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All Journal Pharmacology and Clinical Pharmacy Research
Raghav M V
Bangalore Medical College and Research Institute
Medicine & Pharmacology

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Study to Evaluate the Efficacy and Safety of Topical Lipid-based Amphotericin B Gel 0.1% in Patients with Cutaneous Mycosis Resistant to Conventional Therapy Mamatha Kamarthi; Raghav M V; Laxminarayana Kamath; Revathi T N
Pharmacology and Clinical Pharmacy Research Vol 7, No 3 (2022)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v7i3.38892

Abstract

The last few years have seen a significant rise in the incidence of cutaneous mycosis infections resistant to conventional therapy. Topical nanostructured lipid formulations of Amphotericin B have emerged as a novel system to tackle this menace. The present study is an open-label, single-arm, prospective study to analyze the efficacy and safety of topical nanostructured lipid-based Amphotericin B gel in treating patients attending Dermatology OPD, Victoria hospital, with cutaneous mycosis resistant to conventional therapy. Thirty patients diagnosed with tinea corporis/cruris resistant to conventional therapy were included in the study.  Patients were advised to apply amphotericin B gel 0.1% on the affected area twice daily for four weeks. Outcome parameters like pruritus, erythema, vesicles, desquamation, and KOH mount were noted weekly for the assessment of efficacy and safety.  One-way ANOVA was used for statistical analysis. After treatment with Amphotericin B gel, patients showed a statistically significant reduction in pruritus, erythema, vesicles, and desquamation from baseline across time towards the end of 4 weeks (p<0.05).  Also, the Mean total score of all symptoms, which was 8.3±3.1 at baseline, was reduced to 0.9±0.7 at the end of the 4th week (p<0.05). All the patients treated were mycologically negative for KOH mount at the end of the study period. No serious adverse drug reactions were reported to treatment. To conclude, topical nanostructured lipid-based amphotericin B gel in patients with cutaneous mycosis resistant to conventional treatment was efficacious and safe.
Impact of Antidepressant Treatment on Heart Rate Variability in Patients with Depression - A Cross Sectional Study Raghav M V; Geetha A; Praveen Panchaksharimath; Nivetha Raj
Pharmacology and Clinical Pharmacy Research Vol 8, No 1 (2023)
Publisher : Universitas Padjadjaran, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/pcpr.v8i1.39623

Abstract

Heart rate variability (HRV) is a non-invasive index of cardiac autonomic regulation. HRV is reduced in depression, which indicates decreased Autonomic Nervous System flexibility. It is associated with an increase in the frequency of cardiac co-morbidities. Depression medications usually take six months for complete remission, but no data on patients on antidepressants for more than six months. Therefore, it becomes necessary to determine if anti-depressants have a better impact on HRV. The current study focused on analyzing the correction of HRV parameters after six months of antidepressant therapy. A cross-sectional study was conducted from February to September 2021 at the AFT lab inpatients. They were recruited from the Psychiatry department, Victoria Hospital, Bangalore Medical College and Research Institute, Bengaluru, Karnataka, India. The sample size was calculated to be 40 (20 Patients and 20 Healthy controls). AFT was done on all participants using Power Lab equipment and analyzed using Lab Chart 8 software. Heart rate variability parameters (AFT results) were analyzed using statistical software. The results with a p-value of >0.05% were considered statistically significant and taken up for the study. 55% of the patients with depression in our study were in the age group of 18-25 years, and the mean Ham-D (Hamilton Depression Rating Scale) score was found to be 9.8.  There is a reduction in autonomic function flexibility among patients who are on antidepressants when compared to healthy controls, even after six months of treatment. No conclusion could arrive on the class of antidepressant which was more beneficial owing to its effect on autonomic functions. Hence, randomized controlled studies comparing various classes of antidepressants to assess efficacy in reducing autonomic complications of depression should be taken up
Co-Authors Geetha A Laxminarayana Kamath Mamatha Kamarthi Nivetha Raj Praveen Panchaksharimath Revathi T N