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All Journal Mandala of Health : A Scientific Journal
Vitasari Indriani
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PERBANDINGAN INDEKS ASPARTATE AMINOTRANSFERASE TO PLATELET RATIO INDEX (APRI) PADA PASIEN SIROSIS HEPATIS DAN KARSINOMA HEPATOSELULER Muhammad Rifqi Fauzan Nurkamal; Vitasari Indriani; Ika Murti Harini
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (147.935 KB) | DOI: 10.20884/1.mandala.2021.14.1.3070

Abstract

ABSTRAK Sirosis hepatis dianggap sebagai kondisi sebelum terjadinya karsinoma hepatoseluler. Sirosis hepatis dan karsinoma hepatoseluler perlu dideteksi lebih awal dengan menggunakan indeks sederhana karena prognosisnya yang buruk. APRI merupakan indeks yang dapat membantu diagnosis fibrosis dan sirosis secara signifikan. Hasil penelitian sebelumnya melaporkan adanya perbedaan signifikan pada rerata indeks APRI yang diambil dari data rekam medis pasien sirosis hepatis dan karsinoma hepatoseluler. Penelitian ini mengkaji rerata indeks APRI dari hasil pemeriksaan laboratorium pasien yang baru terdiagnosis sirosis hepatis dan karsinoma hepatoseluler. Untuk mengetahui perbandingan indeks APRI pada pasien sirosis hepatis dan karsinoma hepatoseluler. Penelitian analitik observasional dengan pendekatan cross sectional dilakukan pada 11 pasien sirosis hepatis dan 11 pasien karsinoma hepatoseluler yang baru terdiagnosis di RSUD Prof. Dr. Margono Soekarjo. Pengambilan data dilakukan dengan teknik consecutive sampling pada sampel darah pasien yang kemudian dikirim ke laboratorium Patologi Klinik. Analisis hipotesis menggunakan uji T tidak berpasangan. Rerata indeks APRI pada pasien sirosis hepatis adalah 0,79 ± 0,60. Rerata indeks APRI pada pasien karsinoma hepatoseluler adalah 7,27 ± 7,11. Terdapat perbedaan bermakna pada indeks APRI antara pasien sirosis hepatis dan karsinoma hepatoseluler dengan nilai p = 0,00 (p < 0,05). Terdapat perbedaan rerata pada indeks APRI antara pasien sirosis hepatis dan karsinoma hepatoseluler. Kata Kunci: APRI, karsinoma hepatoseluler, sirosis hepatis ABSTRACT Hepatic cirrhosis was considered as a condition before the occurrence of hepatocellular carcinoma. Hepatic cirrhosis and hepatocellular carcinoma needed to be detected earlier using a simple index because of their poor prognosis. APRI was an index that could helped diagnosing fibrosis and cirrhosis significantly. The results of previous studies reported a significant difference in the mean of APRI taken from the medical record data of hepatic cirrhosis and hepatocellular carcinoma patients. This study investigated the mean of APRI from laboratory results of newly diagnosed patients with hepatic cirrhosis and hepatocellular carcinoma. To determine the comparison of the APRI in patients with hepatic cirrhosis and hepatocellular carcinoma. An analytic observational study with cross sectional model was conducted among 11 hepatic cirrhosis and 11 hepatocellular carcinoma patients which newly diagnosed in Prof. Dr. Margono Soekarjo General Hospital. Data collection was performed by consecutive sampling method on the patient's blood sample which was then sent to the laboratory of Clinical Pathology. Hypothesis was analysed using independent t-test. The mean of APRI in hepatic cirrhosis patients is 0.79 ± 0.60. The mean of APRI in hepatocellular carcinoma patients is 7.27 ± 7.11. There is a significant difference of the APRI between the hepatic cirrhosis and hepatocellular carcinoma patients with a value of p = 0.00 (p <0.05). There is a mean difference of the APRI between the hepatic cirrhosis and hepatocellular carcinoma patients. Keywords: APRI, hepatic cirrhosis, hepatocellular carcinoma
CORRELATION OF ASPARTATE AMINOTRANSFERASE TO PLATELET RATIO INDEX (APRI) WITH THE DEGREE OF SEVERITY LIVER ORGAN IN CIRRHOSIS HEPATIC PATIENTS mahendra aulia rakhman; Vitasari Indriani; Dwi Arini E
Mandala Of Health Vol 14 No 1 (2021): Mandala Of Health
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (255.472 KB) | DOI: 10.20884/1.mandala.2021.14.1.3074

Abstract

Background: Cirrhosis hepatic is a chronic liver disease characterized by the replacement of liver tissue into scar tissue resulting in decreased liver function. The patient's diagnosis is gold standard for cirrhosis hepatic by invasive assessment cause tissue damage. The development of the way of diagnosis with secondary markers is APRI score was considered quite good in determining cirrhosis hepatic. On the other to, there is a method for assessing the severity of the liver organ in patients with cirrhosis hepatic using the Child-Pugh score. APRI scores and Child-Pugh scores are based on the calculation of secondary markers caused by hepatocyte cell fungtional damage. This is very useful in the early diagnosis of cirrhosis hepatic patients using simple markers and predicting the severity of the liver organ to assess further prognosis and management. Objective: To knowing the correlation of APRI index with the degree of severity liver organ in cirrhosis hepatic patients in RSUD Prof. dr. Margono Soekarjo. Specifically, it aims to determine the APRI score and Child-Pugh score in patients with cirrhosis hepatic. Methods: This study used a cross sectional design with a sample of 31 patients with a diagnosis of cirrhosis hepatic which was selected using a consecutive sampling technique. Primary data were obtained from a one-time blood sampling calculation and secondary data were obtained from medical records from patients with a diagnosis of liver cirrhosis from the physician in charge. Hypothesis analysis using Pearson correlation test. Resuls: Pearson test results showed a significant difference p = 0.024 (p <0.05) with the strength of the relationship r = 0.404 and the direction of a positive relationship on the correlation of APRI scores and Child-Pugh scores. Conclusions: There is a significant correlation between APRI scores with the degree of severity liver organ in cirrhosis hepatic patients in RSUD Prof. dr. Margono Soekarjo. The average APRI score in patients cirrhosis hepatic is 3, 107. The Child-Pugh score for the degree of severity liver organ is 8 or in the category of Child-Pugh B or moderate category.
Co-Authors Dwi Arini E Ika Murti Harini mahendra aulia rakhman Muhammad Rifqi Fauzan Nurkamal