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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan
Yulistia Budianti Soemarie Arina Swastika Maulita, Yulistia Budianti Soemarie
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Pengembangan Matrik Lepas Lambat Berbasis EC – PVP K30 Menggunakan Teknik Dispersi Solida Dengan Model Obat Natrium Diklofenak Arina Swastika Maulita, Yulistia Budianti Soemarie
Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Vol 2, No 1 (2012): Januari
Publisher : University of Muhammadiyah Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (235.74 KB) | DOI: 10.22219/far.v2i1.1162

Abstract

This research is a modification of controlled release which beneficially to optimize the medicine reaction and to minimize the fluctuation of blood level in a certain period of the release. The aim of research is to develop the matrix  system in ethylcellulose basic PVP K30 which applies dispersion solid method using sodium diclofenac as sample. Resulted four formulas consist of PVP K30 percentages as follow 0%, 5%, 10% and 20%. The different percentages of PVP K30 is aimed to know the formula which produces the releasing result of ND more optimal. This research produces in each formula significant differences (p<0,05). The formula whole percentages of PVP K30 10% has completed the requirements of control release better than the other one, shown the better resistance characteristics and release profile.
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