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Studi Retrospektif: Vaginosis Bakterial Pujiastuti, Agustina Tri; Murtiastutik, Dwi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol 26, No 2 (2014): BIKKK AGUSTUS 2014
Publisher : Faculty Of Medicine Airlangga University

Latar belakang: Vaginosis bakterial (VB) adalah sindrom klinis akibat pergantian Lactobacillus spp. penghasil hidrogen peroksidase (HO) dalam vagina normal dengan bakteri anaerob konsentrasi tinggi, Gardnerella vaginalis dan Mycoplasma 22hominis. VB merupakan penyebab keluhan duh tubuh vagina dan keputihan berbau, namun 50% pasien VB tidak memberikan gejala apapun. Tujuan: Mengevaluasi gambaran umum kasus baru VB di Divisi Infeksi Menular Seksual (IMS) Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya periode tahun 2007-2011. Metode: Penelitian dilakukan secara retrospektif dengan melihat catatan medik kasus baru VB yang meliputi data dasar, anamesis, pemeriksaan fisik dan pemeriksaan penunjang. Hasil: Jumlah kasus baru VB adalah 35 pasien dari 33.201 (0,1%) kunjungan baru URJ Kesehatan Kulit dan kelamin RSUD Dr. Soetomo Surabaya, dengan kelompok usia terbanyak 25-44 tahun sebesar 26 (74,3%) pasien dan 31 pasien (88,6%) sudah menikah. Keluhan utama terbanyak berupa duh tubuh vagina tanpa keluhan subjektif yaitu sebanyak 16 (45,7%) pasien. Duh tubuh vagina terbanyak berbentuk serosa pada 25 (71,4%) pasien. Pada pemeriksaan laboratorium ditemukan clue cell pada 100% kasus. Obat yang paling banyak diberikan berupa metronidazol. Simpulan: Gambaran umum kasus baru VB di RSUD Dr. Soetomo Surabaya menunjukkan insidensi kecil, sebagian besar pada kelompok usia seksual aktif dan keluhan utama terbanyak yaitu duh tubuh vagina tanpa disertai keluhan subjektif lainnya.Kata kunci: vaginosis bakterial, keputihan, bau, clue cell.

Studi Retrospektif: Vaginosis Bakterial Agustina Tri Pujiastuti; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 26 No. 2 (2014): BIKKK AGUSTUS 2014
Publisher : Faculty of Medicine, Universitas Airlangga

Latar belakang: Vaginosis bakterial (VB) adalah sindrom klinis akibat pergantian Lactobacillus spp. penghasil hidrogen peroksidase (HO) dalam vagina normal dengan bakteri anaerob konsentrasi tinggi, Gardnerella vaginalis dan Mycoplasma 22hominis. VB merupakan penyebab keluhan duh tubuh vagina dan keputihan berbau, namun 50% pasien VB tidak memberikan gejala apapun. Tujuan: Mengevaluasi gambaran umum kasus baru VB di Divisi Infeksi Menular Seksual (IMS) Unit Rawat Jalan (URJ) Kesehatan Kulit dan Kelamin RSUD Dr. Soetomo Surabaya periode tahun 2007-2011. Metode: Penelitian dilakukan secara retrospektif dengan melihat catatan medik kasus baru VB yang meliputi data dasar, anamesis, pemeriksaan fisik dan pemeriksaan penunjang. Hasil: Jumlah kasus baru VB adalah 35 pasien dari 33.201 (0,1%) kunjungan baru URJ Kesehatan Kulit dan kelamin RSUD Dr. Soetomo Surabaya, dengan kelompok usia terbanyak 25-44 tahun sebesar 26 (74,3%) pasien dan 31 pasien (88,6%) sudah menikah. Keluhan utama terbanyak berupa duh tubuh vagina tanpa keluhan subjektif yaitu sebanyak 16 (45,7%) pasien. Duh tubuh vagina terbanyak berbentuk serosa pada 25 (71,4%) pasien. Pada pemeriksaan laboratorium ditemukan clue cell pada 100% kasus. Obat yang paling banyak diberikan berupa metronidazol. Simpulan: Gambaran umum kasus baru VB di RSUD Dr. Soetomo Surabaya menunjukkan insidensi kecil, sebagian besar pada kelompok usia seksual aktif dan keluhan utama terbanyak yaitu duh tubuh vagina tanpa disertai keluhan subjektif lainnya.Kata kunci: vaginosis bakterial, keputihan, bau, clue cell.

Oral Hairy Leukoplakia in Patient with HIV/AIDS Agustina Tri Pujiastuti; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 28 No. 1 (2016): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Oral hairy leukoplakia (OHL) is an asymptomatic white plaque with vertical corrugations most commonly found on the lateral borders of the tongue. It is caused by local infection of Epstein- Barr Virus (EBV). OHL is usually associated with immunocompromised condition, and mainly described in patients with human immunodeficiency virus (HIV). Purpose: to report a case of oral hairy leukoplakia in an HIV patient that is often misdiagnosed as oral candidasis. Case: A 44-years old female came to the Dermato-Venereology Outpatient Clinic of Dr. Soetomo General Hospital Surabaya with complaint of persistent asymptomatic whitish color on both borders of her tongue. History taking revealed that at first the whitish color appeared spreading on the tongue, but after taking antifungal treatment, only the lesion on the borders still persisted, all attempts to scrub off the lesion failed. There were also history of diarrhea, fever and cough for almost 1 month. Further examination of HIV antibody 3 method tests revealed reactive result with CD4+ count of 1 cel/uL. Physical examination revealed bilateral painless white well demarcated plaque with “hairy” like corrugated appearance on the lateral borders of the tongue. Discussion: From history, clinical findings, and the reactive HIV antibody examination, the patient was diagnosed with AIDS with oral hairy leukoplakia. The patient was treated with acyclovir 200 mg, 5 times daily. After 2 weeks of treatment, clearance was achieved. Conclusion: The establishment of OHL which oftenly mistaken as oral candidiasis has a diagnostic value for HIV infection. Systemic antiviral institution and antiretroviral (ARV) medications as prevention for recurrence gave satisfying result. Key words: oral hairy leukoplakia, HIV, acyclovir.

