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Marthen C.P. Wongkar, Marthen C.P.
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Hubungan indeks massa tubuh dengan profil lipid pada pasien diabetes melitus tipe 2 Koampa, Pradika H.; Pandelaki, Karel; Wongkar, Marthen C.P.
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.4.1.2016.12106

Abstract

Abstract: Body Mass Index (BMI) is a measurement of nutritional status by calculating the ratio of height and weight. Type 2 Diabetes Mellitus (T2DM) is more common in a person with a BMI of more than normal. In patients with T2DM, there is lipid metabolism disorder, dyslipidaemia. Changes in lipid profiles consist of increased levels of total cholesterol, Low Density Lipoprotein (LDL), and triglycerides, and decreased levels of High Density Lipoprotein (HDL). This study aimed to obtain the correlation between body mass index and lipid profile in T2DM patients in Prof. Dr. R. D. Kandou Hospital Manado. This was a descriptive analytical study using patients’ medical record in Endocrine Clinic Prof. Dr. R. D. Kandou Hospital Manado from September to November 2015. The Pearson correlation test showed correlations between BMI and total cholesterol levels with r=0.037and p=0.763; between BMI and HDL levels with r=-0.249 and p=0.039; between BMI and LDL levels with r=0.091 and p=0,455; and between BMI and triglyceride levels with r=0.179 and p=0.142. Conclusion: Among T2DM patients, there were no significant correlations between body mass index and total cholesterol, LDL cholesterol, as wello as triglyceride levels. However, there was a significant correlation between body mass index and HDL levels. Keywords: body mass index, total cholesterol, HDL, LDL, triglycerides, T2DM Abstrak: Indeks Massa Tubuh (IMT) merupakan salah satu pengukuran status gizi dengan menghitung perbandingan tinggi badan dan berat badan. Diabetes Melitus Tipe 2 (DMT2) lebih sering terjadi pada individu dengan IMT lebih dari normal. Pada pasien DMT2 terjadi gangguan metabolisme lipid yaitu dislipidemia. Perubahan profil lipid yang terjadi yaitu peningkatan kadar Kolesterol Total, Low Density Lipoprotein (LDL), dan trigliserida, serta penurunan kadar High Density Lipoprotein (HDL). Penelitian ini bertujuan untuk mengetahui hubungan antara IMT dengan profil lipid pada pasien DMT2di RSUP Prof. Dr. R. D. Kandou Manado. Jenis penelitian ini deskriptif analitik dengan menggunakan data rekam medik pasien di Poliklinik Endokrin Bagian/SMF Ilmu Penyakit Dalam RSUP. Prof. Dr. R. D. Kandou Manado periode September – November 2015. Hasil uji korelasi Pearson memperlihatkan nilai hubungan antara IMT dan kadar kolesterol total r = 0,037 dan p = 0,763 ; nilai hubungan antara IMT dan kadar HDL r = -0,249 dan p = 0,039 ; nilai hubungan antara IMT dan kadar LDL r = 0,091 dan p = 0,455; serta nilai hubungan antara IMT dan kadar trigliserida r = 0,179 dan p = 0,142. Simpulan: Pada pasien DMT2 tidak dijumpai hubungan bermakna antara IMT dengan kadar kolesterol total, kadar LDL, dan kadar trigliserida, namun terdapat hubungan bermakna antara IMT dengan kadar HDL.Kata kunci: IMT, kolesterol total, HDL, LDL, trigliserida, DMT2
Gambaran enzim transaminase pada pasien tuberkulosis paru yang diterapi dengan obat-obat anti tuberkulosis di RSUP Prof. Dr. R. D. Kandou Manado Clarasanti, Inez; Wongkar, Marthen C.P.; Waleleng, Bradley J.
e-CliniC Vol 4, No 1 (2016): Jurnal e-CliniC (eCl)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35790/ecl.4.1.2016.12102

Abstract

Abstract: Pulmonary tuberculosis is a chronic infection and still a major worldwide health problem. Data from World Health Organization in 2013 showed that Indonesia was the fifth country with the highest prevalence of TB in the world. Treatment of TB in Indonesia is using the antituberculosis medication guide. One of the side effects of treatment is hepatotoxicity. Liver function tests commonly used are the transaminase enzymes (SGOT and SGPT). Levels of SGOT and SGPT will increase in case of damage or inflammation of the liver tissue. The results showed that after administration of the antituberculosis medication 26% of patients had high levels of transaminase enzymes meanwhile 74% of patients had normal levels of transaminase enzymes.Keywords: Pulmonal Tuberculosis, OAT, hepatotoxicity, transaminase enzymes, SGOT, SGPT Abstrak: Tuberkulosis paru adalah infeksi kronik yang sampai saat ini masih menjadi masalah kesehatan dunia yang utama. Data WHO tahun 2013 menunjukkan bahwa Indonesia menempati negara kelima dengan prevalensi TB tertinggi di dunia. Pengobatan TB di Indonesia menggunakan panduan obat antituberkuolosis (OAT) dan salah satu efek samping pengobatan ialah hepatotoksisitas. Tes fungsi hati yang umum digunakan ialah pemeriksaan enzim transaminase yakni kadar SGOT dan SGPT yang akan menunjukkan peningkatan jika terjadi kerusakan atau radang pada jaringan hati. Hasil penelitian memperlihatkan terdapat 26% pasien TB dengan kadar enzim transaminase yang tinggi setelah pemberian OAT, dan 74% pasien TB yang memiliki kadar enzim transaminase yang normal setelah pemberian OAT.Kata kunci: tuberkulosis paru, OAT, hepatotoksisitas, enzim transaminase, SGOT, SGPT