<![CDATA[Abstract. Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder associated with high-fat diet consumption and characterized by hepatic inflammatory processes that contribute to disease progression. Intermittent fasting has been proposed as a non-pharmacological strategy to modulate metabolic and inflammatory responses; however, comparative evidence between dry and water intermittent fasting on hepatic inflammation remains limited. This study aimed to compare the effects of dry intermittent fasting and water intermittent fasting on hepatic inflammation scores in mice fed a high-fat diet. This quantitative experimental study employed a post-test only controlled group design using 28 paraffin-embedded liver tissue blocks from male Swiss Webster mice. Intermittent fasting was conducted for 30 days with a daily fasting duration of 14 hours. Hepatic inflammation was assessed histopathologically using hematoxylin–eosin staining based on the number of inflammatory foci per field of view. Data analysis was performed using the Chi-square test and subsequently Fisher’s Exact Test due to unmet assumptions, followed by Spearman correlation analysis. The results showed no statistically significant difference in hepatic inflammation scores between the dry intermittent fasting and water intermittent fasting groups (Fisher’s Exact Test, p = 1.00). Spearman correlation analysis also demonstrated no significant association between the type of intermittent fasting and hepatic inflammation score (r = 0.001; p > 0.05). Abstrak. Non-alcoholic fatty liver disease (NAFLD) merupakan gangguan metabolik yang berkaitan dengan konsumsi pakan tinggi lemak dan ditandai oleh proses inflamasi hepar yang berperan dalam progresivitas penyakit. Puasa intermiten dikenal sebagai pendekatan nonfarmakologis yang berpotensi memodulasi respon metabolik dan inflamasi, namun perbandingan efek puasa intermiten kering dan air terhadap inflamasi hepar masih terbatas. Penelitian ini bertujuan membandingkan efek puasa intermiten kering dan puasa intermiten air terhadap skor inflamasi hepar pada mencit yang diberi pakan tinggi lemak. Penelitian ini merupakan studi eksperimental kuantitatif dengan desain post-test only controlled group menggunakan 28 blok parafin jaringan hepar mencit jantan galur Swiss Webster. Puasa intermiten dilakukan selama 30 hari dengan durasi puasa 14 jam per hari. Inflamasi hepar dinilai secara histopatologis menggunakan pewarnaan hematoksilin–eosin berdasarkan jumlah fokus inflamasi per lapang pandang. Analisis data dilakukan menggunakan uji Chi-square dan dilanjutkan dengan Fisher’s Exact Test, serta analisis korelasi Spearman. Hasil penelitian menunjukkan tidak terdapat perbedaan bermakna pada skor inflamasi hepar antara kelompok puasa intermiten kering dan air (Fisher’s Exact Test, p = 1,00). Analisis Spearman juga menunjukkan tidak terdapat hubungan bermakna antara jenis puasa intermiten dan skor inflamasi hepar (r = 0,001; p > 0,05).]]>
