluster random sampling. The population consists of three classes XI MIPA, totaling 101 students. The samples used were class XI MIPA 1 as an experimental class with a total of 31 students and class XI MIPA 2 as a control class with a total of 34 students. The instruments used were critical thinking ability questionnaires and multiple choice questions. The results of this research indicate that the use of the discovery learning model in learning buffer solution material can improve critical thinking skills and student learning outcomes. This is evident from the average critical thinking ability score of experimental class students of 58.32 while the control class is 55.29. The average value of student learning outcomes for the experimental class was 84.77 and the control class was 79.53. The conclusion from the results of this research is that there is an influence of the discovery learning model on critical thinking skills and student learning outcomes in buffer solution material for class XI MIPA at SMA Negeri 1 Kejobong.
IDENTIFICATION OF PHYSICOCHEMICAL PROPERTIES, PHARMACOKINETICS AND TOXICITY OF ACTIVE COMPOUNDS OF Kaempferia galanga RHIZOME Laili Nailul Muna
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 1 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i1.774

Abstract

The Kencur plant has many benefits, is economically valuable, and is widely cultivated by the local community. The development of kencur compounds has not been carried out optimally because of the relatively high cost of identifying the content of each compound. This study aimed to determine the physiochemical properties of kencur compounds and their pharmacokinetics, as well as the toxicity of the herb kencur rhizome in silico. The method used in this study uses a Marvin sketch to draw the structure of the compound, which was then analyzed using Lipinski to determine its physico-chemical properties. Pharmacokinetic and toxicity analyses were performed using the pKCSM software. The results showed that all compounds followed Lipinski's rules; therefore, predictably, they could be developed into drug molecules from these compounds. In addition, all compounds had fairly high Water Solubility (log S). All HIA compounds were >90%, so they were well absorbed in the intestine and showed good permeability to CaCO-2 with a log Papp value of > 0.90. All the above compounds have low permeability to the skin due to the log Kp value > -2.5, so they are not suitable for transdermal preparations. Keywords: Physicochemistry, Pharmacokinetics, Toxicity, Kencur, In silico
Development of Co-Chemotherapeutic Agents and Analysis of the Active Substance Content of Red Ginger (Zingiber officinale Var Rubrum rhizoma) in Metastatic Breast Cancer Cells Laili Nailul Muna; Enny Riyan Hasni; Farhatul Uyun; Erna Wulandari
Biology, Medicine, & Natural Product Chemistry Vol 14, No 2 (2025)
Publisher : Sunan Kalijaga State Islamic University & Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14421/biomedich.2025.142.1451-1458

Abstract

Metastatic breast cancer also known as stage IV breast cancer. Current chemotherapy agents have several limitations, such as resistance events, side effects, and inadequate efficacy in advanced cancer. It is necessary to develop a more effective chemotherapy model, namely the development of co-chemotherapy agents derived from natural ingredients that have activity in counteracting oxidative stress and preventing metastatic breast cancer, namely red ginger. GC-MS analysis of red ginger oleoresin showed the composition of chemical compounds influenced by variants of soxletation time of 60, 120, and 180 minutes. GC-MS analysis showed that this essential oil consists of volatile compounds, mainly from the sesquiterpene group and namely zingiberene, betha-sesquiphellandrene, betha-bisabolene and ar-curcumene. The results of the cytotoxic test analysis of red ginger extract with socletation time for 60, 120 and 180 minutes respectively obtained IC50 data as follows with 45.16 µg/ml, 37.23 µg/ml and 20.2 µg/ml. The compounds contained in red ginger, such as zingiberene, gingerol, shogaol, flavonoids, phenolics, alkaloids, saponins, and tannins, play an important role in its cytotoxic effect against cancer cells. The mechanism by which alpha-Zingiberene induces cell death in cancer cells is mainly through the apoptotic process. The compound causes the release of mitochondrial cytochrome c into the cytoplasm, which then activates caspase-3, an apoptotic enzyme.
Co-Authors Enny Riyan Hasni Erna Wulandari Farhatul Uyun Luthfiana Dewi Sri Ayuningsih