Menstrual pain, known as dysmenorrhea, is a common health problem experienced by adolescent girls and may interfere with their daily activities, academic performance, and quality of life. Adequate knowledge is considered an important factor in promoting appropriate menstrual pain management. However, knowledge does not always translate into appropriate health behaviors. This study aimed to determine the relationship between knowledge and behavior in managing menstrual pain among adolescent girls. A quantitative study with a cross-sectional design was conducted involving 55 female students. Data were collected using structured questionnaires assessing respondents' knowledge and behaviors related to menstrual pain management. The collected data were analyzed using univariate and bivariate analyses, with the chi-square test applied to examine the relationship between the variables. The results showed a p-value of 0.232, which was greater than the significance level of 0.05. This finding indicates that there was no statistically significant relationship between knowledge and behavior in managing menstrual pain among the respondents. These results suggest that adequate knowledge alone may not be sufficient to encourage appropriate menstrual pain management practices among adolescents. Therefore, healthcare providers and educational institutions should implement comprehensive health education programs that not only improve knowledge but also address attitudes, personal experiences, family support, environmental influences, access to healthcare services, and individual health habits. Such an approach may help adolescents develop more appropriate and effective menstrual pain management behaviors.