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All Journal Indonesian Journal of Chemistry
Wahyu Dita Saputri
Research Center for Quantum Physics, National Research and Innovation Agency (BRIN), Habibie Science and Technology Complex (Puspiptek), Serpong 15314, South Tangerang, Indonesia
Chemical Engineering, Chemistry & Bioengineering Chemistry

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Synthesis of N-phenethyl-p-methoxycinnamamide and N-morpholinyl-p-methoxycinnamamide, In Vitro and In Silico Study as α-Glucosidase Inhibitor Herlina Rasyid; Firdaus Firdaus; Syadza Firdausiah; Nunuk Hariani Soekamto; Seniwati Seniwati; Riska Mardiyanti; Reynaldi Reynaldi; Andi Eka Sri Rahayu; Wahyu Dita Saputri
Indonesian Journal of Chemistry Vol 22, No 6 (2022)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.76802

Abstract

Aromatic ginger (Kaempferia galanga L.) is one of the natural sources containing ethyl-p-methoxycinnamate, which is known to have beneficial activity, especially as an α-glucosidase inhibitor. This study aims to convert ethyl-p-methoxycinnamate into amide form as N-phenethyl-p-methoxycinnamamide (4a) and N-morpholinyl-p-methoxycinnamamide (4b) through some synthetic ways then tested their activity as an α-glucosidase inhibitor. The FTIR spectra of 4a present a short single peak at 3269.34 cm−1 that belongs to the N-H group, while spectra of 4b show no absorption band between 3200–3400 cm−1 due to its tertiary amide structure. Spectroscopy analysis through 1H- and 13C-NMR exhibits the successful synthesis of both compounds. Bioactivity test results show that compound 4b has better activity than 4a. In molecular dynamics simulation, the binding energy of compounds 4a and 4b reveal that both compounds have a similar binding energy of about -98980.8 and -97696.7 kJ mol−1, respectively.
Activity and Selectivity of Mesoporous Silica Catalyst for Hydrocracking Process of Used Palm Oil into Biogasoline Ahmad Suseno; Karna Wijaya; Edy Heraldy; Lukman Hakim; Wahyu Dita Saputri; Gunawan Gunawan
Indonesian Journal of Chemistry Vol 23, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijc.70460

Abstract

Research on the synthesis of mesoporous silica catalyst, as well as its activity and selectivity in the hydrocracking of used palm oil, has been carried out. The research involved the preparation of mesoporous silica catalyst by varying the volume ratio of TEOS:CTAB at 2:1, 4:1, and 8:1, then calcined at 500 °C. Synthesis success was confirmed by FTIR, XRD, SEM-EDX, GSA, and hydrocracking selectivity by GC-MS analysis. The results showed that the more TEOS added, the silica bond composition, crystallinity, pore size, and product selectivity increased. The best catalyst performance was obtained from a TEOS:CTAB ratio of 8:1 at a calcination temperature of 500 °C (MCT81-500), which indicated the presence of Si-OH and Si-O-Si groups with a Si percentage of 45.31%, pore size diameter of 31.912 nm, and a total pore volume of 0.040 cc/g. In addition, the application of MCT81-500 in the hydrocracking process of used palm oil can produce a bio-gasoline (C5-C12) and kerosene (C12-C15) of 92.24 and 7.76 wt.%, respectively. This study shows that mesoporous silica has good potential for catalytic activity to convert used cooking oil waste into an environmentally friendly energy source.
Co-Authors Ahmad Suseno Andi Eka Sri Rahayu Edy Heraldy Firdaus Firdaus Gunawan Gunawan Herlina Rasyid Karna Wijaya Lukman Hakim Nunuk Hariani Soekamto Reynaldi Reynaldi Riska Mardiyanti Seniwati Seniwati Syadza Firdausiah