Profile of Serum Interferon Gamma Induced Protein 10 in Borderline Leprosy Patients with and without Type 1 Leprosy Reaction Agustina Tri Pujiastuti; Indropo Agusni; Rahmadewi Rahmadewi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 29 No. 3 (2017): DESEMBER
Publisher : Faculty of Medicine, Universitas Airlangga

Background: Leprosy reaction is an acute episode in leprosy characterized by acute inflammation sometimes accompanied with systemic symptoms. Leprosy type 1 reaction often occurs in borderline leprosy patients. Leprosy type 1 reaction can cause peripheral nerve damage through neuritis that can lead to disability. Interferon-γ induced protein 10 (IP10) is a chemokine with chemotaxis function to various immune cells such as macrophage, dendritic cells, Natural Killer cells, and activated T lymphocites. Several studies have found an increase of IP10 serum level when type 1 reaction occurred. Purpose: To evaluate the profile of IP10 serum levels in borderline patients with and without type 1 leprosy reaction. Methods: This is a descriptive cross-sectional study, with 34 borderline leprosy patients of which 17 had leprosy type 1 reaction and 17 without reaction that qualify inclusion and exclusion criteria. Results: Mean serum IP10 levels in leprosy type 1 reaction groups are 594,123 ± 327,628 pg/mL and 331,648 ± 101,819 pg/mL in groups without reaction. Conclusions: Serum IP10 levels in borderline leprosy patient with type 1 reaction is higher than patients without reaction, although confounding factors in borderline leprosy patients with type 1 reaction that can influence serum IP10 levels cannot be eliminated. Further studies are needed to reveal the role of IP`10 in type 1 leprosy reaction.

The Effectiveness of HPV Vaccine in Cervical Cancer Prevention: A Literature Review juandi, rahma khaerussifa; Pujiastuti, Agustina Tri
Journal of Diverse Medical Research: Medicosphere Vol. 2 No. 5 (2025): J Divers Med Res 2025
Publisher : Faculty of Medical - UPN Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v2i5.114

Cervical cancer is one of the leading causes of death in women worldwide, with more than 600,000 cases and 342,000 deaths occurring in 2020. The World Health Organization (WHO) has set a global strategy to eliminate cervical cancer by 2030, where Human Papillomavirus (HPV) vaccination is one of its main pillars. In Indonesia, the HPV vaccination program has been implemented as a preventive measure in preventing cervical cancer, with the main target being girls aged 9 to 14 years. HPV vaccines, especially types 16 and 18, have been shown to be effective in preventing more than 70% of cervical cancer cases. This literature review evaluates the effectiveness of the HPV vaccine in girls in Indonesia and the challenges in its implementation. Although the national vaccination program has been successfully implemented in various regions, challenges such as socio-economic, myths about vaccines, and rejection from parents are still obstacles in achieving optimal vaccination coverage. Continuous education to the public is essential to build a better understanding of the benefits of HPV vaccination in preventing cervical cancer. With higher vaccination coverage, it is hoped that the incidence rate of cervical cancer can be significantly reduced in the future.

The Management of Urticaria Pigmentosa: A Literature Review Pujiastuti, Agustina Tri
Journal of Diverse Medical Research: Medicosphere Vol. 1 No. 5 (2024): J Diverse Med Res
Publisher : Faculty of Medical - UPN Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v1i2.4

ABSTRACT Background: Urticaria pigmentosum is the most common skin manifestation of cutaneous mastocytosis. This disease has similarity with others, therefor misdiagnose is common occurrence. Methods. Literature searching was conducted using databases such as PubMed, Google Scholar, and Web of Science using Search terms included "urticaria," "mastocytosis," "treatment," and "mast cell.". Systematic reviews of peer-reviewed articles, reports, and case studies were chosen. Discussion: The management of urticaria pigmentosa consists of three lines of therapy, which can be utilized based on each patient’s response. Conclusion: The proper management of urticaria pigmentosum is important to eliminate symptoms and improve the patient’s quality of life. Key words: Urticaria pigmentosum, mastocytosis, management

Current Perspective of Diagnostic and Treatment of Rhinitis: A Literature Review Karenina, Lovenita Visca; Pujiastuti, Agustina Tri
Journal of Diverse Medical Research : Medicosphere Vol. 1 No. 2 (2024): J Divers Med Res 2024
Publisher : Faculty of Medical - UPN Veteran Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33005/jdiversemedres.v1i2.133

ABSTRACT Background: Rhinitis is an inflammation or irritation of the nasal mucosa that characterized by symptoms such as runny nose, nasal congestion, and sneezing. This condition can also be caused by inflammation of eyes, ears, and throat. Objective: To review the literature on vasomotor rhinitis, allergic rhinitis, the relationship between rhinitis and students’ quality of life, and rhinitis in sports athletes. Methods: This literature review was conducted by selecting a topic and determining keywords for journal searches using English and Indonesian through several databases including Google Scholar and NCBI Bookshelf. Results: This literature review shows that vasomotor rhinitis and allergic rhinitis have different causes and treatments, although both show similar symptoms. Conclusion: This literature review shows that vasomotor rhinitis and allergic rhinitis have different causes and treatments, although both show similar symptoms. Keywords: Allergic rhinitis, vasomotor rhinitis

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