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All Journal Bioscientist : Jurnal Ilmiah Biologi Indonesian Journal of Biology Education
Gravinda Widyaswara
STIKes Guna Bangsa Yogyakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Social Sciences

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Screening Parameters of Transfusion-Transmitted Infection using Rapid Diagnostic Method Gravinda Widyaswara; Aulia Rahman; Prilly Layyinatunnisa; Maria Regina Sepe; Rosadelima Dagaina Koten; Zakia Tanzila; Syofianis; Delia Irjayanti Tamu Apu
Indonesian Journal of Biology Education Vol. 7 No. 1 (2024): INDONESIAN JOURNAL OF BIOLOGY EDUCATION
Publisher : Universitas Tidar

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Abstract

Blood transfusions are an important part of medicine for patient recovery. Therefore, the transfused blood must be free from viruses, bacteria, and even parasites that can be transmitted through blood transfusions. Human Immunodeficiency Virus (HIV/AIDS), Hepatitis C, Hepatitis B, and Syphilis are among the illnesses that can be transferred through blood transfusions. This research aims to determine screening parameters for transfusion-transmitted infection using the rapid diagnostic test method. This type of research is experimental with a cross-sectional design. The samples used were ten blood samples, taken intravenously and then centrifuged at a speed of 1300 rpm for 4 minutes. After that, screening is carried out with a rapid diagnostic test. The screening results of the ten blood samples examined were valid and negative or non-reactive for HIV/AIDS, Hepatitis C, Hepatitis B, and Syphilis. These results indicate that the blood samples tested can be categorized as blood samples that passed the screening test or the blood examination test for four parameters of transfusion-transmitted infection.
Molecular Docking Analysis of Soft Coral (Rhytisma sp.) Derived Compounds as EGFR Inhibitors in Non-Small Cell Lung Cancer (NSCLC) Rozikin; Tri Wahyu Setyaningrum; Widie Kemala Hapsari; Ozie Akbar Pratama; Gravinda Widyaswara; Mursal Ghazali; Novita Tri Artiningrum
Bioscientist : Jurnal Ilmiah Biologi Vol. 14 No. 1 (2026): March
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v14i1.19509

Abstract

The epidermal growth factor receptor (EGFR) is a crucial target in the treatment of non-small cell lung cancer (NSCLC) due to its significant role in tumor cell proliferation and survival. This study investigates the potential of marine-derived compounds from soft coral (Rhytisma sp.) as EGFR inhibitors through molecular docking and pharmacokinetic predictions. Eight compounds identified via GC-MS were docked against the EGFR tyrosine kinase domain (PDB ID: 2ITY) using AutoDock Vina, with Gefitinib serving as the reference drug. The top-performing compounds exhibited binding affinities ranging from –7.0 to –7.4 kcal/mol, closely aligning with Gefitinib's affinity of –7.6 kcal/mol. Notably, 4,12,12-trimethyl-9-methylidene-5-oxatricyclo[8.2.0.0⁴,⁶]dodecane demonstrated the strongest interactions, involving critical residues such as MET793 and LYS745. Pharmacokinetic profiling conducted with SwissADME and pkCSM confirmed favorable drug-likeness and high absorption potential. Toxicity analysis using ProTox-3.0 indicated low toxicity (Class IV) and no predicted hepatotoxicity, carcinogenicity, or mutagenicity. These findings suggest that phytocompounds derived from Rhytisma sp., particularly terpenoid-based structures, present a promising scaffold for the development of EGFR-targeted anticancer drugs.
Co-Authors Aulia Rahman Delia Irjayanti Tamu Apu Maria Regina Sepe Mursal Ghazali Novita Tri Artiningrum Ozie Akbar Pratama Prilly Layyinatunnisa Rosadelima Dagaina Koten Rozikin Syofianis Tri Wahyu Setyaningrum Widie Kemala Hapsari Zakia Tanzila