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All Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan
Dimas Thoriq Muhammad Iqbal
Master Programe Pharmacology Molecular, Faculty of Pharmacy, Universitas Indonesia
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Metabolic Syndrome Induced by Hipercalory Diet in Wistar Rats: impact on diabetic risk, dyslipidemia and hypertension complication Dimas Thoriq Muhammad Iqbal; Fadlina Chany Saputri; Abdul Mun’im; Vicko Suswidiantoro
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 8, No S1: Supplement
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (717.978 KB) | DOI: 10.30604/jika.v8iS1.1692

Abstract

Objective: Metabolic syndrome is a group of metabolic disorders that are usually found in individuals with a high risk of type 2 diabetes mellitus (T2DM) and cardiovascular disease. Comparison of diet composition, especially macronutrients, over a certainperiode in both humans and experimental animals can allegedly increase the risk of metabolic syndrome. This study aims to determine the use of a hypercaloric diet that can cause metabolic syndrome in male Wistar rats. Methods: The hypercaloric diet was administered orally in pellets and oral solution to rats for 16 weeks. Analysis of the condition of the metabolic syndrome was carried out by looking at the increase in serum levels of total cholesterol, triglycerides and decreased HDL levels. Fasting blood sugar and fasting insulin levels were also seen to increase and blood pressure testing was carried out to see an increase in blood pressure after 16 weeks of giving a hypercaloric diet. Results: Administration of a hypercaloric diet showed an increased risk of metabolic syndrome in rats. Administration for 16 weeks showed a significant difference in the improvementofs conditions of dyslipidemia, insulin resistance and hypertension. Conclusion: Based on the results, a hypercaloric diet for 16 weeks can cause metabolic syndrome in rats. Abstrak: Objektif: Sindrom metabolik adalah sekelompok kelainan metabolik yang biasanya ditemukan pada individu dengan risiko tinggi diabetes militus tipe 2 (T2DM) dan penyakit kardiovaskular. Perbandingan komposisi diet khususnya makronutrien, dalam jangka waktu tertentu baik pada manusia maupun hewan coba disinyalir dapat meningkatkan resiko dari sindroma metabolik. Penelitian ini bertujuan untuk menentukan penggunaan diet hipercalori yang dapat menyebabkan kondisi sindrome metabolikpada tikus Wistar jantan. Metode:diet hiperkalori diberikan secara oral dalam bentuk pelet dan larutan oral pada tikus selama 16 minggu. Analisis terhadap kondisi syndrome metabolic dilakukan dengan melihat peningkatan kadar serum kolesterol total, trigliserida dan penurunan kadar HDL. Kadar gula darah puasa dan insulin puasa juga dilihat peningkatannya serta dilakukan pengujian tekanan darah untuk melihat terjadinya peningkatan tekanan darah setelah 16 minggu pemberian diet hiperkalori. Hasil: Pemberian diet hiperkalori menunjukkan adanya peningkatan risiko sindrom metabolic pada tikus. Pemberian selama 16 minggu menujukkan adanya perbedaan signifikan pada peningkatan kearah kondisi dyslipidemia, resistensi insulin dan hipertensi. Kesimpulan: Berdasarkan hasil, pemberian diet hiperkalori  selama 16 minggu dapat menyebabkan terjadinya kondisi sindrom metabolic pada tikus
Cognitive Behavioral Therapy for Diabetic Patients Dimas Thoriq Muhammad Iqbal; Fadlina Chany Saputri; Abdul Mun’im; Vicko Suswidiantoro
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 7, No 1: March, 2022
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (753.302 KB) | DOI: 10.30604/jika.v7i1.825

Abstract

Improving self-care in T2DM patients is critical so that patients can achieve targeted blood glucose levels to prevent complications and independently perform daily tasks to improve their quality of life and life satisfaction. Psychological intervention is believed to be able to change a person's behavior towards a better direction in disease control and prevention. This study measures the impact of Cognitive-Behavioural Therapy (CBT) interventions on the self-care management of T2DM patients. This quasi-experimental study used a pretest-posttest with a control group design. The research subjects were divided into two groups, namely the intervention group (35 people) and the control group (35 people). The study was conducted at the Tello Primary Health Center in April 2021. The data were analyzed using the t-dependent test (?=0.05). The results of the study showed that in the intervention group, there were differences in the self-care management of T2DM patients before and after being given CBT, which included eating patterns (p less than 0.001; 95%CI -6.663-(-4.796)), physical activity (p less than 0.001; 95% CI -5.344-(-4.370)), and attitude (p= less than 0.001; 95%CI -13.086-(-10.114)). In the control group, there was no difference in the self-care management of T2DM patients, which included eating patterns (p= 0.083; 95%CI -0.183-0.012), physical activity (p= 0.058; 95%CI -0.291-0.005), and T2DM patients attitudes (p= 0.094; 95%CI -0.225-0.003). This means that CBT effectively improves the self-care management of T2DM patients.Abstrak: Peningkatan perawatan diri pada pasien DM tipe 2 sangat penting dilakukan agar pasien dapat mencapai kadar glukosa darah yang ditargetkan untuk mencegah komplikasi dan secara mandiri melakukan tugas sehari-hari sehingga meningkatkan kualitas hidup dan kepuasan hidup mereka. Intervensi psikologis dipercaya mampu mengubah perilaku seseorang ke arah yang lebih baik dalam pengendalian dan pencegahan penyakit. Studi ini bertujuan mengukur dampak intervensi Cognitive–behavioural therapy (CBT) terhadap manajemen perawatan diri pasien DM tipe 2. Quasi-experimental study ini menggunakan desain pretest-posttest with control group design. Subjek penelitian dibagi ke dalam dua kelompok yaitu kelompok intervensi (35 orang) dan kelompok kontrol (35 orang). Penelitian dilakukan di Puskesmas Tello pada bulan April tahun 2021. Data dianalisis menggunakan uji t-dependent (p=0,05). Hasil studi menunjukkan bahwa pada kelompok intervensi terdapat perbedaan manajemen perawatan diri pasien DM tipe 2 sebelum dan sesudah diberikan CBT yang meliputi pola makan (p kurang dari 0,001; 95%CI -6,663-(-4,796)), aktivitas fisik (p kurang dari 0,001;95%CI -5,344-(-4,370)), dan sikap (p kurang dari 0,001; 95%CI -13,086-(-10,114)). Sedangkan pada kelompok kontrol, tidak terdapat perbedaan manajemen perawatan diri pasien DM tipe 2 yang meliputi pola makan (p= 0,083; 95%CI -0,183-0,012), aktivitas fisik (p= 0,058;95%CI -0,291-0,005), dan sikap pasien DM (p= 0,094; 95%CI -0,225-0,003). Artinya CBT efektif dalam meningkatkan manajemen perawatan diri pasien DM tipe 2.
Co-Authors Abdul Mun’im Fadlina Chany Saputri Suswidiantoro, Vicko