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All Journal EduChemia: Jurnal Kimia dan Pendidikan
Lia Meilawati
Pusat Penelitian Kimia Lembaga Ilmu Pengetahuan Indonesia Kawasan Puspiptek, Tangerang Selatan 15314
Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology

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Phytochemical Screening, Antioxidant, Antidiabetic Activity, and Toxicity of Melastoma malabathricum L. Leaves Lia Meilawati; Megawati Megawati; Indah Dwiatmi Dewijanti; Mamay Maslahat
EduChemia (Jurnal Kimia dan Pendidikan) Vol 7, No 1 (2022)
Publisher : Department of Chemical Education Faculty of Teacher Training and Education Universitas Su

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30870/educhemia.v7i1.12481

Abstract

Extraction and fractionation have been carried out to determine the content of compounds in Harendong (Melastoma malabathricum L.) leaves, antioxidant test using the 1,1-diphenyl-2-picrylhydrazil (DPPH) method, antidiabetic using α-glucosidase enzyme, and toxicity using the Bhrine Lethality Test Shrimp method (BSLT). The study showed that the methanol extract and the ethyl acetate fraction of M. malabathricum  leaves had secondary metabolites: flavonoids, tannins, and saponins. In contrast, the butanol fraction contained flavonoids and saponins, and the water fraction contained tannins. The hexane fraction of M. malabathricum leaves did not contain secondary metabolites. The result of antioxidant and antidiabetic activity tests showed that ethyl acetate fraction has higher activity with IC50 values of  23.08 µg/mL and 3.835 µg/mL. Meanwhile, the BSLT toxicity test of methanol extract and all fractions of M. malabathricum  leaves against Artemia salina L. larva had an LC50 > 1000 g/mL.
Co-Authors Indah Dwiatmi Dewijanti Mamay Maslahat Megawati Megawati