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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Amerta Nutrition
Rivan Virlando Suryadinata
Fakultas Kedokteran, Universitas Surabaya (UBAYA), Surabaya, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Nursing Public Health Other

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EFIKASI ANTIOKSIDAN AKAR TERUNG PIPIT (Solanum torvum) TERHADAP KERUSAKAN HATI DENGAN INDUKSI CCL4 PADA Rattus norvegicus: Efikasi Antioksidan Akar Terung Pipit (Solanum torvum) terhadap Kerusakan Hati dengan Induksi CCL4 pada Rattus norvegicus Rivan Virlando Suryadinata; Dwi Martha Nur Aditya; Ryu Okiku Christina Gunawan; Mudita Lestari Utami; Bambang Wirjatmadi
Amerta Nutrition Vol. 6 No. 1SP (2022): AMERTA NUTRITION SUPPLEMENTARY EDITION Special 2nd Amerta Nutrition Conferenc
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/amnt.v6i1SP.2022.59-63

Abstract

Background: Liver disease is still a health problem in the world. In Indonesia, liver disease is dominated by liver cirrhosis. One of the causes of liver damage is an increase in the number of free radicals in the body. This will result in damage and death of liver cells and cause fibrotic tissue. A decrease in the number of liver cells will result in impaired overall liver function. Giving antioxidants can reduce free radicals that enter the body. One of the plants that contain antioxidants is the terung pipit (Solanum torvum). Objectives: This study aims to determine the antioxidant efficacy of terung pipit root (Solanum torvum) against liver damage by CCL4 induction in Rattus norvegicus. Methods: This research is experimental using a Randomized Controlled Trial (RCT) design. The research process was carried out for 11 days by dividing the experimental animals into 6 groups with 5 individuals in each group. Each treatment group will be induced with CCL4 for 5 days and followed by 7 days of administration of terung pipit root (Solanum torvum) with different doses (0.5; 1.0; 1.5 mg/grBB/day). The parameters used are the levels of SGOT-SGPT and bilirubin in the blood. Results: The results showed a decrease in the levels of SGOT-SGPT and bilirubin in the blood in the group given the terung pipit root (p≤0,05). Increasing the dose of terung pipit root administration further decreased the research parameters, although it did not reach the value of the negative control group. Conclusions: The antioxidant content in terung pipit root (Solanum torvum) can decrease in SGOT-SGPT and bilirubin levels in the blood due to liver damage in experimental animals induced by CCL4.
Hubungan Tingkat Activity Daily Living (ADL) dan Kualitas Hidup Lansia di Magetan Rinandha Yusfahreza Wildhan; Rivan Virlando Suryadinata; Ida Bagus Made Artadana
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 11, No 1 (2022): MARET 2022
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (350.195 KB) | DOI: 10.30742/jikw.v11i1.1578

Abstract

Most chronic diseases begin to appear in the elderly. Physiological decline in the elderly will also have an impact on the daily activities of the elderly. Dependence on other people is needed by most of the elderly in carrying out daily activities. This will directly affect the quality of life for the elderly. This study aims to analyze the relationship between the level of Activity Daily Living (ADL) and quality of life in the elderly group in Magetan. This research method is observational using a sample of 80 elderly people. Data were collected by purposive sampling in accordance with the inclusion and exclusion criteria in the study. The daily activity assessment process uses the Activity Daily Living (ADL) questionnaire, while the quality of life assessment also uses a questionnaire which is divided into four domains (physical, psychological, social and environmental). The research data obtained will be tested for correlation using the Spearman test. The results of the Spearman test analysis showed that there was a positive correlation between Activity Daily Living (ADL) on the four domains (physical, psychological, social and environmental) on quality of life (p<0.05). In the four domains, there was a relationship (correlation) with ADL, namely the physical domain (r=0.560), psychological domain (r=0.463), social domain (r=0.415), environmental domain (r=0.340). So it can be concluded that there is a relationship between Activity Daily Living (ADL) on the four domains, namely physical, psychological, social and environmental. However, the physical domain has the greatest influence on the daily activities of the elderly.
Co-Authors Bambang Wirjatmadi Dwi Martha Nur Aditya Ida Bagus Made Artadana Mudita Lestari Utami Rinandha Yusfahreza Wildhan Ryu Okiku Christina Gunawan