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Arif Hidayat Arbie
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EFFECTS OF LOCAL ANASTESI USING LIDOCAIN OINTMENT ON WHITE RATS (RATTUS NORVEGICUS) Aprilia putri efendy; Deyke K. Baderan; Arif Hidayat Arbie
Journal of Health, Technology and Science (JHTS) Vol. 3 No. 1 (2022): Journal of Health, Technology and Science (JHTS)
Publisher : LPPM Universitas Bina Mandiri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (274.944 KB) | DOI: 10.47918/jhts.v3i1.262

Abstract

This study aims to determine the effectiveness of drug administration, namely lidocaine ointment on male and female white rats (Rattus Norvegicus) as well as to see the comparison of water samples given to experimental animals and lidocaine ointment given to experimental animals and see the effects that occur when lidocaine ointment is given to the experimental animals. experimental animal. The method used is a laboratory experimental method using 20 experimental male and female white rats which were divided into 2 groups, namely the male and female rats. cold, hot sensation of pain sensation and touch sensation in the observation period. The results showed that lidocaine ointment smeared on the left arm on white rats had a smaller number of sensation responses than any given stimulus. This shows that lidocaine ointment has the effectiveness of local anesthesia while water does not have a local anesthetic effect because the nerves in the arm are still able to respond well to the stimuli given.
COMPARATIVE ACTIVITY TESTING OF LOPERAMIDE HYDROCHLORIDUM WITH OTHER ANTIDIARE DRUG IN WHITE RATS AS AN INTRODUCTION TO DIARY Liilis Ela Pujiati; Inang Bumulo; Arif Hidayat Arbie
Journal of Health, Technology and Science (JHTS) Vol. 3 No. 4 (2022): Journal of Health, Technology and Science (JHTS)
Publisher : LPPM Universitas Bina Mandiri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (292.753 KB) | DOI: 10.47918/jhts.v3i1.264

Abstract

Diarrhea is still a health problem, especially in developing countries including Indonesia, various kinds of drugs have been used, one of which is LoperamideHydrochloridum drug with other antidiarrheal drugs. LoperamideHydrochloridum was chosen because LoperamideHydrochloridum can inhibit intestinal motility so as to prolong intestinal transit time, reduce the frequency of defecation, increase stool viscosity and prevent electrolyte loss. This study aims to determine the usefulness or differences of several anti-diarrheal drugs, and to compare the mechanism of action of each anti-diarrheal drug used. The method used is the experimental method, the experimental method is an experiment to prove a certain question or hypothesis. Experiments can be carried out in a laboratory or outside the laboratory, experimental work implies learning to do, because it can be included in the learning method. The purpose of the experimental method is that students can design, prepare, report, implement, prove and draw conclusions from various facts and information obtained when they conduct their own experiments. The results showed that in the surgical process of rat 1, the overall length of the intestine was 65 cm and the length of the marker intestine was 30 cm. Rats 2 have a total intestine length of 67 cm with a marker intestine length of 13 cm. For rat 3, the total gut length was 37 cm and the marker gut length was 11 cm. And for 4 mice, the total intestine length was 64 cm with a marker intestine length of 47 cm.
Co-Authors Aprilia putri efendy Deyke K. Baderan Inang Bumulo Liilis Ela Pujiati