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Fitria Susilowati
Program Studi Gizi, UIN Walisongo Semarang
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Mass Spectrometry (MS) Profiling on Potent Anticancer Fractions of Calthropella sp. Fitria Susilowati
Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy Vol 6, No 2 (2022): September
Publisher : University Of Darussalam Gontor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21111/pharmasipha.v6i2.8630

Abstract

A research on isolation and in vitro cytotoxic assay of active fractions of marine sponge Calthropella sp. from Krakal Beach Gunungkidul had been carried out. This study aims to analyze the Mass Spectrometry (MS) profile of potent anticancer fractions of marine sponge Calthropella sp. The two potent fractions (F1 and F2) were analyzed by High Resolution Liquid Chromatography-Mass Spectrometry (HR LC-MS) to identify the compounds exist in each fractions. The LC-MS analyses were conducted on the best elution system, isocratic elution of 80% MeCN (with 0.1% formic acid) + 20% milliQ H2O (with 0.1% formic acid). Based on LC-MS analyses, it is strongly predicted that F1 consist of 4'-N-methyl-5'- hydroxystaurosporine, 24-methyleneergost-4-ene-3-one, and one new compound. F2 is predicted to consist bengamide Q, clavepictine A, 4'-N-methyl-5’-hydroxystaurosporine, biemnic acid, carteriofenone A, and one new compound 
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