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POTENSI ANTIINFLAMASI JUS BUAH MANGGIS (Garcinia mangostana) TERHADAP DENATURASI PROTEIN IN VITRO Aditya, Muhammad Rizky Tri; Marisa, Donna; Suhartono, Eko
Berkala Kedokteran Vol 11, No 2 (2015): September 2015
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v11i2.138

Abstract

Protein denaturation is a cause of inflammation. Autoantigens produced in diseases linked with inflammation are thought to be caused by protein denaturation. Mangosteen fruit (Garcinia mangostana) is used widely in Southeast Asia as an alternativemedicine because of its strong antioxidant property, thus it potentially has an antiinflammatory effect. The aim of this study is to test the anti inflammatory potency of mangosteen juice. This is a quasi experimental study with non randomized posttest-only with control group design method, using reaction model of inflammation consisted of two groups: mangosteen juice as the test group and natrium diclofenac as the standard group, divided into 10%, 20%, and 30% concentration. IC50 value is used to determine the anti-inflammatory potency of mangosteen juice as protein denaturation inhibitor. The result of this study indicate that the mangosteen fruit juice has the IC50 value of 16,91% (r = 0,965), whereas for diclofenac sodium by 11,87% (r = 0,866). A positive value of r indicates a positive relation between concentration and anti inflammatory potency. The result shows that mangosteen juice has a potential as a protein denaturation inhibitor.Keywords: protein denaturation, antiinflammation, mangosteen.
HUBUNGAN STATUS GIZI DENGAN LAMA HARI RAWAT INAP PASIEN ANAK DIARE AKUT Amin, Muhammad Rizal; Hartoyo, Edi; Marisa, Donna
Berkala Kedokteran Vol 12, No 2 (2016)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v12i2.1862

Abstract

Abstract: Good nutritional status can reduce the risk of diarrhea, while children with less or poor nutritional status enables more frequent and more susceptible to diarrhea. The worse the nutrition of a children, the frequency of diarrhea increases. This situation may have a relationship with length of stay. Length of stay of childhood diarrhea is influenced by the childs physical condition (good nutritional status, less, or worse). The purpose of this study is analyzing the relationship between nutritional status and length of stay of pediatric patient on acute diarrhea in Ulin General Hospital Banjarmasin 2014. This study was done by observational analytic with cross sectional approach. Total of 50 samples were obtained by purposive sampling; 2 patients with excess nutritional status, 37 patients with good nutritional status, 8 patients with less nutritional status, and 3 patients with poor nutritional status. Data was analyzed using the Kruskal-Wallis test with a confidence level of 95%  showed that the average length of stay in each nutritional status have no significant value difference (p=0,193). It was concluded that there is no relationship between nutritional status and length of stay of pediatric patient on acute diarrhea in Ulin General Hospital Banjarmasin 2014. Keywords: nutritional status, length of stay, acute diarrhea Abstrak: Status gizi anak yang baik dapat mengurangi risiko terkena penyakit diare, sedangkan anak dengan status gizi kurang atau buruk memungkinkan lebih sering dan lebih mudah terkena diare. Makin buruk gizi seorang anak, ternyata frekuensi diare semakin banyak. Keadaan ini mungkin memiliki hubungan dengan lama hari rawat inap. Hari rawat diare anak salah satunya dipengaruhi oleh kondisi fisik anak (status gizi baik, kurang, atau buruk). Tujuan penelitian ini adalah untuk menganalisis hubungan antara status gizi dengan lama hari rawat inap pasien anak diare akut di RSUD Ulin Banjarmasin tahun 2014. Penelitian ini bersifat observasional analitik dengan pendekatan cross sectional. Sebanyak 50 sampel didapat secara purposive  sampling sesuai kriteria inklusi, 2 pasien  status gizi lebih, 37 pasien status gizi baik, 8 pasien status gizi kurang, dan 3 pasien status gizi buruk. Analisis data menggunakan uji Kruskal Wallis dengan tingkat kepercayaan 95% menunjukkan bahwa rerata lama hari rawat inap di setiap status gizi tidak memiliki perbedaan nilai yang bermakna (p=0,193). Hal ini berarti bahwa tidak terdapat hubungan antara status gizi dengan lama hari rawat inap pasien anak diare akut di RSUD Ulin Banjarmasin Tahun 2014. Kata-kata kunci: status gizi, lama hari rawat inap, diare akut